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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
CARDIOVASCULAR AND METABOLIC ACTIONS OF THE ANDROGENS
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<blockquote data-quote="madman" data-source="post: 239211" data-attributes="member: 13851"><p><strong>Fig. 1. <u>Classical biochemical pathways for synthesis of C19 Androstanes (Testosterone, TES) in males by the Leydig Cells in the testes</u>. TES biosynthesis may proceed by either the 4 pathway (via androstenedione, green pathway) or 5 pathway (via DHEA and androstenediol, red pathway), intermediates are not shown. Once secreted, circulating TES is subsequently metabolized in peripheral target tissues to the highly potent tissue androgen 5- dihydrotestosterone (5-DHT) or to the genomically inactive isomer 5-DHT. TES is also metabolized in some peripheral tissues, especially adipose, to the C18 Estranes (17-Estradiol or Estrone). These pathways are also active in females in the ovarian follicle: thecal cells synthesize TES which is then aromatized by neighboring Granulosa cells to 17-Estradiol. Enzymes involved: 1) 3-HSD, 3-hydroxysteroid dehydrogenase/D5-isomerase; 2) Aromatase; 3) 17-HSD, 17-hydroxysteroid dehydrogenase; 4) 5-reductase; 5) 5-reductase. Redrawn from Perusquia, 2022 [122].</strong></p><p><strong>[ATTACH=full]26926[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 239211, member: 13851"] [B]Fig. 1. [U]Classical biochemical pathways for synthesis of C19 Androstanes (Testosterone, TES) in males by the Leydig Cells in the testes[/U]. TES biosynthesis may proceed by either the 4 pathway (via androstenedione, green pathway) or 5 pathway (via DHEA and androstenediol, red pathway), intermediates are not shown. Once secreted, circulating TES is subsequently metabolized in peripheral target tissues to the highly potent tissue androgen 5- dihydrotestosterone (5-DHT) or to the genomically inactive isomer 5-DHT. TES is also metabolized in some peripheral tissues, especially adipose, to the C18 Estranes (17-Estradiol or Estrone). These pathways are also active in females in the ovarian follicle: thecal cells synthesize TES which is then aromatized by neighboring Granulosa cells to 17-Estradiol. Enzymes involved: 1) 3-HSD, 3-hydroxysteroid dehydrogenase/D5-isomerase; 2) Aromatase; 3) 17-HSD, 17-hydroxysteroid dehydrogenase; 4) 5-reductase; 5) 5-reductase. Redrawn from Perusquia, 2022 [122]. [ATTACH type="full"]26926[/ATTACH][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
CARDIOVASCULAR AND METABOLIC ACTIONS OF THE ANDROGENS
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