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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Chart showing rise in E2 with T injection?
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<blockquote data-quote="Cataceous" data-source="post: 208732" data-attributes="member: 38109"><p>Consider some extremes: daily injections versus weekly injections of testosterone cypionate with the same total weekly dose. Suppose that the daily injections yield fairly constant serum testosterone at about 600 ng/dL. Using the figures for young men in the paper I referenced above we find estradiol is 23 pg/mL and the aromatization rate is 0.39%. With these results, it would not be unusual for a single large weekly injection to yield a trough testosterone of around 350 ng/dL and a peak of around 850 ng/dL. The implication for estradiol is that saturation effects are more noticeable in the first part of the injection cycle, being most prominent at the peak and declining from there. At the peak, total estradiol is 30 pg/mL and the aromatization rate is indeed lower, at 0.36%. At the trough, estradiol is 15 pg/mL and the aromatization rate rises to 0.43%.</p><p></p><p>With weekly injections the aromatization rate is lower during the period of high estradiol. This means total estradiol produced each week is a little lower than with frequent injections. This is mainly of academic interest, because the effects of high peaks and low troughs in estradiol surely dwarf the effects of small variations in total production.</p><p></p><p>In this example the variation in the aromatization rate with weekly injections isn't extreme, going from 0.36% to 0.43%. Nonetheless, I can imagine that it could cause problems for more sensitive individuals, and in particular for those with low SHBG.</p><p></p><p>Of course then you can get into this question of why natural daily variation in testosterone and estradiol doesn't cause trouble. One hypothesis I'd toss out is that when testosterone varies relatively rapidly like that then the estradiol response is muted. The longer half-life of estradiol in serum might prevent peaks from being as high as when testosterone is varying more slowly, yet reaching the same peak and trough levels.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 208732, member: 38109"] Consider some extremes: daily injections versus weekly injections of testosterone cypionate with the same total weekly dose. Suppose that the daily injections yield fairly constant serum testosterone at about 600 ng/dL. Using the figures for young men in the paper I referenced above we find estradiol is 23 pg/mL and the aromatization rate is 0.39%. With these results, it would not be unusual for a single large weekly injection to yield a trough testosterone of around 350 ng/dL and a peak of around 850 ng/dL. The implication for estradiol is that saturation effects are more noticeable in the first part of the injection cycle, being most prominent at the peak and declining from there. At the peak, total estradiol is 30 pg/mL and the aromatization rate is indeed lower, at 0.36%. At the trough, estradiol is 15 pg/mL and the aromatization rate rises to 0.43%. With weekly injections the aromatization rate is lower during the period of high estradiol. This means total estradiol produced each week is a little lower than with frequent injections. This is mainly of academic interest, because the effects of high peaks and low troughs in estradiol surely dwarf the effects of small variations in total production. In this example the variation in the aromatization rate with weekly injections isn't extreme, going from 0.36% to 0.43%. Nonetheless, I can imagine that it could cause problems for more sensitive individuals, and in particular for those with low SHBG. Of course then you can get into this question of why natural daily variation in testosterone and estradiol doesn't cause trouble. One hypothesis I'd toss out is that when testosterone varies relatively rapidly like that then the estradiol response is muted. The longer half-life of estradiol in serum might prevent peaks from being as high as when testosterone is varying more slowly, yet reaching the same peak and trough levels. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Chart showing rise in E2 with T injection?
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