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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Can anyone solve my Testosterone puzzle
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<blockquote data-quote="Cataceous" data-source="post: 237880" data-attributes="member: 38109"><p>Are there any sexual symptoms when you feel hypogonadal? Unfortunately TRT is still far from being an exact science, and there's a lot of trial and error involved. One possibility that somewhat fits your description is an imbalance in favor of estrogenicity. DHT opposes estrogen in various ways, potentially explaining why you do better with topical testosterone. Estrogens tend to increase prolactin, and yours is elevated.</p><p></p><p>There are various treatments you can trial to see if they help. My first option would be to try daily injections of a blend of testosterone propionate and a longer ester such as cypionate. I'd also start with a mid-range dose such that daily testosterone intake is 6-7 mg. This would be 8-10 mg of the testosterone esters. If there's not improvement after trying various doses with enough stabilization time in between then I would try adding in occasional use of topical testosterone applied to the scrotum. Some guys find that infrequent DHT boosts make an injection protocol viable. You mention feeling good on weekly injections when serum testosterone is rising. The advantage of injecting a blend daily is that you experience rising testosterone daily, which is more in line with what's natural.</p><p></p><p>Other treatment options that might make an injection protocol tolerable are aromatase inhibitors, SERMs or cabergoline. I would not mess with an AI unless there's stronger evidence implicating estrogenicity. The same might be said for SERMs, but a trial with enclomiphene could be relatively safe because there's no risk of crashing estradiol. Cabergoline would attack the elevated prolactin in isolation. However, you haven't mentioned the typical symptoms seen with higher prolactin.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 237880, member: 38109"] Are there any sexual symptoms when you feel hypogonadal? Unfortunately TRT is still far from being an exact science, and there's a lot of trial and error involved. One possibility that somewhat fits your description is an imbalance in favor of estrogenicity. DHT opposes estrogen in various ways, potentially explaining why you do better with topical testosterone. Estrogens tend to increase prolactin, and yours is elevated. There are various treatments you can trial to see if they help. My first option would be to try daily injections of a blend of testosterone propionate and a longer ester such as cypionate. I'd also start with a mid-range dose such that daily testosterone intake is 6-7 mg. This would be 8-10 mg of the testosterone esters. If there's not improvement after trying various doses with enough stabilization time in between then I would try adding in occasional use of topical testosterone applied to the scrotum. Some guys find that infrequent DHT boosts make an injection protocol viable. You mention feeling good on weekly injections when serum testosterone is rising. The advantage of injecting a blend daily is that you experience rising testosterone daily, which is more in line with what's natural. Other treatment options that might make an injection protocol tolerable are aromatase inhibitors, SERMs or cabergoline. I would not mess with an AI unless there's stronger evidence implicating estrogenicity. The same might be said for SERMs, but a trial with enclomiphene could be relatively safe because there's no risk of crashing estradiol. Cabergoline would attack the elevated prolactin in isolation. However, you haven't mentioned the typical symptoms seen with higher prolactin. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Can anyone solve my Testosterone puzzle
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