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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!
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<blockquote data-quote="simeoni" data-source="post: 120348" data-attributes="member: 14463"><p>Look. After several crashes the main symptom for me was apathy and other things related to dopamine - loss of libido, ability to feel pleasure, lack of drive etc. </p><p></p><p>This happened to me in the past when I had crashed my E2. To only difference was that these symptoms would eventually disappear when my estrogen rose back to normal levels. For some reason at the end of 2016 these symptoms did not resolve - even though my estrogen levels were in the normal range. </p><p></p><p>In my understanding its very clear in the literature that estrogen plays an protective role regarding the neurons that are supposed to release dopamine. There was also the animal study that showed how a prolonged deprivation of estrogen lead to a loss of certain amount of dopaminergic neurons - in the substantia nigra.</p><p></p><p>There are of course no human studies on this and the ones done in animals cannot be taken as evidence for the same effect in humans. Still all those studies have some weight for me and in the light of them I do not see the possibility of dopaminergic damage as an "odd theory". </p><p></p><p>On a different note. I would say that my condition has somewhat improved. Especially if you look how I was a year ago. I have also been doing pretty thorough testing and found out that I have few deficiencies that I need to fix. I will give an update on all that at some point.</p></blockquote><p></p>
[QUOTE="simeoni, post: 120348, member: 14463"] Look. After several crashes the main symptom for me was apathy and other things related to dopamine - loss of libido, ability to feel pleasure, lack of drive etc. This happened to me in the past when I had crashed my E2. To only difference was that these symptoms would eventually disappear when my estrogen rose back to normal levels. For some reason at the end of 2016 these symptoms did not resolve - even though my estrogen levels were in the normal range. In my understanding its very clear in the literature that estrogen plays an protective role regarding the neurons that are supposed to release dopamine. There was also the animal study that showed how a prolonged deprivation of estrogen lead to a loss of certain amount of dopaminergic neurons - in the substantia nigra. There are of course no human studies on this and the ones done in animals cannot be taken as evidence for the same effect in humans. Still all those studies have some weight for me and in the light of them I do not see the possibility of dopaminergic damage as an "odd theory". On a different note. I would say that my condition has somewhat improved. Especially if you look how I was a year ago. I have also been doing pretty thorough testing and found out that I have few deficiencies that I need to fix. I will give an update on all that at some point. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!
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