I just want to chime in on the mind is a powerful thing part of this conversation.
When I first began TRT with my current provider, I was given Anastozole .22mg to be taken twice a week. I had already read on the usage of AI's and how one needs to be careful to not crash their E2. Having been at a previous protocol of 50mg Test C every 3.5 days (E2 was 40.5 @ this protocol), I was also increased to 70mg Test twice a week to go along with the AI. For 3 weeks or so I felt fine, then I slowly began to deteriorate, fatigue increased, depression got stronger as well. I started reading more on the AI and its side effects, soon I was experiencing joint pain, frequent urination, dry flaky skin, anxiety as well as depression, a few more things as well. I was convinced I had crashed my E2! My provider sent me in for lab work, and I instantly stopped the AI after that. Within 2 days I was feeling better, depression was clearing, joint pain was gone, anxiety was far less than the previous days. I had crashed my E2, things are great now, I will not need a AI while on TRT. A few days go went by and I got a phone call, my E2 was 58 on the sensitive test! I was told to go back onto the AI, and add a 3rd dose per week. I took my treatment out of my hands that day and gave it to my provider. I got off the TRT forums for a while, as recommended by my provider (Melissa @ Defy). Doing this cleared my mind of all the things that could go wrong, and left me to deal with me, not what I was reading. The AI 3 times a week got my E2 done to 30 and I feel fine, no high or low symptoms to speak of any more. In short, my mind had convinced me that I was crashed, and even developed symptoms of a crash.
