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Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck
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<blockquote data-quote="Nelson Vergel" data-source="post: 18560" data-attributes="member: 3"><p><strong>Clot Risk Not Higher in Older Men Taking Testosterone</strong></p><p></p><p></p><p>"Dr Ramasamy and his colleagues retrospectively reviewed the medical records of 217 hypogonadal men older than 65 years.Of the 153 men who received testosterone therapy, 53 were treated with injections, 47 were treated with gel, and 53 were treated with pellets, which are placed intramuscularly beneath the skin. The remaining 64 men did not receive testosterone therapy.</p><p></p><p>Median follow-up was similar in the treated and untreated groups (3.8 vs 3.5 years), and median age was 74 to 75 in the two groups.</p><p></p><p></p><p>There were fewer deaths in the treated than in the untreated group (1 vs 6; <em>P</em> = .003). In addition, there were more myocardial infarctions in the treated than in the untreated group (1 vs 0), more cerebrovascular accidents (2 vs 1), and more pulmonary embolisms (1 vs 0), but these differences were not significant.</p><p></p><p>"One of the limitations of the study is its small sample size," Dr Ramasamy acknowledged.</p><p> </p><p>We can confidently say that the risk of thrombosis does not appear to be higher in men who are treated. </p><p></p><p>However, unlike in epidemiologic studies, "the biggest advantage of our study is that we actually saw these patients, we treated them, we know what their testosterone levels were, we managed them appropriately, and we followed them," he explained. Therefore, "despite the small sample size, the study lends a lot more validity to the argument that testosterone therapy does not appear to increase the development of thrombotic events."</p><p></p><p><a href="http://www.medscape.com/viewarticle/844816#vp_2" target="_blank">http://www.medscape.com/viewarticle/844816#vp_2</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 18560, member: 3"] [B]Clot Risk Not Higher in Older Men Taking Testosterone[/B] "Dr Ramasamy and his colleagues retrospectively reviewed the medical records of 217 hypogonadal men older than 65 years.Of the 153 men who received testosterone therapy, 53 were treated with injections, 47 were treated with gel, and 53 were treated with pellets, which are placed intramuscularly beneath the skin. The remaining 64 men did not receive testosterone therapy. Median follow-up was similar in the treated and untreated groups (3.8 vs 3.5 years), and median age was 74 to 75 in the two groups. There were fewer deaths in the treated than in the untreated group (1 vs 6; [I]P[/I] = .003). In addition, there were more myocardial infarctions in the treated than in the untreated group (1 vs 0), more cerebrovascular accidents (2 vs 1), and more pulmonary embolisms (1 vs 0), but these differences were not significant. "One of the limitations of the study is its small sample size," Dr Ramasamy acknowledged. We can confidently say that the risk of thrombosis does not appear to be higher in men who are treated. However, unlike in epidemiologic studies, "the biggest advantage of our study is that we actually saw these patients, we treated them, we know what their testosterone levels were, we managed them appropriately, and we followed them," he explained. Therefore, "despite the small sample size, the study lends a lot more validity to the argument that testosterone therapy does not appear to increase the development of thrombotic events." [URL]http://www.medscape.com/viewarticle/844816#vp_2[/URL] [/QUOTE]
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Expert Interviews
Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck
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