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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!
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<blockquote data-quote="zancek0" data-source="post: 260727" data-attributes="member: 45189"><p>I would try to avoid tren. It binds to both progesterone and glucocorticoid receptors, likely upregulating AR (androgen receptors) via weaker glucocorticoid receptor binding (AR and GR are in tight interaction) and downregulating ER via progesterone activity. Proviron also upregulates 5AR due to being weaker than pure DHT and binding to AR. I'm not sure about aromasin - it doesnt lead to rebound effect so idk what happens to ER expression...</p><p></p><p>I'm actually in a similar boat. Crashed E2 with aromasin while natty and havent recovered. That was 5 months ago. Started TRT 2 months ago - 20mg eod (70mg/week) and slightly improved in some aspects but anxiety worsened. On blood tests this amount of test brought my levels to 2000. So I dropped the dose to 8mg ED and added inj. e2 enanthate 0.1mg ED (had a custom vial made - 5mg/ml). Weirdly enough, I don't seem to benefit much from this. Every scent is magnified 10x for some reason, haha. But I don't feel much better. The dose is very low and I've just started this about 2 weeks ago. However, I've also just started a new summer job and I really need to be functional which right now I am barely. I seem to have aggravated some issues post vaccine with this E2 crash...</p><p>So why am I not feeling that good on exo E2? It could be because low test dose preferentially converts to DHT, doubly so to oppose elevated E2 levels by exo E2. AR regulate themselves partly also in response to ER and estrogens. So if you have high E2 levels AR will upregulate. But now with me doing very low doses of test that possibly convert to DHT more than to E2 and also adding exo e2 I'm likely just upregulating AR and 5AR and downregulating ER. I don't know yet.</p><p>It's a puzzle. But I think that your issues might also involve electrolyte and mineral imbalance, possibly even infections.</p><p></p><p>Dont add DHEA or prog to your protocol. You could probably decrease test dose and increase potassium intake which you're likely deficient in. Dont take pills with progestins. Just basic oral e2. Right now I can't offer much guidance since I havent yet recovered.</p><p></p><p>Btw, do you have any extensive labs to share?</p></blockquote><p></p>
[QUOTE="zancek0, post: 260727, member: 45189"] I would try to avoid tren. It binds to both progesterone and glucocorticoid receptors, likely upregulating AR (androgen receptors) via weaker glucocorticoid receptor binding (AR and GR are in tight interaction) and downregulating ER via progesterone activity. Proviron also upregulates 5AR due to being weaker than pure DHT and binding to AR. I'm not sure about aromasin - it doesnt lead to rebound effect so idk what happens to ER expression... I'm actually in a similar boat. Crashed E2 with aromasin while natty and havent recovered. That was 5 months ago. Started TRT 2 months ago - 20mg eod (70mg/week) and slightly improved in some aspects but anxiety worsened. On blood tests this amount of test brought my levels to 2000. So I dropped the dose to 8mg ED and added inj. e2 enanthate 0.1mg ED (had a custom vial made - 5mg/ml). Weirdly enough, I don't seem to benefit much from this. Every scent is magnified 10x for some reason, haha. But I don't feel much better. The dose is very low and I've just started this about 2 weeks ago. However, I've also just started a new summer job and I really need to be functional which right now I am barely. I seem to have aggravated some issues post vaccine with this E2 crash... So why am I not feeling that good on exo E2? It could be because low test dose preferentially converts to DHT, doubly so to oppose elevated E2 levels by exo E2. AR regulate themselves partly also in response to ER and estrogens. So if you have high E2 levels AR will upregulate. But now with me doing very low doses of test that possibly convert to DHT more than to E2 and also adding exo e2 I'm likely just upregulating AR and 5AR and downregulating ER. I don't know yet. It's a puzzle. But I think that your issues might also involve electrolyte and mineral imbalance, possibly even infections. Dont add DHEA or prog to your protocol. You could probably decrease test dose and increase potassium intake which you're likely deficient in. Dont take pills with progestins. Just basic oral e2. Right now I can't offer much guidance since I havent yet recovered. Btw, do you have any extensive labs to share? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!
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