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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Caffeine Induced Emotion Blunting- Pregnenolone Crash
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<blockquote data-quote="electrify" data-source="post: 236628" data-attributes="member: 44439"><p>Hello,</p><p></p><p>Used to post on PeakT's forum years ago like back in 2015-2017. Since then I have pretty much been well and dialied in on a TRT protocol (I do 0.3 mL 2x a week). I don't take an AI, and things like high E2 or low SHBG (this declined from 25 over the years) have not really affected me. At some point also, low cortisol/pregnenolone on TRT also resolved themselves. I do supplement Preg Cream 15 mg daily. At that time my symptoms were more anxiety and low mood.</p><p></p><p>Anyways fast forward to this year. Suddenly 1 day completely randomly after drinking caffeine, I felt emotionally numb. I also did not have any anxiety or panic attack. This is *never* a symptom I had in my previous issues with T and the HPA axis back then. It seems to get better at night time, but basically I am not having the emotional response to things that I used to have. This is my only symptom mainly. Things like libido are still OK ish.</p><p></p><p>As it turned out, my pregnenolone levels took a massive dive out of nowhere. I'm not sure why this crazy reaction happened, its pretty intersting. I wonder if randomly having too high T levels made me super sensitive to caffeine.</p><p></p><p>My labs 5 months before this when I was normal:</p><p></p><p>T - 850</p><p>E2 - 63</p><p>SHBG - 15</p><p>Cortisol AM - 15</p><p>DHEAS - 550</p><p>Pregnenolone - 125</p><p></p><p>Labs now:</p><p></p><p>T - 1171</p><p>E2 - 54 (No idea why this went down despite T going up, maybe cause ive lost some ab fat)</p><p>SHBG - 14</p><p>Cortisol - 7.7</p><p>DHEA-S - 470</p><p>Pregnenolone - 35</p><p></p><p>How do you raise Preg + Cortisol? This blunting is pretty concerning, it seems like my body had some very weird sensitivity and stress reaction to the caffeine. I do notice a slight effect with the Preg cream, but not enough. It seems like my HPA axis got affected by this strange reaction.</p><p></p><p>I'm also wondering can symptoms morph over the years? Previously when I had these kind of labs way back, I had low mood+ anxiety. Now this time, my symptom is flat emotions but my mood is not low and I don't feel that anxious (well except over the symptom).</p><p></p><p>I've also noticed the same dose of T resulting in higher levels this time around. Seems ive gotten more sensitive to everything.</p></blockquote><p></p>
[QUOTE="electrify, post: 236628, member: 44439"] Hello, Used to post on PeakT's forum years ago like back in 2015-2017. Since then I have pretty much been well and dialied in on a TRT protocol (I do 0.3 mL 2x a week). I don't take an AI, and things like high E2 or low SHBG (this declined from 25 over the years) have not really affected me. At some point also, low cortisol/pregnenolone on TRT also resolved themselves. I do supplement Preg Cream 15 mg daily. At that time my symptoms were more anxiety and low mood. Anyways fast forward to this year. Suddenly 1 day completely randomly after drinking caffeine, I felt emotionally numb. I also did not have any anxiety or panic attack. This is *never* a symptom I had in my previous issues with T and the HPA axis back then. It seems to get better at night time, but basically I am not having the emotional response to things that I used to have. This is my only symptom mainly. Things like libido are still OK ish. As it turned out, my pregnenolone levels took a massive dive out of nowhere. I'm not sure why this crazy reaction happened, its pretty intersting. I wonder if randomly having too high T levels made me super sensitive to caffeine. My labs 5 months before this when I was normal: T - 850 E2 - 63 SHBG - 15 Cortisol AM - 15 DHEAS - 550 Pregnenolone - 125 Labs now: T - 1171 E2 - 54 (No idea why this went down despite T going up, maybe cause ive lost some ab fat) SHBG - 14 Cortisol - 7.7 DHEA-S - 470 Pregnenolone - 35 How do you raise Preg + Cortisol? This blunting is pretty concerning, it seems like my body had some very weird sensitivity and stress reaction to the caffeine. I do notice a slight effect with the Preg cream, but not enough. It seems like my HPA axis got affected by this strange reaction. I'm also wondering can symptoms morph over the years? Previously when I had these kind of labs way back, I had low mood+ anxiety. Now this time, my symptom is flat emotions but my mood is not low and I don't feel that anxious (well except over the symptom). I've also noticed the same dose of T resulting in higher levels this time around. Seems ive gotten more sensitive to everything. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Caffeine Induced Emotion Blunting- Pregnenolone Crash
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