ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Expert Interviews
Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Marco N Cognito" data-source="post: 5547" data-attributes="member: 13"><p>Thanks to Nelson's efforts above, for those of us that have any incidence of familial or acquired incidence of blood clots or/and that have a prior history (as I do), we now have a thread on this topic to post ongoing concerns and updates for all to benefit from.</p><p></p><p>I will be contacting Dr. Glueck with my concerns and report back in hopes I can ascertain some type of more aggressively-managed protocol for those of us at risk or who suspect risk while commencing TRT. Warfarin (coumadin) is only one type of anticoagulant, acting as a Vit K antagonist, blocking its action, and aspirin (and prescription anticoagulants like Plavix) only works to prevent platelet aggregation, however, there are other anticoagulants that work upon the clotting cascade entirely differently that as far as I know were not used in his research. These would be the older ones, i.e. Lovenox, heparin, and the much newer direct thrombin inhibitors like Xarelto, Eliquis and Pradaxa. </p><p></p><p>As far as AIs to control E2, I am at a loss as to what will not affect the clotting cascade in some way; they all do. Perhaps natural AIs are thew only safe ones. In my case, I have the opposite issue, as my E2 is almost non-existent. Yet another argument in favor of TRT.</p><p></p><p>Also &#8211; it would be interesting to see if having therapeutic phlebotomies would have prevented clots in those subject.</p><p></p><p>In opposition to Glueck's work is this 1990 study which states that AAS is NOT thrombogenic: <a href="http://www.nejm.org/doi/full/10.1056/NEJM199002153220716" target="_blank">http://www.nejm.org/doi/full/10.1056/NEJM199002153220716</a></p><p></p><p>In the meantime, here is my own doc's take, given my past history of clots:</p><p>"<em>I did not see any mortality data, just recurrent DVT with the T treatment. We have a large volume of data showing decreased mortality from all causes with testosterone replacement therapy vs no treatment for low T patients, let alone the subjective improvement in the quality of life. Also, even though ONE patient had DVT with a normal E2 level, most had high levels of E2. </em></p><p><em></em></p><p><em>You would have to balance risk vs benefits for your particular case with an increased risk for thrombosis, although the case numbers appear to be very small. Really, there is no right or wrong avenue to take. Risks treating as well as risks for not treating, you need to decide which are more important for you. It appears by % and numbers that reducing MI's by T treatment could outweigh the risk of thrombosis by case numbers and %, but you ultimately need to decide what scares you more." </em></p><p></p><p>Some further data:</p><p></p><p><strong>1) There have been 10 cases with major gene thrombophilia FULLY ANTICOAGULATED (with warfarin) who had second or even third thrombotic events when exogenous T therapy was continued.</strong></p><p><strong></strong></p><p><strong>2) There is one case in which Arimidex by itself caused thrombosis in a V Leiden heterozygote. </strong></p><p></p><p>Glueck's actual studies:</p><p></p><p>This is not a black and white issue and there are many offsetting factors like elevated Lp(a) which may have a link between thrombosis and atherosclerosis, interfering with plasminogen function in the fibrinolytic cascade. Exogenous T acts as a fibrinolytic and is use as a protocol to lower Lp(a) in men. </p><p> </p><p>With the aggressive marketing of global TRT clinics, I expect we will see an incidence of thrombotic events increasing as more men commence TRT. This will greatly increase the necessity to overcome the hurdle as to what prophylactic measures can be taken to prevent future episodes, some of which can be fatal in the event a DVT causes PE.</p></blockquote><p></p>
[QUOTE="Marco N Cognito, post: 5547, member: 13"] Thanks to Nelson's efforts above, for those of us that have any incidence of familial or acquired incidence of blood clots or/and that have a prior history (as I do), we now have a thread on this topic to post ongoing concerns and updates for all to benefit from. I will be contacting Dr. Glueck with my concerns and report back in hopes I can ascertain some type of more aggressively-managed protocol for those of us at risk or who suspect risk while commencing TRT. Warfarin (coumadin) is only one type of anticoagulant, acting as a Vit K antagonist, blocking its action, and aspirin (and prescription anticoagulants like Plavix) only works to prevent platelet aggregation, however, there are other anticoagulants that work upon the clotting cascade entirely differently that as far as I know were not used in his research. These would be the older ones, i.e. Lovenox, heparin, and the much newer direct thrombin inhibitors like Xarelto, Eliquis and Pradaxa. As far as AIs to control E2, I am at a loss as to what will not affect the clotting cascade in some way; they all do. Perhaps natural AIs are thew only safe ones. In my case, I have the opposite issue, as my E2 is almost non-existent. Yet another argument in favor of TRT. Also – it would be interesting to see if having therapeutic phlebotomies would have prevented clots in those subject. In opposition to Glueck's work is this 1990 study which states that AAS is NOT thrombogenic: [URL]http://www.nejm.org/doi/full/10.1056/NEJM199002153220716[/URL] In the meantime, here is my own doc's take, given my past history of clots: "[I]I did not see any mortality data, just recurrent DVT with the T treatment. We have a large volume of data showing decreased mortality from all causes with testosterone replacement therapy vs no treatment for low T patients, let alone the subjective improvement in the quality of life. Also, even though ONE patient had DVT with a normal E2 level, most had high levels of E2. You would have to balance risk vs benefits for your particular case with an increased risk for thrombosis, although the case numbers appear to be very small. Really, there is no right or wrong avenue to take. Risks treating as well as risks for not treating, you need to decide which are more important for you. It appears by % and numbers that reducing MI's by T treatment could outweigh the risk of thrombosis by case numbers and %, but you ultimately need to decide what scares you more." [/I] Some further data: [B]1) There have been 10 cases with major gene thrombophilia FULLY ANTICOAGULATED (with warfarin) who had second or even third thrombotic events when exogenous T therapy was continued. 2) There is one case in which Arimidex by itself caused thrombosis in a V Leiden heterozygote. [/B] Glueck's actual studies: This is not a black and white issue and there are many offsetting factors like elevated Lp(a) which may have a link between thrombosis and atherosclerosis, interfering with plasminogen function in the fibrinolytic cascade. Exogenous T acts as a fibrinolytic and is use as a protocol to lower Lp(a) in men. With the aggressive marketing of global TRT clinics, I expect we will see an incidence of thrombotic events increasing as more men commence TRT. This will greatly increase the necessity to overcome the hurdle as to what prophylactic measures can be taken to prevent future episodes, some of which can be fatal in the event a DVT causes PE. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Expert Interviews
Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top