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Citrulline the new star for increasing nitric oxide
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<blockquote data-quote="madman" data-source="post: 189621" data-attributes="member: 13851"><p><strong>FIGURE <span style="color: rgb(44, 130, 201)">1 A,</span> <span style="color: rgb(184, 49, 47)">Determinants of Arg plasma flux and Arg catabolic pathways.</span> Both exogenous (10-30%) and endogenous sources (60-90%) contribute to Arg plasma flux. A large fraction of Arg flux is diverted into arginase I and urea cycle <span style="color: rgb(184, 49, 47)">(50% by hepatic and 15% by extrahepatic arginase I)</span>; 10-30% of Arg fraction is utilized for the synthesis of creatine <span style="color: rgb(184, 49, 47)">(using l-arginine: glycine amidinotransferase; AGAT)</span>, and only a minor fraction is shuttled into NO production.<span style="color: rgb(44, 130, 201)"> B,</span> Cit flux is supported mainly by the endogenous sources. The intestinal biosynthesis of Cit provides 60-90% of Cit flux and is mainly supported by the conversion of glutamine to Cit. Extraintestinal synthesis accounting for 10-30% of Cit flux, is mainly relayed on both the Cit-NO cycle and the ADMA-DDAH pathway. Cit flux is entirely used for Arg production via both renal and non-renal ASS-ASL pathways. <span style="color: rgb(26, 188, 156)">ADMA,</span> asymmetric dimethylarginine; <span style="color: rgb(26, 188, 156)">DDAH,</span> dimethylarginine dimethylaminohydrolase; <span style="color: rgb(26, 188, 156)">ASS,</span> argininosuccinate synthetase;<span style="color: rgb(26, 188, 156)"> ASL,</span> argininosuccinate lyase. <span style="color: rgb(26, 188, 156)">Arg, </span>Arginine; <span style="color: rgb(26, 188, 156)">Cit,</span> Citrulline, <span style="color: rgb(26, 188, 156)">Gln,</span> glutamine, <span style="color: rgb(26, 188, 156)">Pro,</span> proline </strong></p><p>[ATTACH=full]11301[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 189621, member: 13851"] [B]FIGURE [COLOR=rgb(44, 130, 201)]1 A,[/COLOR] [COLOR=rgb(184, 49, 47)]Determinants of Arg plasma flux and Arg catabolic pathways.[/COLOR] Both exogenous (10-30%) and endogenous sources (60-90%) contribute to Arg plasma flux. A large fraction of Arg flux is diverted into arginase I and urea cycle [COLOR=rgb(184, 49, 47)](50% by hepatic and 15% by extrahepatic arginase I)[/COLOR]; 10-30% of Arg fraction is utilized for the synthesis of creatine [COLOR=rgb(184, 49, 47)](using l-arginine: glycine amidinotransferase; AGAT)[/COLOR], and only a minor fraction is shuttled into NO production.[COLOR=rgb(44, 130, 201)] B,[/COLOR] Cit flux is supported mainly by the endogenous sources. The intestinal biosynthesis of Cit provides 60-90% of Cit flux and is mainly supported by the conversion of glutamine to Cit. Extraintestinal synthesis accounting for 10-30% of Cit flux, is mainly relayed on both the Cit-NO cycle and the ADMA-DDAH pathway. Cit flux is entirely used for Arg production via both renal and non-renal ASS-ASL pathways. [COLOR=rgb(26, 188, 156)]ADMA,[/COLOR] asymmetric dimethylarginine; [COLOR=rgb(26, 188, 156)]DDAH,[/COLOR] dimethylarginine dimethylaminohydrolase; [COLOR=rgb(26, 188, 156)]ASS,[/COLOR] argininosuccinate synthetase;[COLOR=rgb(26, 188, 156)] ASL,[/COLOR] argininosuccinate lyase. [COLOR=rgb(26, 188, 156)]Arg, [/COLOR]Arginine; [COLOR=rgb(26, 188, 156)]Cit,[/COLOR] Citrulline, [COLOR=rgb(26, 188, 156)]Gln,[/COLOR] glutamine, [COLOR=rgb(26, 188, 156)]Pro,[/COLOR] proline [/B] [ATTACH type="full"]11301[/ATTACH] [/QUOTE]
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Citrulline the new star for increasing nitric oxide
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