ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
General Health & Fitness
Health & Wellness
Can atherogenic indices and the triglyceride-glucose index be used to predict erectile dysfunction?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="ajax31" data-source="post: 274203" data-attributes="member: 39208"><p><h3>Can atherogenic indices and the triglyceride-glucose index be used to predict erectile dysfunction?</h3><p><a href="https://pubmed.ncbi.nlm.nih.gov/?term=Sambel+M&cauthor_id=38250336" target="_blank">Murat Sambel</a> <a href="https://pubmed.ncbi.nlm.nih.gov/38250336/#full-view-affiliation-1" target="_blank">1</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Erdogan+A&cauthor_id=38250336" target="_blank">Abdullah Erdogan</a> <a href="https://pubmed.ncbi.nlm.nih.gov/38250336/#full-view-affiliation-2" target="_blank">2</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Caglayan+V&cauthor_id=38250336" target="_blank">Volkan Caglayan</a> <a href="https://pubmed.ncbi.nlm.nih.gov/38250336/#full-view-affiliation-2" target="_blank">2</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Avci+S&cauthor_id=38250336" target="_blank">Sinan Avci</a> <a href="https://pubmed.ncbi.nlm.nih.gov/38250336/#full-view-affiliation-2" target="_blank">2</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Kilic+S&cauthor_id=38250336" target="_blank">Sahin Kilic</a> <a href="https://pubmed.ncbi.nlm.nih.gov/38250336/#full-view-affiliation-1" target="_blank">1</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Yildiz+HE&cauthor_id=38250336" target="_blank">Halil Emre Yildiz</a> <a href="https://pubmed.ncbi.nlm.nih.gov/38250336/#full-view-affiliation-3" target="_blank">3</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Keskin+E&cauthor_id=38250336" target="_blank">Ercument Keskin</a> <a href="https://pubmed.ncbi.nlm.nih.gov/38250336/#full-view-affiliation-4" target="_blank">4</a></p><p>Affiliations expand</p><ul> <li data-xf-list-type="ul">PMID: <strong>38250336</strong></li> <li data-xf-list-type="ul">PMCID: <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10799712/" target="_blank">PMC10799712</a></li> <li data-xf-list-type="ul">DOI: <a href="https://doi.org/10.1093/sexmed/qfad069" target="_blank">10.1093/sexmed/qfad069</a></li> </ul><h3>Abstract</h3><p><strong>Background: </strong>Atherosclerosis and insulin resistance play an important role in the development of erectile dysfunction (ED), and few studies have comprehensively evaluated more specific indicators like atherogenic indices and the triglyceride-glucose (TyG) index in the assessment of ED.</p><p><strong>Aim: </strong>This study aimed to reveal the role of atherogenic indices (atherogenic index of plasma [AIP], Castelli risk index-1/2 [CRI-1/2], and atherogenic coefficient [AC]) based on plasma lipid ratios, which have been used as more sensitive indicators of atherosclerosis in recent years, and the TyG index, a practical indicator of insulin resistance, in predicting vasculogenic ED.</p><p><strong>Methods: </strong>The study included a total of 199 patients who met the inclusion criteria and a total of 51 control subjects without ED complaints according to the International Index of Erectile Function (IIEF-5) scores (>21) between May 2021 and October 2022. For all participants, the demographic and biochemical parameters were evaluated, and atherogenic indices, namely CRI-1 (total cholesterol/high-density lipoprotein [HDL]), CRI-2 (LDL/HDL) AIP [log10(triglycerides/HDL)], and AC (non-HDL/HDL), as well as the TyG index [Ln {fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2}] were calculated.</p><p><strong>Outcomes: </strong>The TyG index, which is an indicator of insulin resistance, and atherogenic indices such as CRI-1, AIP, and AC were significantly associated with ED, and especially AIP and the TyG index seem to be more important in the evaluation of ED.</p><p><strong>Results: </strong>According to the univariate analysis, the patient group had significantly higher CRI-1 (5.3 ± 1.4 vs 4.7 ± 1.3; <em>P</em> = .005), AIP (0.31 ± 0.26 vs 0.13 ± 0.2; <em>P</em> < .001), AC (4.1 ± 1.4 vs 3.70 ± 1.2; <em>P</em> = .026), and TyG (9.16 ± 0.71 vs 8.77 ± 0.52; <em>P</em> < .001) values compared with the control group. In the correlation analysis, a significant negative correlation was found between the AIP and TyG index and the IIEF-5 scores (r2 = 0.120, <em>P</em> < .001 between AIP and IIEF-5; r2 = 0.091, <em>P</em> < .001 between TyG index and IIEF-5). The multivariate analysis revealed AIP and the TyG index as independent predictive factors for ED.</p><p><strong>Clinical implications: </strong>The use of atherogenic indices and TyG index in daily urology practice can help physicians in the diagnosis and follow-up of ED.</p><p><strong>Strengths and limitations: </strong>The lack of sex hormone-binding globulin and free testosterone levels represents a limitation of our study. Another limitation is that the severity of ED was determined using the IIEF-5 scores, rather than a more objective method, such as penile artery ultrasound.</p><p><strong>Conclusion: </strong>Atherogenic indices and the TyG index can be used as inexpensive and practical markers to predict the severity of arteriogenic ED.</p><p><strong>Keywords: </strong>atherogenic indices; endothelial dysfunction; erectile dysfunction; insulin resistance; triglyceride-glucose index.</p><p>© The Author(s) 2024. Published by Oxford University Press on behalf of The International Society of Sexual Medicine.</p><p></p><p>[URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/38250336/[/URL]</p></blockquote><p></p>
