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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!
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<blockquote data-quote="JustPanicNoDisco" data-source="post: 217015" data-attributes="member: 42100"><p>Are you still on TRT and running the same protocol? </p><p></p><p>I'd enjoy talking theory, if you're interested, as I'm in the same boat and you seem quite knowledgeable about medicine. </p><p></p><p>I'm at a crossroads, where I have no idea whether I should stay on TRT or risk attempting a PCT protocol. I'm very sensitive to hormonal fluctuations, especially from substances that inhibit aromatase, like Cialis, so I imagine antagonizing estrogen both centrally and peripherally with clomiphene or tamoxifen could end extremely poorly. That said, anecdotally, it appears people's bodies are less likely to find homeostasis again when running exogenous hormones. </p><p></p><p>I, too, believe that there are epigenetic changes that have occurred. Methylation is an active process, though -- a process very necessary to human life. I don't know why we'd get "stuck" with gene silencing; it "should" reverse eventually as the body "recognizes" low e2 symptoms in the presence of adequate amounts of the ligand. </p><p></p><p>Is it possible exogenous hormones delay / prevent demethylation processes from occurring? Normally, the HPTA governs hormonal production, and perhaps by dictating our body's hormone levels, the body is not able to adjust its levels accordingly in order to correct the receptor expression issues.</p></blockquote><p></p>
[QUOTE="JustPanicNoDisco, post: 217015, member: 42100"] Are you still on TRT and running the same protocol? I'd enjoy talking theory, if you're interested, as I'm in the same boat and you seem quite knowledgeable about medicine. I'm at a crossroads, where I have no idea whether I should stay on TRT or risk attempting a PCT protocol. I'm very sensitive to hormonal fluctuations, especially from substances that inhibit aromatase, like Cialis, so I imagine antagonizing estrogen both centrally and peripherally with clomiphene or tamoxifen could end extremely poorly. That said, anecdotally, it appears people's bodies are less likely to find homeostasis again when running exogenous hormones. I, too, believe that there are epigenetic changes that have occurred. Methylation is an active process, though -- a process very necessary to human life. I don't know why we'd get "stuck" with gene silencing; it "should" reverse eventually as the body "recognizes" low e2 symptoms in the presence of adequate amounts of the ligand. Is it possible exogenous hormones delay / prevent demethylation processes from occurring? Normally, the HPTA governs hormonal production, and perhaps by dictating our body's hormone levels, the body is not able to adjust its levels accordingly in order to correct the receptor expression issues. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!
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