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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!
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<blockquote data-quote="HereForTheE2" data-source="post: 118758" data-attributes="member: 19489"><p>Hey there, i've been reading up on this forum for a couple days now after I experienced what seemed like my second estrogen crash coming off of my first cycle.</p><p>My first and ONLY cycle was as follows:</p><p>24 years old</p><p>300-325 mg of test cypionate two injections per week mon/thur.</p><p>And throughout the entire cycle i had aromasin on hand for sides.</p><p></p><p>About 1 month into my cycle i noticed that my nipples were getting a bit sensitive so I started taking aromasin 12.5 mg eod as advised by some forums. I noticed that my nipple sensitivity went away about about 10 days but that i was also getting lightheaded in the gym and noticed that the skin on my hands were getting dry.</p><p>I discontinued the aromasin after this for the remainder of the cycle. End of my cycle hits, at which point I decided to come off cold turkey with no PCT. For the first week or so off of my cycle I took aromasin sparingly and eventually discontinued its use entirely.</p><p>June 24th is the estimated date that I presume my esters have completely cleared. And I noticed what seemed like my first estrogen around June 1st-12th. I expected some post cycle anxiety, depression etc at this point and meditated my way through it and eventually everything went back to normal. SIDE NOTED: I was diagnosed with ADHD and was taking ritalin as prescribed during the withdrawal from the cypionate.</p><p>It seems I made a full HPA recovery around June 14th with a full return of my testicles, cognitive function and depressive symptoms being absent. </p><p>Fast forward to July27th. On the 27th of July i had been smoking cannabis and I noticed that i had an intense panic attack and have had residual effects since. What is strange is that all of my skins sebum production has ceased and my acne is non existent(I have always been prone to acne and large sebum production so the sudden cessation has me worried).</p><p>I have now been experiencing all of the symptoms of low e2:</p><p>Fatigue</p><p>Frequent urination</p><p>COMPLETE ABSENCE OF APPETITE</p><p>Depression</p><p>Anxiety</p><p>Heart Palpitations</p><p>Low blood pressure</p><p>Cracking joints</p><p>lightheaded, dizzyness</p><p>Headaches</p><p>Dry Skin</p><p>Dry Eyes</p><p>Blah, blah blah.</p><p></p><p>I read up on the dopamine damage that may be done by the deprivation of estrogen and promptly ordered estradiol cream intended for menopausal women. After experiencing all of the intense symptoms of low e2 for approximately 10 days, I applied the cream and noticed strange symptoms.</p><p>Upon applying the cream and waiting for the effects to take place i started having strange bouts of abrupt panic coupled with hot flashes. I experienced an intense muscle lock-like symptom where i felt incredibly tense and anxious for approximately 10 minutes with an immediate clarity of mind immediately afterward for the rest of the night. </p><p>I took a day take off of the estradiol cream as I thought that I might have reverted my HPA axis to normal function but some symptoms have begun to come back. I decided that I will be doing the cream for some time in an effort to save my brain and i have read small amounts of estrogen will not shut down the HPA axis. I also noticed that taking DHEA alleviated my symptoms but not completely and have decided that I was do a 6 week round of DHEA.</p><p>I have since learned that the HPA axis is a very complicated neurological system in which endocannabinoids are involved. Endocannabinoids are also present in cannabis which is why my HPA axis may have faultered shortly after smoking the Ganj. Its possible that my HPA axis was in a fragile state and was abruptly disrupted with the introduction of exogenous endocannabinoids.</p><p>Regardless, in the event that i have been in estrogen deprivation and my dopamine neurons are degenerating I will continue to apply the estradiol cream in hopes to recover any sort of neurological catastrophe for the same 6 weeks that I will be on the DHEA.</p><p>Im glad im not the only one experiencing these symptoms and I plan to keep you all posted on my progress.</p><p>I have since decided that I will not continue with anabolics of any sort until i get my mentality back. I have also noticed that I look super lean (Way more lean than is natural for me) and my libido is decent and can function when called upon.</p><p></p><p>*In the event my body is trying to activate these sensitization genes you guys speak of, I will continue to apply the estradiol in an attempt to revert anysort of genetic changes they may have occured.</p><p>Also I noticed my symptoms tend to diminish toward the end of the day allowing me to fall asleep.</p></blockquote><p></p>