[QUOTE="ajax31, post: 274203, member: 39208"] [HEADING=2]Can atherogenic indices and the triglyceride-glucose index be used to predict erectile dysfunction?[/HEADING] [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Sambel+M&cauthor_id=38250336']Murat Sambel[/URL] [URL='https://pubmed.ncbi.nlm.nih.gov/38250336/#full-view-affiliation-1']1[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Erdogan+A&cauthor_id=38250336']Abdullah Erdogan[/URL] [URL='https://pubmed.ncbi.nlm.nih.gov/38250336/#full-view-affiliation-2']2[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Caglayan+V&cauthor_id=38250336']Volkan Caglayan[/URL] [URL='https://pubmed.ncbi.nlm.nih.gov/38250336/#full-view-affiliation-2']2[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Avci+S&cauthor_id=38250336']Sinan Avci[/URL] [URL='https://pubmed.ncbi.nlm.nih.gov/38250336/#full-view-affiliation-2']2[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Kilic+S&cauthor_id=38250336']Sahin Kilic[/URL] [URL='https://pubmed.ncbi.nlm.nih.gov/38250336/#full-view-affiliation-1']1[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Yildiz+HE&cauthor_id=38250336']Halil Emre Yildiz[/URL] [URL='https://pubmed.ncbi.nlm.nih.gov/38250336/#full-view-affiliation-3']3[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Keskin+E&cauthor_id=38250336']Ercument Keskin[/URL] [URL='https://pubmed.ncbi.nlm.nih.gov/38250336/#full-view-affiliation-4']4[/URL] Affiliations expand [LIST] [*]PMID: [B]38250336[/B] [*]PMCID: [URL='http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10799712/']PMC10799712[/URL] [*]DOI: [URL='https://doi.org/10.1093/sexmed/qfad069']10.1093/sexmed/qfad069[/URL] [/LIST] [HEADING=2]Abstract[/HEADING] [B]Background: [/B]Atherosclerosis and insulin resistance play an important role in the development of erectile dysfunction (ED), and few studies have comprehensively evaluated more specific indicators like atherogenic indices and the triglyceride-glucose (TyG) index in the assessment of ED. [B]Aim: [/B]This study aimed to reveal the role of atherogenic indices (atherogenic index of plasma [AIP], Castelli risk index-1/2 [CRI-1/2], and atherogenic coefficient [AC]) based on plasma lipid ratios, which have been used as more sensitive indicators of atherosclerosis in recent years, and the TyG index, a practical indicator of insulin resistance, in predicting vasculogenic ED. [B]Methods: [/B]The study included a total of 199 patients who met the inclusion criteria and a total of 51 control subjects without ED complaints according to the International Index of Erectile Function (IIEF-5) scores (>21) between May 2021 and October 2022. For all participants, the demographic and biochemical parameters were evaluated, and atherogenic indices, namely CRI-1 (total cholesterol/high-density lipoprotein [HDL]), CRI-2 (LDL/HDL) AIP [log10(triglycerides/HDL)], and AC (non-HDL/HDL), as well as the TyG index [Ln {fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2}] were calculated. [B]Outcomes: [/B]The TyG index, which is an indicator of insulin resistance, and atherogenic indices such as CRI-1, AIP, and AC were significantly associated with ED, and especially AIP and the TyG index seem to be more important in the evaluation of ED. [B]Results: [/B]According to the univariate analysis, the patient group had significantly higher CRI-1 (5.3 ± 1.4 vs 4.7 ± 1.3; [I]P[/I] = .005), AIP (0.31 ± 0.26 vs 0.13 ± 0.2; [I]P[/I] < .001), AC (4.1 ± 1.4 vs 3.70 ± 1.2; [I]P[/I] = .026), and TyG (9.16 ± 0.71 vs 8.77 ± 0.52; [I]P[/I] < .001) values compared with the control group. In the correlation analysis, a significant negative correlation was found between the AIP and TyG index and the IIEF-5 scores (r2 = 0.120, [I]P[/I] < .001 between AIP and IIEF-5; r2 = 0.091, [I]P[/I] < .001 between TyG index and IIEF-5). The multivariate analysis revealed AIP and the TyG index as independent predictive factors for ED. [B]Clinical implications: [/B]The use of atherogenic indices and TyG index in daily urology practice can help physicians in the diagnosis and follow-up of ED. [B]Strengths and limitations: [/B]The lack of sex hormone-binding globulin and free testosterone levels represents a limitation of our study. Another limitation is that the severity of ED was determined using the IIEF-5 scores, rather than a more objective method, such as penile artery ultrasound. [B]Conclusion: [/B]Atherogenic indices and the TyG index can be used as inexpensive and practical markers to predict the severity of arteriogenic ED. [B]Keywords: [/B]atherogenic indices; endothelial dysfunction; erectile dysfunction; insulin resistance; triglyceride-glucose index. © The Author(s) 2024. Published by Oxford University Press on behalf of The International Society of Sexual Medicine. [URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/38250336/[/URL] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
General Health & Fitness
Health & Wellness
Can atherogenic indices and the triglyceride-glucose index be used to predict erectile dysfunction?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top