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Cardarine
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<blockquote data-quote="BigTex" data-source="post: 255379" data-attributes="member: 43589"><p>First off, this single study study involved in administering Cardarine to Han Wistar rats for almost two years straight. No one is going to do Cardarine for that long. Second, the median life expectancy of Han Wistar rats is between 30 to 33 months for females and 33 to 36 months for males. So human equivalent, that would be like doing Cardarine every day from the majority of your life. Third, The dosages administered to rats over the two-year study varied widely, but the lowest dosage showing cancer cell proliferation in the rodent model was 3 mg/kg/day in Han Wistar rats for a period of 104 weeks. For an 80 kg human male, you be taking about 45mg for the 2/3 of your life.</p><p></p><p>In all of the clinical studies conducted on humans using dosages as high as 10 mg per day for 12 weeks, no serious adverse effects or cancer development was reported. The suggested dose for Cardarine is 10mg/d.</p><p></p><p>[URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/21816786/[/URL]</p><p></p><p>[URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/22814748/[/URL]</p><p></p><p>[URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/17110604/[/URL]</p><p></p><p>Last thing to remember is rat studies do not necessarily mean the same thing will happen with humans. If there were a huge concern over cancer, the first report of a PPARdelta agonist administered to man would have never taken place. In short, this flawed study proving that Cardarine caused cancer used rats that were prone to getting cancer in the first place. All this being said, I would keep the dose at 5-10mg/d and very short duration <12wks. Also remember that this is a banned substance in the military and any athletic event that tests for performance drugs.</p><p></p><p>[URL unfurl="true"]https://sitn.hms.harvard.edu/flash/2020/why-drugs-tested-in-mice-fail-in-human-clinical-trials/[/URL]</p><p></p><p>Here is another one I found....see the discussion </p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614479/[/URL]</p></blockquote><p></p>
[QUOTE="BigTex, post: 255379, member: 43589"] First off, this single study study involved in administering Cardarine to Han Wistar rats for almost two years straight. No one is going to do Cardarine for that long. Second, the median life expectancy of Han Wistar rats is between 30 to 33 months for females and 33 to 36 months for males. So human equivalent, that would be like doing Cardarine every day from the majority of your life. Third, The dosages administered to rats over the two-year study varied widely, but the lowest dosage showing cancer cell proliferation in the rodent model was 3 mg/kg/day in Han Wistar rats for a period of 104 weeks. For an 80 kg human male, you be taking about 45mg for the 2/3 of your life. In all of the clinical studies conducted on humans using dosages as high as 10 mg per day for 12 weeks, no serious adverse effects or cancer development was reported. The suggested dose for Cardarine is 10mg/d. [URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/21816786/[/URL] [URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/22814748/[/URL] [URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/17110604/[/URL] Last thing to remember is rat studies do not necessarily mean the same thing will happen with humans. If there were a huge concern over cancer, the first report of a PPARdelta agonist administered to man would have never taken place. In short, this flawed study proving that Cardarine caused cancer used rats that were prone to getting cancer in the first place. All this being said, I would keep the dose at 5-10mg/d and very short duration <12wks. Also remember that this is a banned substance in the military and any athletic event that tests for performance drugs. [URL unfurl="true"]https://sitn.hms.harvard.edu/flash/2020/why-drugs-tested-in-mice-fail-in-human-clinical-trials/[/URL] Here is another one I found....see the discussion [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614479/[/URL] [/QUOTE]
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