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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Classic and Novel SHBG effects on the Cardiovascular System in Men
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<blockquote data-quote="madman" data-source="post: 205963" data-attributes="member: 13851"><p><em><strong>*Circulating SHBG modulates the level of free sex-steroid hormones that can enter diverse target cells [22]. The endocrinological concept is known as the “free hormone hypothesis” states that the “bioavailable” steroid hormone, i.e., the one that has an effect when bound to its receptor, is the unbound or “free” fraction of steroid hormones [23]. </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*However, recent evidence indicates that circulating SHBG not only is a passive carrier of male sex hormones but also actively regulates testosterone uptake and androgen signaling [24]. Because circulating SHBG binds to sex hormones, the relative plasma levels of this protein can modulate the concentrations of sex-related hormones accessible for use by the body, which has an impact on the processes regulated by the sex hormones [25]. SHBG can also release hormones in specific tissues and cells directly, which can influence both production and effects of sex hormones as well as the expression and function of circulating SHBG. Also, sex hormones bound to circulating SHBG can change the affinity of SHBG to its peripheral receptors. Moreover, intracellular expression of SHBG in testicular proximal tubule cells increases the uptake of dihydrotestosterone and prolongs the expression of androgen-responsive genes [26].</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 205963, member: 13851"] [I][B]*Circulating SHBG modulates the level of free sex-steroid hormones that can enter diverse target cells [22]. The endocrinological concept is known as the “free hormone hypothesis” states that the “bioavailable” steroid hormone, i.e., the one that has an effect when bound to its receptor, is the unbound or “free” fraction of steroid hormones [23]. *However, recent evidence indicates that circulating SHBG not only is a passive carrier of male sex hormones but also actively regulates testosterone uptake and androgen signaling [24]. Because circulating SHBG binds to sex hormones, the relative plasma levels of this protein can modulate the concentrations of sex-related hormones accessible for use by the body, which has an impact on the processes regulated by the sex hormones [25]. SHBG can also release hormones in specific tissues and cells directly, which can influence both production and effects of sex hormones as well as the expression and function of circulating SHBG. Also, sex hormones bound to circulating SHBG can change the affinity of SHBG to its peripheral receptors. Moreover, intracellular expression of SHBG in testicular proximal tubule cells increases the uptake of dihydrotestosterone and prolongs the expression of androgen-responsive genes [26].[/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Classic and Novel SHBG effects on the Cardiovascular System in Men
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