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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Calling All Long-Term TRT Users! How is Your Libido and Sexual Function?
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<blockquote data-quote="madman" data-source="post: 204984" data-attributes="member: 13851"><p>Unfortunately, everyone is so caught up on higher T = raging libido/titanium erections.....LMFAO!</p><p></p><p>If it were only so simple.</p><p></p><p></p><p><strong>post# 6</strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/testosterone-and-erectile-function.16416/#post-124057[/URL]</p><p></p><p><strong>Key points</strong></p><p></p><p><em>■ Testosterone levels can reflect perturbations in all three dimensions (organic, intrapsychic, and relationship) of erectile dysfunction (ED)</em></p><p><em></em></p><p><em>■ Testosterone is important not only in controlling the mechanical process of penile erection but also controls male sexual behavior and attitudes</em></p><p><em></em></p><p><em>■ Testosterone replacement therapy (TRT) should be considered the first-line treatment in hypogonadal patients with ED</em></p><p><em></em></p><p><em><strong><em>■ TrT monotherapy might not be adequate in all cases of ED because of the <u>multifactorial pathophysiology of this disorder</u></em></strong></em></p><p><em></em></p><p><em>■ In these cases, combination therapy with phosphodiesterase 5 inhibitors might improve outcomes indirectly, several of the mechanisms that lead to erection and detumescence</em></p><p></p><p></p><p></p><p><strong>post #14</strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/my-trt-dilemma.18083/#post-142315[/URL]</p><p></p><p><strong>CONCLUSIONS</strong></p><p><strong></strong></p><p><strong><em>Overall, available data indicate that T represents an important modulator of all the steps involved in the regulation of the male sexual response cycle.</em></strong> <strong><em>This association is attenuated in the epidemiologic studies because, <u>besides hormones, other factors including organic, relational, and intrapsychic determinants can modulate androgens’ role</u>.</em></strong> Evidence arising from interventional studies confirms a possible role of TRT in ameliorating several aspects of sexual functioning including libido, erectile function, and overall sexual satisfaction. Conversely, data on the role of TRT in improving orgasmic function are more conflicting and analyzed only in a limited number of RCTs. It is important to recognize that, whatever outcome is considered, the effects of TRT are clearly evident only in the presence of hypogonadal status (ie, total T < 12 nmol/L), whereas the positive effects of TRT are no longer confirmed for higher T levels. <strong><em>In addition, TRT alone can be effective in restoring only milder forms of ED, <u>whereas the combined therapy with other drugs is required when more severe vascular damage is present</u>.</em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em>*<u>TRT alone can be effective in restoring only milder forms of ED</u>, whereas the combined therapy with other drugs is required when more severe vascular damage is present.</em></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>post#10</strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/pharmacology-and-perspectives-in-erectile-dysfunction-in-man.20458/[/URL]</p><p></p><p>For those that lack the understanding of the complexity of ED/libido.....a long but informative read!</p><p></p><p>So much more involved than simply having healthy hormones (testosterone, estradiol, DHT, prolactin, DHEA-S).</p><p></p><p></p><p><strong><em>*Penile erection is a perfect example of microcirculation modulated by <u>psychological factors and hormonal status</u>. <u>It is the result of a complex neurovascular process that involves the integrative synchronized action of vascular endothelium; smooth muscle; and psychological, neuronal, and hormonal systems</u>. <u>Therefore, the fine coordination of these events is essential to maintain penile flaccidity or allow erection; an ALTERATION OF THESE EVENTS leads to erectile dysfunction (ED)</u>.</em></strong></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/erectile-dysfunction-due-to-cavernovenous-leakage.20541/#post-171829[/URL]</p><p></p><p><strong><em>Erectile dysfunction (ED) is defined as the permanent or recurrent inability to achieve or maintain an erection of sufficient rigidity to permit satisfactory sexual activity. It is a frequent symptom more and more widely recognized and treated in numerous populations. Its prevalence increases with age insofar as it presently affects more than 30% of men under 40 and more than 50% of men from 40 to 70 years of age [1]. <u>It is a multifactorial pathology involving a mixture of functional (psychogenic) and organic (metabolic, neurovascular et endocrinal) aspects</u>.</em></strong></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/contemporary-considerations-in-the-pathophysiology-of-low-sex-drive-in-men.21766/[/URL]</p><p></p><p><em><strong>CONCLUSION</strong></em></p><p></p><p><strong><em>Assessment and treatment of HSDD in male patients require taking a <u>multifactorial perspective</u>.<u> Educating men about all potential factors that may be affecting their SD is critical to their recognition that multiple approaches to treatment may need to be used</u>. This approach fosters REALISTIC EXPECTATIONS and will likely lead to more SATISFACTORY OUTCOMES.</em></strong></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/does-trt-really-improve-sex-drive-and-function-in-older-men.22465/#post-193016[/URL]</p><p></p><p></p><p><strong>post #2</strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/long-term-treatment-of-ed-beyond-the-purely-symptomatic-use-of-pde5i.22518/[/URL]</p><p></p><p><em><strong>*A normal erection is based on a <u>meticulous interplay of hormonal, neuronal, and vascular processes, which can be compromised at the genetic, molecular, and microanatomical levels</u>.</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*We hope to contribute to a better therapeutic approach to the <u>multifactorial genesis of erectile dysfunction</u> and, in the medium term, to shift the therapy of erectile dysfunction away from a purely symptomatic character toward a more regenerative and perhaps curative approach.