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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck
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<blockquote data-quote="Marco N Cognito" data-source="post: 14885" data-attributes="member: 13"><p>The FVIII (and vWF - which is essentially the same thing) that were elevated can be familial or can be acute phase reactants or both. That is why more repeat testing must be done. </p><p></p><p>Here is how dangerous elevated FVIII is (in terms of thrombosis) and too little is (in terms of hemophilia):</p><p><a href="http://atvb.ahajournals.org/content/21/5/731.fullhttp://www.jabfm.org/content/18/4/328.fullhttp://en.wikipedia.org/wiki/Factor_VIII" target="_blank">http://atvb.ahajournals.org/content/21/5/731.fullhttp://www.jabfm.org/content/18/4/328.fullhttp://en.wikipedia.org/wiki/Factor_VIII</a></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/10669145" target="_blank">http://www.ncbi.nlm.nih.gov/pubmed/10669145</a></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/12567199" target="_blank">http://www.ncbi.nlm.nih.gov/pubmed/12567199</a></p><p><a href="http://en.wikipedia.org/wiki/Factor_VIII" target="_blank">http://en.wikipedia.org/wiki/Factor_VIII</a></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/9184386" target="_blank">http://www.ncbi.nlm.nih.gov/pubmed/9184386</a></p><p><a href="http://www.wisegeek.com/what-is-factor-viii.htm" target="_blank">http://www.wisegeek.com/what-is-factor-viii.htm</a></p><p><a href="http://www.jaoa.osteopathic.org/content/112/3/140.full.pdf" target="_blank">http://www.jaoa.osteopathic.org/content/112/3/140.full.pdf</a></p><p></p><p>Although few, if any, physicians' knowledge base encompasses even a slight understanding of this link (most likely because it is limited to a minority of prone individuals), there are nonetheless several papers showing such between an <u>excess</u> of exogenous thyroid hormone and thrombosis. Here are most of the links to my research on how excess thyroid hormone (T3 or T4) induces a hypercoagulable state, making one prone to thrombotic events:</p><p><a href="http://www.bloodjournal.org/content/115/22/4344.full?sso-checked=true" target="_blank">http://www.bloodjournal.org/content/115/22/4344.full?sso-checked=true</a></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/3659809" target="_blank">http://www.ncbi.nlm.nih.gov/pubmed/3659809</a></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/21249601" target="_blank">http://www.ncbi.nlm.nih.gov/pubmed/21249601</a></p><p><a href="http://press.endocrine.org/doi/full/10.1210/jc.2007-0199" target="_blank">http://press.endocrine.org/doi/full/10.1210/jc.2007-0199</a></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/6814317" target="_blank">http://www.ncbi.nlm.nih.gov/pubmed/6814317</a></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/6411844" target="_blank">http://www.ncbi.nlm.nih.gov/pubmed/6411844</a></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/5304832" target="_blank">http://www.ncbi.nlm.nih.gov/pubmed/5304832</a></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/11288984" target="_blank">http://www.ncbi.nlm.nih.gov/pubmed/11288984</a></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/21257724" target="_blank">http://www.ncbi.nlm.nih.gov/pubmed/21257724</a></p><p><a href="http://annals.org/article.aspx?articleid=696027" target="_blank">http://annals.org/article.aspx?articleid=696027</a></p><p><a href="http://www.researchgate.net/publication/21533215_Arginine-vasopressin_and_endothelium-associated_proteins_in_thyroid_disease" target="_blank">http://www.researchgate.net/publication/21533215_Arginine-vasopressin_and_endothelium-associated_proteins_in_thyroid_disease</a></p><p><a href="http://press.endocrine.org/doi/full/10.1210/jc.2007-0199" target="_blank">http://press.endocrine.org/doi/full/10.1210/jc.2007-0199</a></p><p></p><p>The question therefore is: what is considered excess exogenous thyroid replacement? Just because one's thyroid labs are within range doesn't mean they aren't getting too much replacement, as there could be issues such as pooling, thyroid hormone resistance, etc. Everyone is unique. When the body doesn't need something that is being forced upon it in amounts over what it produces naturally, it will react in various way. One is inflammation. FVIII is an acute phase reactant that will elevate when the individual is stressed or inflamed. Overtraining will increase FVIII levels transiently, for example. This tells us that there isn't always a genetic cause to an abnormal level. </p><p></p><p>Anecdotally, since I've reduced my overall thyroid replacement, my FVIII and vWF markers have dropped as I suspected.