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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
CDC's Clinical Standardization Programs: Free Testosterone soon to be!
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<blockquote data-quote="madman" data-source="post: 236377" data-attributes="member: 13851"><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/reference-intervals-for-free-testosterone-in-adult-men-measured-using-a-standardized-equilibrium-dialysis-procedure.26279/[/URL]</p><p></p><p>Critical take-home points:</p><p></p><p><strong><em>*Using this standardized equilibrium dialysis method coupled with a HoST-certified LC-MS/MS assay for measuring testosterone in the dialysate, described in detail here to enable its easy replication across laboratories, we report for the first time the distribution of free testosterone levels in a prospectively collected sample of carefully screened healthy men, 19 years or older. The range of free testosterone levels (2.5th to 97.5th percentile values) in healthy nonobese men, 19 years or older, is 66 to 309 pg/mL (229 to 1072 pmol/L), and in a reference sample of nonobese healthy young men, 19 to 39 years, is 120 to 368 pg/mL (415 to 1274 pmol/L). The distribution of free testosterone levels by age group is also reported. <u>These normative data can potentially be applied after appropriate cross-calibration to other laboratories that perform the equilibrium dialysis under similar standardized conditions and use a testosterone assay that is certified by an accuracy-based standardization program such as the Center for Disease Control and Prevention's HoST program</u>. <u>Further studies are needed to determine how these reference intervals apply to the diagnosis of androgen deficiency in clinical populations and in men of different races and ethnicities in different geographic regions</u></em></strong></p><p><strong><em></em></strong></p><p><strong><em>*<strong><em>These reference ranges, generated in a reference sample of healthy men, <u>should not be applied to other assays in other laboratories without appropriate cross-calibration of assays</u>. Differences in study populations, time of sample collection, and testosterone assays can contribute to the differences in reference ranges. <u>The adoption of a standardized procedure for measuring free testosterone and cross-calibration of the testosterone assays against an accuracy-based benchmark such as the CDC's HoST program will facilitate the application of these reference ranges across laboratories</u></em></strong></em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 236377, member: 13851"] [URL unfurl="true"]https://www.excelmale.com/forum/threads/reference-intervals-for-free-testosterone-in-adult-men-measured-using-a-standardized-equilibrium-dialysis-procedure.26279/[/URL] Critical take-home points: [B][I]*Using this standardized equilibrium dialysis method coupled with a HoST-certified LC-MS/MS assay for measuring testosterone in the dialysate, described in detail here to enable its easy replication across laboratories, we report for the first time the distribution of free testosterone levels in a prospectively collected sample of carefully screened healthy men, 19 years or older. The range of free testosterone levels (2.5th to 97.5th percentile values) in healthy nonobese men, 19 years or older, is 66 to 309 pg/mL (229 to 1072 pmol/L), and in a reference sample of nonobese healthy young men, 19 to 39 years, is 120 to 368 pg/mL (415 to 1274 pmol/L). The distribution of free testosterone levels by age group is also reported. [U]These normative data can potentially be applied after appropriate cross-calibration to other laboratories that perform the equilibrium dialysis under similar standardized conditions and use a testosterone assay that is certified by an accuracy-based standardization program such as the Center for Disease Control and Prevention's HoST program[/U]. [U]Further studies are needed to determine how these reference intervals apply to the diagnosis of androgen deficiency in clinical populations and in men of different races and ethnicities in different geographic regions[/U] *[B][I]These reference ranges, generated in a reference sample of healthy men, [U]should not be applied to other assays in other laboratories without appropriate cross-calibration of assays[/U]. Differences in study populations, time of sample collection, and testosterone assays can contribute to the differences in reference ranges. [U]The adoption of a standardized procedure for measuring free testosterone and cross-calibration of the testosterone assays against an accuracy-based benchmark such as the CDC's HoST program will facilitate the application of these reference ranges across laboratories[/U][/I][/B][/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
CDC's Clinical Standardization Programs: Free Testosterone soon to be!
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