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General Health & Fitness
Nutrition and Supplements
Citrulline the new star for increasing nitric oxide
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<blockquote data-quote="DorianGray" data-source="post: 194271" data-attributes="member: 40477"><p>The dietary application of L-arginine is the basic determinant of the L-arginine level in plasma, as the biosynthesis of L-arginine is not able to balance inadequate intake or deficiency. Providing supplementation of substrate to individuals with inadequate NO, therefore, has been suggested as a rational approach to NO production by the NO synthase, provided the enzyme is functional an the protein complex (as mentioned above-ASL, partial urea cycle). The problem is the protein pathway integrity is suspect in those that exhibit NO or endothelial compromise. Perhaps lump festering cardiovascular problems and ED sufferers in this group. So, it makes one wonder to what extent Citrulline would be processed in the shunt to make even exogenous supplementation effective. The protein complex, ASA, ASL,and NOS reveals that cells use intracellular pools of L-citrulline, which is then converted to L-arginine, rather than utilizing extracellular L-arginine to make NO. On a more critical note, research has shown L-arginine supplementation had demonstrated increase mortality in post-myocardial infarction patients and worsening of conditions in those with peripheral artery disease (PAD). Boger RH. L-arginine therapy in cardiovascular pathologies...Curr Opin Clin Nutr Metab Care. 2008;11 (1):55-61, Erez A, et al, Requirementof arginosuccinate lyase for systemic nitric oxide production. Nat Med. 2011;17(12):1619-26.</p></blockquote><p></p>
[QUOTE="DorianGray, post: 194271, member: 40477"] The dietary application of L-arginine is the basic determinant of the L-arginine level in plasma, as the biosynthesis of L-arginine is not able to balance inadequate intake or deficiency. Providing supplementation of substrate to individuals with inadequate NO, therefore, has been suggested as a rational approach to NO production by the NO synthase, provided the enzyme is functional an the protein complex (as mentioned above-ASL, partial urea cycle). The problem is the protein pathway integrity is suspect in those that exhibit NO or endothelial compromise. Perhaps lump festering cardiovascular problems and ED sufferers in this group. So, it makes one wonder to what extent Citrulline would be processed in the shunt to make even exogenous supplementation effective. The protein complex, ASA, ASL,and NOS reveals that cells use intracellular pools of L-citrulline, which is then converted to L-arginine, rather than utilizing extracellular L-arginine to make NO. On a more critical note, research has shown L-arginine supplementation had demonstrated increase mortality in post-myocardial infarction patients and worsening of conditions in those with peripheral artery disease (PAD). Boger RH. L-arginine therapy in cardiovascular pathologies...Curr Opin Clin Nutr Metab Care. 2008;11 (1):55-61, Erez A, et al, Requirementof arginosuccinate lyase for systemic nitric oxide production. Nat Med. 2011;17(12):1619-26. [/QUOTE]
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Citrulline the new star for increasing nitric oxide
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