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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!
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<blockquote data-quote="nurselyfe" data-source="post: 90377" data-attributes="member: 16355"><p>Think about this scenario. 20 years old, no health issues prior, jumps on TRT. While on TRT, still no health issues. Great libido, great hair, great erections, great skin, no muscle wastage, recovery is great, mood is incredible, doesn't know what depression or anxiety even is. Used nolvadex and clomid in the past, while taking short breaks, responded well to them. Used arimidex in the past at small doses (0.2mg) every 2 weeks to control estrogen. </p><p></p><p>At 23 years old, while everything was still the same, E2 gets crashed to most likely zero, all of this changes within a few days, and only progressively gets worse. </p><p></p><p>I now am on 100mg a week, no AI, like I've been doing for the last few years, and feel like an alien compared to what I used to feel like. </p><p></p><p>There was even a point where I did 100mg a week and no AI for 3 months (just to improve joint comfort) and had stellar libido, great skin hair and nails, mood etc. </p><p></p><p>I'm on that SAME protocol now and I have none of that. </p><p></p><p>This should tell anyone with common sense something is wrong. What's the first thing someone would look at? Probably thyroid. Thyroid looks good as per endocrinologist, and myself. Adrenals second? Adrenals look good, aldo and cortisol are in range. I don't have fatigue issues or orthostatic hypotension. What's next? Pituitary output of GH? Also in normal range 267 (53-350). I don't know what else could be causing this problem except estrogen insensitivity. I've said it from the start of all of this I had some kind of altered gene expression. But like you, I didn't want to believe something so bizzare and not backed by any kind of literature on the internet. After awhile, I found PFS sites and saw that a subset of these men definitely had some kind of proposed androgen insensitivity that cannot be cured by T, Clomid, HCG. It exists. </p><p></p><p>Another thought. Think about the first person to present with fibromyalgia. Body aches and muscle pains all over. Doctors probably thought they were crazy at first. But after research, it clearly exists and is now diagnosable and partially treatable. What I am saying is, consider the possibility that we have not discovered everything about the human body yet. The anecdotal evidence is there, people getting <u>persistent</u> side effects from all kinds of inhibitors; Accutane, Finasteride, SSRI's, and now look, Arimidex. It just needs to be studied further on a molecular level to prove it. And if it is looked into on the molecular, post transcription level, and nothing comes back abnormal, I will stand down. </p><p></p><p>To answer your questions on the severity of my ED. Before, I had extremely hard erections that I could get just by thinking about something. I never had ED from drinking even which my girlfriend loved. It would get throbbing, veiny, and red full of blood. </p><p></p><p>Now, they're about 60-70% as hard and I lose the erection extremely quickly. I can get hard by viewing pornography but it's only 60-70% hard. Same thing when I have sex with my girlfriend. I just don't get hammers anymore and my libido is almost zero. </p><p></p><p>I don't know what Dr. Saya would do for me. My protocol is good. 29mg T EOD IM, no AI, and no hcg since I do not respond to it.</p></blockquote><p></p>
[QUOTE="nurselyfe, post: 90377, member: 16355"] Think about this scenario. 20 years old, no health issues prior, jumps on TRT. While on TRT, still no health issues. Great libido, great hair, great erections, great skin, no muscle wastage, recovery is great, mood is incredible, doesn't know what depression or anxiety even is. Used nolvadex and clomid in the past, while taking short breaks, responded well to them. Used arimidex in the past at small doses (0.2mg) every 2 weeks to control estrogen. At 23 years old, while everything was still the same, E2 gets crashed to most likely zero, all of this changes within a few days, and only progressively gets worse. I now am on 100mg a week, no AI, like I've been doing for the last few years, and feel like an alien compared to what I used to feel like. There was even a point where I did 100mg a week and no AI for 3 months (just to improve joint comfort) and had stellar libido, great skin hair and nails, mood etc. I'm on that SAME protocol now and I have none of that. This should tell anyone with common sense something is wrong. What's the first thing someone would look at? Probably thyroid. Thyroid looks good as per endocrinologist, and myself. Adrenals second? Adrenals look good, aldo and cortisol are in range. I don't have fatigue issues or orthostatic hypotension. What's next? Pituitary output of GH? Also in normal range 267 (53-350). I don't know what else could be causing this problem except estrogen insensitivity. I've said it from the start of all of this I had some kind of altered gene expression. But like you, I didn't want to believe something so bizzare and not backed by any kind of literature on the internet. After awhile, I found PFS sites and saw that a subset of these men definitely had some kind of proposed androgen insensitivity that cannot be cured by T, Clomid, HCG. It exists. Another thought. Think about the first person to present with fibromyalgia. Body aches and muscle pains all over. Doctors probably thought they were crazy at first. But after research, it clearly exists and is now diagnosable and partially treatable. What I am saying is, consider the possibility that we have not discovered everything about the human body yet. The anecdotal evidence is there, people getting [U]persistent[/U] side effects from all kinds of inhibitors; Accutane, Finasteride, SSRI's, and now look, Arimidex. It just needs to be studied further on a molecular level to prove it. And if it is looked into on the molecular, post transcription level, and nothing comes back abnormal, I will stand down. To answer your questions on the severity of my ED. Before, I had extremely hard erections that I could get just by thinking about something. I never had ED from drinking even which my girlfriend loved. It would get throbbing, veiny, and red full of blood. Now, they're about 60-70% as hard and I lose the erection extremely quickly. I can get hard by viewing pornography but it's only 60-70% hard. Same thing when I have sex with my girlfriend. I just don't get hammers anymore and my libido is almost zero. I don't know what Dr. Saya would do for me. My protocol is good. 29mg T EOD IM, no AI, and no hcg since I do not respond to it. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!
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