</p><p></p><p>Again, in my case, I have none of the other markers that are strictly familial other than MTHFR c677T +/+, but that is considered only weakly thrombogenic according to Glueck and beyond keeping one's methylation balance and homocysteine in check, there is no evidence to suggest it has any further effects on thrombosis. BTW, I check my thyroid markers every month, so I'm on top of it! Hematologists know very little about this research. Also, hyperparathyroidism can induce hypercoagulation. In July, I had a parathyroid tumor removed, so this is yet another facet of what could contribute to non-familial thrombophilia. It is unlikely that there is just one factor that contributes to this pathology, let alone any. Time will tell all. As with any pharmaceutical intervention, there is ALWAYS a risk, even with Xarelto prophylaxis, as it is so new AND there is still no commercially-available anecdote for it if you start to hemorrhage. So, unless one has documented proof of a life-threatening familial coagulation disorder (i.e. Factor 5 Leiden, etc.), to ban those of us who are full-blown hypogonadal or borderline hypogonadal from the benefits of TRT is depriving us of a quality of life. </p><p></p><p>Did your clot occur while toy were on Xarelto? What dose are you on now?</p></blockquote><p></p>
[QUOTE="Marco N Cognito, post: 14885, member: 13"] The FVIII (and vWF - which is essentially the same thing) that were elevated can be familial or can be acute phase reactants or both. That is why more repeat testing must be done. Here is how dangerous elevated FVIII is (in terms of thrombosis) and too little is (in terms of hemophilia): [URL]http://atvb.ahajournals.org/content/21/5/731.fullhttp://www.jabfm.org/content/18/4/328.fullhttp://en.wikipedia.org/wiki/Factor_VIII[/URL] [URL]http://www.ncbi.nlm.nih.gov/pubmed/10669145[/URL] [URL]http://www.ncbi.nlm.nih.gov/pubmed/12567199[/URL] [URL]http://en.wikipedia.org/wiki/Factor_VIII[/URL] [URL]http://www.ncbi.nlm.nih.gov/pubmed/9184386[/URL] [URL]http://www.wisegeek.com/what-is-factor-viii.htm[/URL] [URL]http://www.jaoa.osteopathic.org/content/112/3/140.full.pdf[/URL] Although few, if any, physicians' knowledge base encompasses even a slight understanding of this link (most likely because it is limited to a minority of prone individuals), there are nonetheless several papers showing such between an [U]excess[/U] of exogenous thyroid hormone and thrombosis. Here are most of the links to my research on how excess thyroid hormone (T3 or T4) induces a hypercoagulable state, making one prone to thrombotic events: [URL]http://www.bloodjournal.org/content/115/22/4344.full?sso-checked=true[/URL] [URL]http://www.ncbi.nlm.nih.gov/pubmed/3659809[/URL] [URL]http://www.ncbi.nlm.nih.gov/pubmed/21249601[/URL] [URL]http://press.endocrine.org/doi/full/10.1210/jc.2007-0199[/URL] [URL]http://www.ncbi.nlm.nih.gov/pubmed/6814317[/URL] [URL]http://www.ncbi.nlm.nih.gov/pubmed/6411844[/URL] [URL]http://www.ncbi.nlm.nih.gov/pubmed/5304832[/URL] [URL]http://www.ncbi.nlm.nih.gov/pubmed/11288984[/URL] [URL]http://www.ncbi.nlm.nih.gov/pubmed/21257724[/URL] [URL]http://annals.org/article.aspx?articleid=696027[/URL] [URL]http://www.researchgate.net/publication/21533215_Arginine-vasopressin_and_endothelium-associated_proteins_in_thyroid_disease[/URL] [URL]http://press.endocrine.org/doi/full/10.1210/jc.2007-0199[/URL] The question therefore is: what is considered excess exogenous thyroid replacement? Just because one's thyroid labs are within range doesn't mean they aren't getting too much replacement, as there could be issues such as pooling, thyroid hormone resistance, etc. Everyone is unique. When the body doesn't need something that is being forced upon it in amounts over what it produces naturally, it will react in various way. One is inflammation. FVIII is an acute phase reactant that will elevate when the individual is stressed or inflamed. Overtraining will increase FVIII levels transiently, for example. This tells us that there isn't always a genetic cause to an abnormal level. Anecdotally, since I've reduced my overall thyroid replacement, my FVIII and vWF markers have dropped as I suspected. Again, in my case, I have none of the other markers that are strictly familial other than MTHFR c677T +/+, but that is considered only weakly thrombogenic according to Glueck and beyond keeping one's methylation balance and homocysteine in check, there is no evidence to suggest it has any further effects on thrombosis. BTW, I check my thyroid markers every month, so I'm on top of it! Hematologists know very little about this research. Also, hyperparathyroidism can induce hypercoagulation. In July, I had a parathyroid tumor removed, so this is yet another facet of what could contribute to non-familial thrombophilia. It is unlikely that there is just one factor that contributes to this pathology, let alone any. Time will tell all. As with any pharmaceutical intervention, there is ALWAYS a risk, even with Xarelto prophylaxis, as it is so new AND there is still no commercially-available anecdote for it if you start to hemorrhage. So, unless one has documented proof of a life-threatening familial coagulation disorder (i.e. Factor 5 Leiden, etc.), to ban those of us who are full-blown hypogonadal or borderline hypogonadal from the benefits of TRT is depriving us of a quality of life. Did your clot occur while toy were on Xarelto? What dose are you on now? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck
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