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Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck
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<blockquote data-quote="Nelson Vergel" data-source="post: 15900" data-attributes="member: 3"><p><strong>Testosterone therapy, thrombophilia, and hospitalization for deep venous thrombosis-pulmonary embolus, an exploratory, hypothesis-generating study - Abstract</strong></p><p></p><p></p><p>Our hypothesis was that testosterone therapy (TT) interacts with previously undiagnosed thrombophilia-hypofibrinolysis, leading to hospitalization for deep venous thrombosis (DVT)-pulmonary emboli (PE).</p><p></p><p>We determined the prevalence of DVT-PE associated with TT 147 men hospitalized in the last 12months for DVT-PE. Of the 147 men, 2 (1.4%) had TT before and at the time of their DVT-PE. Neither had risk factors for thrombosis. Neither smoked. Case #1 (intramuscular T 50mg/week) had 2 PE, 6 and 24months after starting TT. DVT-PE in case #2 (T gel 100mg/day) occurred 24months after starting T. Both men were found to have previously undiagnosed familial thrombophilia (protein S deficiency, homocysteinemia, high Factor VIII). In case #2, on 100mg T gel/day, serum estradiol was high, 51pg/ml (upper normal limit 42.6pg/ml). At least 1.4% of men hospitalized for DVT-PE were on TT and had previously undiagnosed thrombophilia, suggesting a thrombotic interaction between exogenous T and thrombophilia-hypofibrinolysis. Given the increasing use of TT, our preliminary findings should facilitate design of a much-needed, multi-center, prospective study of pro-thrombotic interactions between T therapy and thrombophilia for subsequent thrombotic events including DVT-PE.</p><p></p><p><strong>Written by:</strong> </p><p>Glueck CJ, Friedman J, Hafeez A, Hassan A, Wang P. </p><p><em>Jewish Hospital Cholesterol Center, Jewish Hospital of Cincinnati, United States; Internal Medicine Residency Program, Jewish Hospital of Cincinnati, United States. <a href="mailto:cjglueck@health-partners.org">cjglueck@health-partners.org</a></em></p><p><strong>Reference:</strong> Med Hypotheses. 2015 Jan 21. pii: S0306-9877(15)00041-9. </p><p><strong>doi:</strong> 10.1016/j.mehy.2015.01.020.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 15900, member: 3"] [B]Testosterone therapy, thrombophilia, and hospitalization for deep venous thrombosis-pulmonary embolus, an exploratory, hypothesis-generating study - Abstract[/B] Our hypothesis was that testosterone therapy (TT) interacts with previously undiagnosed thrombophilia-hypofibrinolysis, leading to hospitalization for deep venous thrombosis (DVT)-pulmonary emboli (PE). We determined the prevalence of DVT-PE associated with TT 147 men hospitalized in the last 12months for DVT-PE. Of the 147 men, 2 (1.4%) had TT before and at the time of their DVT-PE. Neither had risk factors for thrombosis. Neither smoked. Case #1 (intramuscular T 50mg/week) had 2 PE, 6 and 24months after starting TT. DVT-PE in case #2 (T gel 100mg/day) occurred 24months after starting T. Both men were found to have previously undiagnosed familial thrombophilia (protein S deficiency, homocysteinemia, high Factor VIII). In case #2, on 100mg T gel/day, serum estradiol was high, 51pg/ml (upper normal limit 42.6pg/ml). At least 1.4% of men hospitalized for DVT-PE were on TT and had previously undiagnosed thrombophilia, suggesting a thrombotic interaction between exogenous T and thrombophilia-hypofibrinolysis. Given the increasing use of TT, our preliminary findings should facilitate design of a much-needed, multi-center, prospective study of pro-thrombotic interactions between T therapy and thrombophilia for subsequent thrombotic events including DVT-PE. [B]Written by:[/B] Glueck CJ, Friedman J, Hafeez A, Hassan A, Wang P. [I]Jewish Hospital Cholesterol Center, Jewish Hospital of Cincinnati, United States; Internal Medicine Residency Program, Jewish Hospital of Cincinnati, United States. [EMAIL="cjglueck@health-partners.org"]cjglueck@health-partners.org[/EMAIL][/I] [B]Reference:[/B] Med Hypotheses. 2015 Jan 21. pii: S0306-9877(15)00041-9. [B]doi:[/B] 10.1016/j.mehy.2015.01.020. [/QUOTE]
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Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck
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