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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Can your testosterone levels recover when you stop opiates?
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<blockquote data-quote="madman" data-source="post: 237076" data-attributes="member: 13851"><p>*<strong><em>Guidelines support screening for testosterone deficiency in this situation. Consideration should be given to screening for testosterone deficiency prior to an opioid prescription, to provide a baseline. <u>From a clinical point of view, the effect is reversible and if the opioid is removed, the deficiency is reversed, usually within a month</u></em></strong></p><p></p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/opioid-induced-hypogonadism.25565/[/URL]</p><p></p><p></p><p><strong>*Impact of opioids on the male endocrine system</strong></p><p><strong></strong></p><p><strong><em>The endocrine system can be severely affected by chronic opioid treatment, leading to a decrease in total testosterone levels and opioid-induced hypogonadism (Figure 2).</em></strong><em> Opioids depress the secretion of hormones at different levels of the hypothalamic-pituitary-gonadal axis and generally increase levels of growth hormone, thyroid-stimulating hormone, and prolactin, but there are conflicting reports on the effects of opioids on arginine, vasopressin, and adrenocorticotropic hormone. In addition, opioids can lead to the development of hypogonadism by directly inhibiting gonadotropin-releasing hormone (GnRH) through the μ-opioid receptor, reducing libido and causing erectile dysfunction (ED), bone loss, and/or infertility.14</em></p><p><em></em></p><p><em><strong><u>The impact occurs rapidly, often within one week, and the highest risk appears to be among patients receiving significant dosages for longer than one month</u>. <u>The use</u><em><u> of the more potent opioids is more likely to cause a greater risk of hypogonadism, but the effects seem to be reversible after a few days of withdrawal</u>.</em> As one might expect, long-acting opioids have a greater risk compared with short-acting drugs. There is a significant correlation between increased dosage and the development of opioid-induced androgen deficiency (OPIAD).14</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong><u>The prevalence of OPIAD ranges from 19% to 86%, with most studies reporting an overall prevalence higher than 50%, confirming the significant impact of opioids in reducing testosterone levels</u>.14,17,18 <u>Figure 3</u> shows the prevalence of low testosterone among chronic opioid users and men with other conditions.19</strong></em></p><p></p><p><strong><em><u>A systematic review and meta-analysis of testosterone suppression in opioid users concluded that testosterone level was suppressed in men with regular opioid use regardless of the opioid type</u> and found a mean testosterone difference of 5.7nmol/L between opioid users and controls. Opioids were found to affect testosterone levels differently in men than women, and testosterone was not found to be suppressed in studies examining opioid-using women.20</em></strong></p><p></p><p><em><strong>Opioids can induce several hypogonadism-related signs and symptoms, including sexual dysfunction, mood impairment, fatigue, obesity and cardiovascular disease, osteoporosis, and sexual dysfunction.</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 237076, member: 13851"] *[B][I]Guidelines support screening for testosterone deficiency in this situation. Consideration should be given to screening for testosterone deficiency prior to an opioid prescription, to provide a baseline. [U]From a clinical point of view, the effect is reversible and if the opioid is removed, the deficiency is reversed, usually within a month[/U][/I][/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/opioid-induced-hypogonadism.25565/[/URL] [B]*Impact of opioids on the male endocrine system [I]The endocrine system can be severely affected by chronic opioid treatment, leading to a decrease in total testosterone levels and opioid-induced hypogonadism (Figure 2).[/I][/B][I] Opioids depress the secretion of hormones at different levels of the hypothalamic-pituitary-gonadal axis and generally increase levels of growth hormone, thyroid-stimulating hormone, and prolactin, but there are conflicting reports on the effects of opioids on arginine, vasopressin, and adrenocorticotropic hormone. In addition, opioids can lead to the development of hypogonadism by directly inhibiting gonadotropin-releasing hormone (GnRH) through the μ-opioid receptor, reducing libido and causing erectile dysfunction (ED), bone loss, and/or infertility.14 [B][U]The impact occurs rapidly, often within one week, and the highest risk appears to be among patients receiving significant dosages for longer than one month[/U]. [U]The use[/U][I][U] of the more potent opioids is more likely to cause a greater risk of hypogonadism, but the effects seem to be reversible after a few days of withdrawal[/U].[/I] As one might expect, long-acting opioids have a greater risk compared with short-acting drugs. There is a significant correlation between increased dosage and the development of opioid-induced androgen deficiency (OPIAD).14 [U]The prevalence of OPIAD ranges from 19% to 86%, with most studies reporting an overall prevalence higher than 50%, confirming the significant impact of opioids in reducing testosterone levels[/U].14,17,18 [U]Figure 3[/U] shows the prevalence of low testosterone among chronic opioid users and men with other conditions.19[/B][/I] [B][I][U]A systematic review and meta-analysis of testosterone suppression in opioid users concluded that testosterone level was suppressed in men with regular opioid use regardless of the opioid type[/U] and found a mean testosterone difference of 5.7nmol/L between opioid users and controls. Opioids were found to affect testosterone levels differently in men than women, and testosterone was not found to be suppressed in studies examining opioid-using women.20[/I][/B] [I][B]Opioids can induce several hypogonadism-related signs and symptoms, including sexual dysfunction, mood impairment, fatigue, obesity and cardiovascular disease, osteoporosis, and sexual dysfunction.[/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Can your testosterone levels recover when you stop opiates?
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