</strong></em></p><p></p><p><strong><em>*<u>It has been scientifically shown that the development of erectile dysfunction is a multifactorial process that is associated with conditions like metabolic syndrome, coronary heart disease, diabetes mellitus, hyperlipidemia, hypogonadism, trauma, prostate hyperplasia, depression, and numerous other psychological and physiological states which negatively affect nerve activity, hormone secretion and perception, blood supply and disposal, biochemical processes, and microanatomical structures</u>.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 204984, member: 13851"] Unfortunately, everyone is so caught up on higher T = raging libido/titanium erections.....LMFAO! If it were only so simple. [B]post# 6[/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/testosterone-and-erectile-function.16416/#post-124057[/URL] [B]Key points[/B] [I]■ Testosterone levels can reflect perturbations in all three dimensions (organic, intrapsychic, and relationship) of erectile dysfunction (ED) ■ Testosterone is important not only in controlling the mechanical process of penile erection but also controls male sexual behavior and attitudes ■ Testosterone replacement therapy (TRT) should be considered the first-line treatment in hypogonadal patients with ED [B][I]■ TrT monotherapy might not be adequate in all cases of ED because of the [U]multifactorial pathophysiology of this disorder[/U][/I][/B] ■ In these cases, combination therapy with phosphodiesterase 5 inhibitors might improve outcomes indirectly, several of the mechanisms that lead to erection and detumescence[/I] [B]post #14[/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/my-trt-dilemma.18083/#post-142315[/URL] [B]CONCLUSIONS [I]Overall, available data indicate that T represents an important modulator of all the steps involved in the regulation of the male sexual response cycle.[/I][/B] [B][I]This association is attenuated in the epidemiologic studies because, [U]besides hormones, other factors including organic, relational, and intrapsychic determinants can modulate androgens’ role[/U].[/I][/B] Evidence arising from interventional studies confirms a possible role of TRT in ameliorating several aspects of sexual functioning including libido, erectile function, and overall sexual satisfaction. Conversely, data on the role of TRT in improving orgasmic function are more conflicting and analyzed only in a limited number of RCTs. It is important to recognize that, whatever outcome is considered, the effects of TRT are clearly evident only in the presence of hypogonadal status (ie, total T < 12 nmol/L), whereas the positive effects of TRT are no longer confirmed for higher T levels. [B][I]In addition, TRT alone can be effective in restoring only milder forms of ED, [U]whereas the combined therapy with other drugs is required when more severe vascular damage is present[/U]. *[U]TRT alone can be effective in restoring only milder forms of ED[/U], whereas the combined therapy with other drugs is required when more severe vascular damage is present.[/I] post#10[/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/pharmacology-and-perspectives-in-erectile-dysfunction-in-man.20458/[/URL] For those that lack the understanding of the complexity of ED/libido.....a long but informative read! So much more involved than simply having healthy hormones (testosterone, estradiol, DHT, prolactin, DHEA-S). [B][I]*Penile erection is a perfect example of microcirculation modulated by [U]psychological factors and hormonal status[/U]. [U]It is the result of a complex neurovascular process that involves the integrative synchronized action of vascular endothelium; smooth muscle; and psychological, neuronal, and hormonal systems[/U]. [U]Therefore, the fine coordination of these events is essential to maintain penile flaccidity or allow erection; an ALTERATION OF THESE EVENTS leads to erectile dysfunction (ED)[/U].[/I][/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/erectile-dysfunction-due-to-cavernovenous-leakage.20541/#post-171829[/URL] [B][I]Erectile dysfunction (ED) is defined as the permanent or recurrent inability to achieve or maintain an erection of sufficient rigidity to permit satisfactory sexual activity. It is a frequent symptom more and more widely recognized and treated in numerous populations. Its prevalence increases with age insofar as it presently affects more than 30% of men under 40 and more than 50% of men from 40 to 70 years of age [1]. [U]It is a multifactorial pathology involving a mixture of functional (psychogenic) and organic (metabolic, neurovascular et endocrinal) aspects[/U].[/I][/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/contemporary-considerations-in-the-pathophysiology-of-low-sex-drive-in-men.21766/[/URL] [I][B]CONCLUSION[/B][/I] [B][I]Assessment and treatment of HSDD in male patients require taking a [U]multifactorial perspective[/U].[U] Educating men about all potential factors that may be affecting their SD is critical to their recognition that multiple approaches to treatment may need to be used[/U]. This approach fosters REALISTIC EXPECTATIONS and will likely lead to more SATISFACTORY OUTCOMES.[/I][/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/does-trt-really-improve-sex-drive-and-function-in-older-men.22465/#post-193016[/URL] [B]post #2[/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/long-term-treatment-of-ed-beyond-the-purely-symptomatic-use-of-pde5i.22518/[/URL] [I][B]*A normal erection is based on a [U]meticulous interplay of hormonal, neuronal, and vascular processes, which can be compromised at the genetic, molecular, and microanatomical levels[/U]. *We hope to contribute to a better therapeutic approach to the [U]multifactorial genesis of erectile dysfunction[/U] and, in the medium term, to shift the therapy of erectile dysfunction away from a purely symptomatic character toward a more regenerative and perhaps curative approach.[/B][/I] [B][I]*[U]It has been scientifically shown that the development of erectile dysfunction is a multifactorial process that is associated with conditions like metabolic syndrome, coronary heart disease, diabetes mellitus, hyperlipidemia, hypogonadism, trauma, prostate hyperplasia, depression, and numerous other psychological and physiological states which negatively affect nerve activity, hormone secretion and perception, blood supply and disposal, biochemical processes, and microanatomical structures[/U].[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Calling All Long-Term TRT Users! How is Your Libido and Sexual Function?
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