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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!
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<blockquote data-quote="nurselyfe" data-source="post: 114645" data-attributes="member: 16355"><p>This would fit my theory of what is taking place on a molecular level here. What you just explained is what initially happened to me.</p><p></p><p>Ive crashed my e2 many times before, but never have I ever experienced these sides and always felt fine after a few days. However, every time I crashed, it felt as if I would become more sensitive to E2. The same blood levels of E2 and not changing my protocol would cause more high symptoms. </p><p></p><p>Then last May when this all began, I was using massive doses of arimidex to get a therapeutic effect. One day I used 1.5mg and my symptoms immediately appeared and have only got worse since despite not using any arimidex and perfect blood levels. </p><p></p><p>I believe an initial over expression of Estrogen receptors due to deprivation is what causes the over sensitivity. Then further deprivation may induce negative autoregulation causing receptor shut down, in laymans terms.</p></blockquote><p></p>
[QUOTE="nurselyfe, post: 114645, member: 16355"] This would fit my theory of what is taking place on a molecular level here. What you just explained is what initially happened to me. Ive crashed my e2 many times before, but never have I ever experienced these sides and always felt fine after a few days. However, every time I crashed, it felt as if I would become more sensitive to E2. The same blood levels of E2 and not changing my protocol would cause more high symptoms. Then last May when this all began, I was using massive doses of arimidex to get a therapeutic effect. One day I used 1.5mg and my symptoms immediately appeared and have only got worse since despite not using any arimidex and perfect blood levels. I believe an initial over expression of Estrogen receptors due to deprivation is what causes the over sensitivity. Then further deprivation may induce negative autoregulation causing receptor shut down, in laymans terms. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!
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