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Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
Cialis versus Flomax in Men with Prostate Enlargement
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<blockquote data-quote="Nelson Vergel" data-source="post: 8442" data-attributes="member: 3"><p><strong>Treatment satisfaction with tadalafil or tamsulosin versus placebo in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: Results from a randomized, placebo-controlled study - Abstract</strong></p><p></p><p><strong>OBJECTIVES:</strong> To assess treatment satisfaction with tadalafil or tamsulosin versus placebo in a 12-week, randomized, double-blind study of men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH).</p><p></p><p><strong>PATIENTS AND METHODS:</strong> Following a 4-week placebo lead-in period, men aged over 45 years with IPSS 13 received placebo (N=172), tadalafil 5-mg (N=171), or tamsulosin 0.4-mg (N=168) once daily for 12 weeks. Treatment Satisfaction Scale-BPH (TSS-BPH) responses were assessed based on median treatment differences using the van Elteren test.</p><p></p><p><strong>RESULTS:</strong> Overall treatment satisfaction was greater for tadalafil versus placebo (p=0.005), based on greater satisfaction with efficacy (p=0.003); neither overall treatment satisfaction nor satisfaction with efficacy was greater for tamsulosin versus placebo (p&#8805;0.409). For individual questions, 66.5% of men rated tadalafil treatment as effective/very effective (Q1; versus placebo, p=0.011), 72.6% would definitely/probably recommend their treatment (Q3; p=0.043), 71.8% were generally very satisfied/satisfied with their medication (Q8; p< 0.003), and 65.0% would definitely/probably continue therapy (Q10; p=0.035). With tamsulosin, differences versus placebo were not statistically significant. Subgroup analyses of overall TSS-BPH by baseline age (65/>65), history of erectile dysfunction (yes/no), LUTS/BPH severity (IPSS < 20), total testosterone level (< 300 ng/dL), and age-specific predicted prostate volume (< 40 mL) showed no statistically significant treatment-subgroup interactions. Men with recent prior alpha-blocker therapy demonstrated greater treatment satisfaction with tadalafil versus placebo, with only borderline difference for men without prior therapy.</p><p></p><p><strong>CONCLUSION:</strong> <strong>Treatment satisfaction was greater with tadalafil versus placebo, with no significant difference between tamsulosin and placebo.</strong></p><p></p><p><strong>Written by:</strong></p><p>Oelke M, Giuliano F, Baygani SK, Melby T, Sontag A.</p><p><em>Department of Urology, Hannover Medical School, Hannover, Germany.</em></p><p><strong>Reference:</strong> BJU Int. 2014 Mar 10. Epub ahead of print.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 8442, member: 3"] [B]Treatment satisfaction with tadalafil or tamsulosin versus placebo in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: Results from a randomized, placebo-controlled study - Abstract[/B] [B]OBJECTIVES:[/B] To assess treatment satisfaction with tadalafil or tamsulosin versus placebo in a 12-week, randomized, double-blind study of men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH). [B]PATIENTS AND METHODS:[/B] Following a 4-week placebo lead-in period, men aged over 45 years with IPSS 13 received placebo (N=172), tadalafil 5-mg (N=171), or tamsulosin 0.4-mg (N=168) once daily for 12 weeks. Treatment Satisfaction Scale-BPH (TSS-BPH) responses were assessed based on median treatment differences using the van Elteren test. [B]RESULTS:[/B] Overall treatment satisfaction was greater for tadalafil versus placebo (p=0.005), based on greater satisfaction with efficacy (p=0.003); neither overall treatment satisfaction nor satisfaction with efficacy was greater for tamsulosin versus placebo (p≥0.409). For individual questions, 66.5% of men rated tadalafil treatment as effective/very effective (Q1; versus placebo, p=0.011), 72.6% would definitely/probably recommend their treatment (Q3; p=0.043), 71.8% were generally very satisfied/satisfied with their medication (Q8; p< 0.003), and 65.0% would definitely/probably continue therapy (Q10; p=0.035). With tamsulosin, differences versus placebo were not statistically significant. Subgroup analyses of overall TSS-BPH by baseline age (65/>65), history of erectile dysfunction (yes/no), LUTS/BPH severity (IPSS < 20), total testosterone level (< 300 ng/dL), and age-specific predicted prostate volume (< 40 mL) showed no statistically significant treatment-subgroup interactions. Men with recent prior alpha-blocker therapy demonstrated greater treatment satisfaction with tadalafil versus placebo, with only borderline difference for men without prior therapy. [B]CONCLUSION:[/B] [B]Treatment satisfaction was greater with tadalafil versus placebo, with no significant difference between tamsulosin and placebo.[/B] [B]Written by:[/B] Oelke M, Giuliano F, Baygani SK, Melby T, Sontag A. [I]Department of Urology, Hannover Medical School, Hannover, Germany.[/I] [B]Reference:[/B] BJU Int. 2014 Mar 10. Epub ahead of print. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
Cialis versus Flomax in Men with Prostate Enlargement
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