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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Cialis (Tadalafil) steady-state blood level literature
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<blockquote data-quote="busgalloway" data-source="post: 103352" data-attributes="member: 16519"><p>There were two other papers from 2016 that agree with the study you posted from 2017 that shows a lack of evidence that sildenafil citrate and other PDE5 inhibitors, including tadalafil and vardenafil cause melanoma. Pottegård posited that increase in health-care contact led to early detection of the disease. Lian found that this small increase in melanoma correlates with patients that have over 7 prescriptions or take over 25 pills, but claims more validation is needed to prove it.</p><p><a href="https://www.nature.com/articles/bjc2016248" target="_blank">https://www.nature.com/articles/bjc2016248</a></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/27178449" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/27178449</a></p><p><a href="https://jamanetwork.com/journals/jama/fullarticle/2338254" target="_blank">https://jamanetwork.com/journals/jama/fullarticle/2338254</a></p><p></p><p>A paper from this year shows tadalafil causes a lowering of the threshold for myoclonic seizures in mice, but only at at the highest dose of 20mg/kg. It also seems to lower the efficacy of the anticonvulsant oxcarbazepine, but raises it for clonazepam.</p><p><a href="https://link.springer.com/article/10.1007%2Fs12640-018-9876-4" target="_blank">https://link.springer.com/article/10.1007/s12640-018-9876-4</a></p><p></p><p>I haven't seen much other literature risks other than these besides the side effects themselves. </p><p>There are many papers showing no cardiovascular harm from tadalafil, rather many show more benefits. I think the following paper describes each kind of effect, as well as explaining how the initial scares about these effects turned out to be because patients who already had cardiovascular disease were the ones that sought the aid of PDE5i prescriptions.</p><p><a href="https://www.tandfonline.com/doi/full/10.1517/14740338.7.1.43" target="_blank">https://www.tandfonline.com/doi/full/10.1517/14740338.7.1.43</a></p></blockquote><p></p>
[QUOTE="busgalloway, post: 103352, member: 16519"] There were two other papers from 2016 that agree with the study you posted from 2017 that shows a lack of evidence that sildenafil citrate and other PDE5 inhibitors, including tadalafil and vardenafil cause melanoma. Pottegård posited that increase in health-care contact led to early detection of the disease. Lian found that this small increase in melanoma correlates with patients that have over 7 prescriptions or take over 25 pills, but claims more validation is needed to prove it. [url]https://www.nature.com/articles/bjc2016248[/url] [url]https://www.ncbi.nlm.nih.gov/pubmed/27178449[/url] [url]https://jamanetwork.com/journals/jama/fullarticle/2338254[/url] A paper from this year shows tadalafil causes a lowering of the threshold for myoclonic seizures in mice, but only at at the highest dose of 20mg/kg. It also seems to lower the efficacy of the anticonvulsant oxcarbazepine, but raises it for clonazepam. [url]https://link.springer.com/article/10.1007%2Fs12640-018-9876-4[/url] I haven't seen much other literature risks other than these besides the side effects themselves. There are many papers showing no cardiovascular harm from tadalafil, rather many show more benefits. I think the following paper describes each kind of effect, as well as explaining how the initial scares about these effects turned out to be because patients who already had cardiovascular disease were the ones that sought the aid of PDE5i prescriptions. [url]https://www.tandfonline.com/doi/full/10.1517/14740338.7.1.43[/url] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Cialis (Tadalafil) steady-state blood level literature
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