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General Health & Fitness
Nutrition and Supplements
Can Oral Glutathione Supplements Work?
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<blockquote data-quote="Jasen Bruce" data-source="post: 8295" data-attributes="member: 14"><p>Glutathione is best administered via injection. It absorbs very poorly when administered orally, only a small fraction would be bio-available. Im not too familiar with the inhalers. Glutathione is very fragile so it must be stored in the fridge and used within the listed shelf-life (usually 90 days with the injectable). </p><p></p><p>Here is another fact sheet for injectable glutathione: <a href="http://defymedical.com/resources/health-articles/162" target="_blank">http://defymedical.com/resources/health-articles/162</a> </p><p></p><p>It can certainly help with alcohol toxicity and "hang-over" symptoms as GSH binds to alcohol converting it to compounds which are easily excreted from the body. This excerpt from Life Extension regarding GSH and alcohol says it best: <strong></strong></p><p><strong>"Glutathione.</strong> Oxidative stress combined with acetaldehyde causes a profound impairment of the body's natural antioxidant systems, by depleting stores of a compound called glutathione (McKillop 2005). Restoring cellular healthy glutathione levels, therefore, seems to be a natural strategy to prevent alcohol-related cancers. </p><p>Glutathione, one of the body's most important natural antioxidants, plays a key role in alcohol detoxification. In the liver, glutathione binds to toxins and transforms them into compounds that can be excreted in the bile or urine. The liver's supply of glutathione may be exhausted by binding to carcinogens produced during alcohol detoxification by the liver. The direct conjugation of acetaldehyde and glutathione has been observed in acute models of alcohol ingestion. When depleted by chronic alcohol ingestion, glutathione becomes unavailable for ordinary regulatory processes.</p><p>These findings should not surprise anyone who understands that the ingestion of alcohol inflicts massive free-radical damage throughout the body. When a person is exposed to a known toxic substance (such as alcohol), it makes sense to take an antidote (antioxidants) to provide at least partial protection against the short-term (hangover) and long-term (degenerative disease) effects." </p><p></p><p>Another good treatment for alcohol toxicity is oral supplementation of N-Acetyl-Cysteine (NAC). NAC is a precursor to glutathione and appears to absorb well orally. In addition, NAC can bind directly to alcohol reducing the effects of alcohol on surrounding tissues.</p><p></p><p>N-acetyl cysteine (NAC) powerfully replenishes glutathione levels in tissues, helping to fend off the consequences of acute oxidative stress (Pascale 1989; Novitskiy 2006). Rats supplemented with NAC prior to treatment with acetaldehyde are potently protected against toxicity and death; the effect is even more powerful when combined with vitamin C and thiamine (Novitskiy 2006). Independently, NAC binds acetaldehyde directly, further preventing its damaging effects (Vasdev 1995).</p><p></p><p>Protocol:</p><p></p><p>Injectable GSH: Take 1000mg-1600mg per week (spread out, for example 2.5cc two to three times per week for 30-90 days (for acute detox). When drinking alcohol, take one dose prior to drinking and another the day after. Try supplementing with 600mg of NAC orally on the same days.</p></blockquote><p></p>
[QUOTE="Jasen Bruce, post: 8295, member: 14"] Glutathione is best administered via injection. It absorbs very poorly when administered orally, only a small fraction would be bio-available. Im not too familiar with the inhalers. Glutathione is very fragile so it must be stored in the fridge and used within the listed shelf-life (usually 90 days with the injectable). Here is another fact sheet for injectable glutathione: [URL]http://defymedical.com/resources/health-articles/162[/URL] It can certainly help with alcohol toxicity and "hang-over" symptoms as GSH binds to alcohol converting it to compounds which are easily excreted from the body. This excerpt from Life Extension regarding GSH and alcohol says it best: [B] "Glutathione.[/B] Oxidative stress combined with acetaldehyde causes a profound impairment of the body's natural antioxidant systems, by depleting stores of a compound called glutathione (McKillop 2005). Restoring cellular healthy glutathione levels, therefore, seems to be a natural strategy to prevent alcohol-related cancers. Glutathione, one of the body's most important natural antioxidants, plays a key role in alcohol detoxification. In the liver, glutathione binds to toxins and transforms them into compounds that can be excreted in the bile or urine. The liver's supply of glutathione may be exhausted by binding to carcinogens produced during alcohol detoxification by the liver. The direct conjugation of acetaldehyde and glutathione has been observed in acute models of alcohol ingestion. When depleted by chronic alcohol ingestion, glutathione becomes unavailable for ordinary regulatory processes. These findings should not surprise anyone who understands that the ingestion of alcohol inflicts massive free-radical damage throughout the body. When a person is exposed to a known toxic substance (such as alcohol), it makes sense to take an antidote (antioxidants) to provide at least partial protection against the short-term (hangover) and long-term (degenerative disease) effects." Another good treatment for alcohol toxicity is oral supplementation of N-Acetyl-Cysteine (NAC). NAC is a precursor to glutathione and appears to absorb well orally. In addition, NAC can bind directly to alcohol reducing the effects of alcohol on surrounding tissues. N-acetyl cysteine (NAC) powerfully replenishes glutathione levels in tissues, helping to fend off the consequences of acute oxidative stress (Pascale 1989; Novitskiy 2006). Rats supplemented with NAC prior to treatment with acetaldehyde are potently protected against toxicity and death; the effect is even more powerful when combined with vitamin C and thiamine (Novitskiy 2006). Independently, NAC binds acetaldehyde directly, further preventing its damaging effects (Vasdev 1995). Protocol: Injectable GSH: Take 1000mg-1600mg per week (spread out, for example 2.5cc two to three times per week for 30-90 days (for acute detox). When drinking alcohol, take one dose prior to drinking and another the day after. Try supplementing with 600mg of NAC orally on the same days. [/QUOTE]
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Can Oral Glutathione Supplements Work?
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