Interesting. It sounds like in ur case that it was more a matter of fixing ur test to estrogen ratio, more so than simply getting more estrogen in ur system. Crashing ur E2 may have possibly altered ur estrogen conversion rate, from the sounds of it. Do u think there’s a chance that using exogenous E2 has reverted ur estrogen conversion rate back to converting at a higher rate, similar to before u crashed ur E2?

Another thing to consider is that E2 in a blood test doesn’t reflect how much is in ur brain, or other parts of the body. It’s simply testing the spill over that’s currently in ur blood. So it’s not as simple as saying “my blood test shows E2 in range, therefore it doesn’t make sense that I’m experiencing low or high E2 symptoms in specific areas” Like mental effects, sexual effects, and/ or effects in my joints. There could be much different levels of estrogen in certain parts of the body, dependent on what ur seeing in spill over in a blood test. Then there’s also the issue of receptor sensitivity. The same amount of estrogen in a person‘s system can result in different effects based on how sensitive, or not sensitive, their estrogen receptors are to the estrogen that attaches to that specific receptor site on the cell

and I guess in theory is could make sense that Wellbutrin helped that person. Estrogen does play a big role in neurotransmitter production. So if a person has an issue with producing enough estrogen endogenously, and consequently possibly not making enough endogenous dopamine, I can see how Wellbutrin could make them feel better