ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Classic and Novel SHBG effects on the Cardiovascular System in Men
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 205960" data-attributes="member: 13851"><p><strong>Figure 1: <u>Signaling pathways activated by SHBG</u>. The figure illustrates the action mechanism of SHBG as a hormone carrier and SHBG direct actions. (1) Free circulating androgens and estrogens that correspond to the bioavailable portion of sex hormones can cross the plasma membrane and bind intracellular sex hormone receptors, thus activating the “classic,” genomic sex hormone intracellular pathways. (2) As described in the literature, free circulating sex hormones can also bind to putative membrane receptors activating “fast, nongenomic intracellular signaling pathways.” (3) Another putative membrane receptor, for SHBG, can also activate intracellular signaling pathways, leading to fast, nongenomic effects. (4) (e megalin receptor, which induces the internalization of SHBG and a retrograde pathway that affects nuclear and mitochondrial function, can also account for some SHBG-induced intracellular effects.</strong></p><p><strong>[ATTACH=full]15860[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 205960, member: 13851"] [B]Figure 1: [U]Signaling pathways activated by SHBG[/U]. The figure illustrates the action mechanism of SHBG as a hormone carrier and SHBG direct actions. (1) Free circulating androgens and estrogens that correspond to the bioavailable portion of sex hormones can cross the plasma membrane and bind intracellular sex hormone receptors, thus activating the “classic,” genomic sex hormone intracellular pathways. (2) As described in the literature, free circulating sex hormones can also bind to putative membrane receptors activating “fast, nongenomic intracellular signaling pathways.” (3) Another putative membrane receptor, for SHBG, can also activate intracellular signaling pathways, leading to fast, nongenomic effects. (4) (e megalin receptor, which induces the internalization of SHBG and a retrograde pathway that affects nuclear and mitochondrial function, can also account for some SHBG-induced intracellular effects. [ATTACH type="full"]15860[/ATTACH][/B] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Classic and Novel SHBG effects on the Cardiovascular System in Men
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top