ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Cialis (Tadalafil) steady-state blood level literature
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="busgalloway" data-source="post: 103244" data-attributes="member: 16519"><p>Thanks everybody. I should also mention that tadalafil's pharmacokinetics are linear. We tend to take this for granted, but not all medications are that simple.</p><p></p><p>In other words, doubling the dosage of tadalafil will double its plasma concentration. The excretion has a steady rate, so in half the time it takes to excrete all of it, the plasma concentration will halve. Makes sense right?</p><p></p><p>Well Viagra (Sildenafil Citrate) doesn't share this feature; after its initial spike in concentration, it is excreted through the body at a rate that looks like exponential decay. Food effects mostly dampen the initial concentration spike for the first 4 hours. Levitra (Vardenafil) also has a non-linear decay similar to Viagra, and research has been ongoing for a decade to eventually offer nebulizers as a form of vardenafil therapy, for faster onset and faster excretion to reduce side-effects.</p><p></p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874258/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874258/</a></p><p><a href="https://www.sciencedirect.com/science/article/pii/S1743609516300893" target="_blank">https://www.sciencedirect.com/science/article/pii/S1743609516300893</a></p></blockquote><p></p>
[QUOTE="busgalloway, post: 103244, member: 16519"] Thanks everybody. I should also mention that tadalafil's pharmacokinetics are linear. We tend to take this for granted, but not all medications are that simple. In other words, doubling the dosage of tadalafil will double its plasma concentration. The excretion has a steady rate, so in half the time it takes to excrete all of it, the plasma concentration will halve. Makes sense right? Well Viagra (Sildenafil Citrate) doesn't share this feature; after its initial spike in concentration, it is excreted through the body at a rate that looks like exponential decay. Food effects mostly dampen the initial concentration spike for the first 4 hours. Levitra (Vardenafil) also has a non-linear decay similar to Viagra, and research has been ongoing for a decade to eventually offer nebulizers as a form of vardenafil therapy, for faster onset and faster excretion to reduce side-effects. [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874258/[/URL] [URL]https://www.sciencedirect.com/science/article/pii/S1743609516300893[/URL] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Cialis (Tadalafil) steady-state blood level literature
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top