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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Cabergoline Improves Orgasms in Two Thirds of Men
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<blockquote data-quote="Nelson Vergel" data-source="post: 34366" data-attributes="member: 3"><p><strong>Cabergoline in the Treatment of Male Orgasmic Disorder-A Retrospective Pilot Analysis.</strong></p><p></p><p>Hollander AB, et al. Sex Med. 2016.</p><p></p><p></p><p>Authors</p><p>Hollander AB1, Pastuszak AW2, Hsieh TC3, Johnson WG1, Scovell JM4, Mai CK1, Lipshultz LI4.</p><p>Author information</p><p>1Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.</p><p>2Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA; Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA. </p><p>3Department of Urology, University of California-San Diego, San Diego, CA, USA.</p><p>4Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA; Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA.</p><p>Citation</p><p>Sex Med. 2016 Mar;4(1):e28-33. doi: 10.1016/j.esxm.2015.09.001.</p><p></p><p></p><p>Abstract</p><p></p><p></p><p>INTRODUCTION: Male orgasmic disorder is common, with few treatment options. Cabergoline is a dopamine agonist that acts centrally to normalize serum prolactin that could improve orgasmic dysfunction.</p><p></p><p>AIMS: To determine whether cabergoline increases the potential for orgasm in men with orgasmic disorder.</p><p></p><p>METHODS: A retrospective chart review of men treated in a single andrology clinic for delayed orgasm or anorgasmia in a pilot study using cabergoline 0.5 mg twice weekly was performed. Duration of treatment and response were noted. Medical records were examined for other factors including history of prostatectomy and concomitant androgen supplementation.</p><p></p><p>MAIN OUTCOME MEASURES: Subjective improvement in orgasmic function resulting from cabergoline treatment.</p><p></p><p>RESULTS: Of 131 men treated with cabergoline for orgasmic disorder, 87 (66.4%) reported subjective improvement in orgasm and 44 (33.6%) reported no change in orgasm. Duration of therapy (P = .03) and concomitant testosterone therapy (P = .02) were associated with a significant positive response to cabergoline treatment. No differences were found between injectable and non-injectable testosterone formulations (P = .90), and neither age (P = .90) nor prior prostatectomy (P = .41) influenced the outcome of cabergoline treatment. Serum testosterone levels before (P = .26) and after (P = .81) treatment were not significantly different in responders vs non-responders.</p><p></p><p>CONCLUSION: Cabergoline is a potentially effective and easy-to-administer treatment for male orgasmic disorder, the efficacy of which appears to be independent of patient age or orgasmic disorder etiology. Prospective randomized trials are needed to determine the true role of cabergoline in the treatment of this disorder.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 34366, member: 3"] [B]Cabergoline in the Treatment of Male Orgasmic Disorder-A Retrospective Pilot Analysis.[/B] Hollander AB, et al. Sex Med. 2016. Authors Hollander AB1, Pastuszak AW2, Hsieh TC3, Johnson WG1, Scovell JM4, Mai CK1, Lipshultz LI4. Author information 1Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA. 2Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA; Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA. 3Department of Urology, University of California-San Diego, San Diego, CA, USA. 4Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA; Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA. Citation Sex Med. 2016 Mar;4(1):e28-33. doi: 10.1016/j.esxm.2015.09.001. Abstract INTRODUCTION: Male orgasmic disorder is common, with few treatment options. Cabergoline is a dopamine agonist that acts centrally to normalize serum prolactin that could improve orgasmic dysfunction. AIMS: To determine whether cabergoline increases the potential for orgasm in men with orgasmic disorder. METHODS: A retrospective chart review of men treated in a single andrology clinic for delayed orgasm or anorgasmia in a pilot study using cabergoline 0.5 mg twice weekly was performed. Duration of treatment and response were noted. Medical records were examined for other factors including history of prostatectomy and concomitant androgen supplementation. MAIN OUTCOME MEASURES: Subjective improvement in orgasmic function resulting from cabergoline treatment. RESULTS: Of 131 men treated with cabergoline for orgasmic disorder, 87 (66.4%) reported subjective improvement in orgasm and 44 (33.6%) reported no change in orgasm. Duration of therapy (P = .03) and concomitant testosterone therapy (P = .02) were associated with a significant positive response to cabergoline treatment. No differences were found between injectable and non-injectable testosterone formulations (P = .90), and neither age (P = .90) nor prior prostatectomy (P = .41) influenced the outcome of cabergoline treatment. Serum testosterone levels before (P = .26) and after (P = .81) treatment were not significantly different in responders vs non-responders. CONCLUSION: Cabergoline is a potentially effective and easy-to-administer treatment for male orgasmic disorder, the efficacy of which appears to be independent of patient age or orgasmic disorder etiology. Prospective randomized trials are needed to determine the true role of cabergoline in the treatment of this disorder. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Cabergoline Improves Orgasms in Two Thirds of Men
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