[QUOTE="HereForTheE2, post: 118758, member: 19489"] Hey there, i've been reading up on this forum for a couple days now after I experienced what seemed like my second estrogen crash coming off of my first cycle. My first and ONLY cycle was as follows: 24 years old 300-325 mg of test cypionate two injections per week mon/thur. And throughout the entire cycle i had aromasin on hand for sides. About 1 month into my cycle i noticed that my nipples were getting a bit sensitive so I started taking aromasin 12.5 mg eod as advised by some forums. I noticed that my nipple sensitivity went away about about 10 days but that i was also getting lightheaded in the gym and noticed that the skin on my hands were getting dry. I discontinued the aromasin after this for the remainder of the cycle. End of my cycle hits, at which point I decided to come off cold turkey with no PCT. For the first week or so off of my cycle I took aromasin sparingly and eventually discontinued its use entirely. June 24th is the estimated date that I presume my esters have completely cleared. And I noticed what seemed like my first estrogen around June 1st-12th. I expected some post cycle anxiety, depression etc at this point and meditated my way through it and eventually everything went back to normal. SIDE NOTED: I was diagnosed with ADHD and was taking ritalin as prescribed during the withdrawal from the cypionate. It seems I made a full HPA recovery around June 14th with a full return of my testicles, cognitive function and depressive symptoms being absent. Fast forward to July27th. On the 27th of July i had been smoking cannabis and I noticed that i had an intense panic attack and have had residual effects since. What is strange is that all of my skins sebum production has ceased and my acne is non existent(I have always been prone to acne and large sebum production so the sudden cessation has me worried). I have now been experiencing all of the symptoms of low e2: Fatigue Frequent urination COMPLETE ABSENCE OF APPETITE Depression Anxiety Heart Palpitations Low blood pressure Cracking joints lightheaded, dizzyness Headaches Dry Skin Dry Eyes Blah, blah blah. I read up on the dopamine damage that may be done by the deprivation of estrogen and promptly ordered estradiol cream intended for menopausal women. After experiencing all of the intense symptoms of low e2 for approximately 10 days, I applied the cream and noticed strange symptoms. Upon applying the cream and waiting for the effects to take place i started having strange bouts of abrupt panic coupled with hot flashes. I experienced an intense muscle lock-like symptom where i felt incredibly tense and anxious for approximately 10 minutes with an immediate clarity of mind immediately afterward for the rest of the night. I took a day take off of the estradiol cream as I thought that I might have reverted my HPA axis to normal function but some symptoms have begun to come back. I decided that I will be doing the cream for some time in an effort to save my brain and i have read small amounts of estrogen will not shut down the HPA axis. I also noticed that taking DHEA alleviated my symptoms but not completely and have decided that I was do a 6 week round of DHEA. I have since learned that the HPA axis is a very complicated neurological system in which endocannabinoids are involved. Endocannabinoids are also present in cannabis which is why my HPA axis may have faultered shortly after smoking the Ganj. Its possible that my HPA axis was in a fragile state and was abruptly disrupted with the introduction of exogenous endocannabinoids. Regardless, in the event that i have been in estrogen deprivation and my dopamine neurons are degenerating I will continue to apply the estradiol cream in hopes to recover any sort of neurological catastrophe for the same 6 weeks that I will be on the DHEA. Im glad im not the only one experiencing these symptoms and I plan to keep you all posted on my progress. I have since decided that I will not continue with anabolics of any sort until i get my mentality back. I have also noticed that I look super lean (Way more lean than is natural for me) and my libido is decent and can function when called upon. *In the event my body is trying to activate these sensitization genes you guys speak of, I will continue to apply the estradiol in an attempt to revert anysort of genetic changes they may have occured. Also I noticed my symptoms tend to diminish toward the end of the day allowing me to fall asleep. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!
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