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Cialis (Tadalafil) steady-state literature
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<blockquote data-quote="Excel Male" data-source="post: 272972" data-attributes="member: 1"><p>This paper is from 2010, but I'd like to draw attention to it as steady-state has been emphasized in threads about HRT.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939761/" target="_blank"><strong>Reference</strong></a></p><p>[h2]<strong>Here are some things covered in this study:</strong>[/h2]</p><p>[ul]</p><p> [li]Steady state of tadalafil is reached after 5 days. This is probably why the Cialis website notes 4-5 days as being when you should see daily low dosages take effect.[/li]</p><p> [li]Steady-state tadalafil plasma concentration is 1.6 times higher than that of a single dose.[/li]</p><p> [li]Tadalafil 5mg once a day leads to a steady-state trough of 55 ng/mL, which corresponds to 90% PDE5 inhibition [style=font-style: italic;]in vitro[/style], which is the therapy standard likely to produce erections in most men.[/li]</p><p> [li]It is recommended to not consume grapefruit, especially when on a daily dose protocol. It slows the excretion of tadalafil. The study suggests either on-demand exclusively and avoiding grapefruit before taking it, or the lowest possible daily dose(2.5mg once daily).[/li]</p><p>[/ul]</p><p>Based on what I know about grapefruit kinetics in the liver, liver processing of some <strong><a href="https://www.excelmale.com/how-to-increase-testosterone-naturally-2/" target="_blank">pharmaceuticals</a></strong> will be slowed for 24 hours. If you use tadalafil on-demand and you have grapefruit or juice, wait at least 24 hours before taking a dose.</p><p></p><p>Also, others on the forum have also suggested splitting the dosage of tadalafil and taking once every 12 hours. Compared to a single daily dose, this would raise the trough level, but lower the peak for a more regular plasma concentration.</p></blockquote><p></p>
[QUOTE="Excel Male, post: 272972, member: 1"] This paper is from 2010, but I'd like to draw attention to it as steady-state has been emphasized in threads about HRT. [url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939761/][b]Reference[/b][/url] [h2][b]Here are some things covered in this study:[/b][/h2] [ul] [li]Steady state of tadalafil is reached after 5 days. This is probably why the Cialis website notes 4-5 days as being when you should see daily low dosages take effect.[/li] [li]Steady-state tadalafil plasma concentration is 1.6 times higher than that of a single dose.[/li] [li]Tadalafil 5mg once a day leads to a steady-state trough of 55 ng/mL, which corresponds to 90% PDE5 inhibition [style=font-style: italic;]in vitro[/style], which is the therapy standard likely to produce erections in most men.[/li] [li]It is recommended to not consume grapefruit, especially when on a daily dose protocol. It slows the excretion of tadalafil. The study suggests either on-demand exclusively and avoiding grapefruit before taking it, or the lowest possible daily dose(2.5mg once daily).[/li] [/ul] Based on what I know about grapefruit kinetics in the liver, liver processing of some [b][url=https://www.excelmale.com/how-to-increase-testosterone-naturally-2/]pharmaceuticals[/url][/b] will be slowed for 24 hours. If you use tadalafil on-demand and you have grapefruit or juice, wait at least 24 hours before taking a dose. Also, others on the forum have also suggested splitting the dosage of tadalafil and taking once every 12 hours. Compared to a single daily dose, this would raise the trough level, but lower the peak for a more regular plasma concentration. [/QUOTE]
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Cialis (Tadalafil) steady-state literature
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