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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
BOTOX for Erectile Dysfunction- Yes, Really.
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<blockquote data-quote="Nelson Vergel" data-source="post: 87143" data-attributes="member: 3"><p><span style="color: #2E2E2E"><span style="font-family: 'Arial'">The human RCT involved 24 men with severe vasculogenic ED diagnosed by penile duplex and refractory to PDE5 inhibitors (PDE5Is) and intracavernosal injection (ICI) therapy with tri-mix, with penile prosthesis insertion being their only option. Only patients with a “no” response to Sexual Encounter Profile questions 2 and 3 were included in the study. The patients were randomized to the intervention and control groups (1:1). Assessment for the two groups was done by penile color Doppler study and the Erection Hardness Score at baseline and 2 weeks after treatment, respectively, in addition to the Sexual Health Inventory for Men (SHIM) questionnaire and Sexual Encounter Profile questions 2 and 3 at baseline and 4 weeks after treatment, respectively.[SUP]<a href="http://www.sciencedirect.com/science/article/pii/S2050052117300859#bib3" target="_blank">3</a>; <a href="http://www.sciencedirect.com/science/article/pii/S2050052117300859#bib4" target="_blank">4</a>; <a href="http://www.sciencedirect.com/science/article/pii/S2050052117300859#bib5" target="_blank">5</a> ; <a href="http://www.sciencedirect.com/science/article/pii/S2050052117300859#bib6" target="_blank">6</a></span></span></p><p><span style="color: #2E2E2E"><span style="font-family: 'Arial'">[/SUP]</span></span></p><p><span style="color: #2E2E2E"><span style="font-family: 'Arial'"><strong>The intervention group received a single ICI of Botox 50 U and the control group received a single ICI of 0.9% normal saline 1 mL. To decrease the risk of systemic absorption, compression of the penile base was applied using a rubber band placed over the base of the penis before the injection and removed after 20 minutes</strong> (<a href="http://www.sciencedirect.com/science/article/pii/S2050052117300859#fig2" target="_blank">Figure 2</a>). After injection with BoNT-A, there was a statistically significant improvement in the mean peak systolic velocity in the treatment group from 24.6 cm/s at baseline to 34.9 cm/s (<em>P</em> = 0.005) but not in the control group ( <a href="http://www.sciencedirect.com/science/article/pii/S2050052117300859#fig3" target="_blank">Figure 3</a>). There also was a statistically significant improvement in the mean SHIM score (from 5.58 to 10.25; <em>P</em> = 0.0075) and the mean Erection Hardness Score (from 2 to 2.75; <em>P</em> = 0.01; <a href="http://www.sciencedirect.com/science/article/pii/S2050052117300859#fig4" target="_blank">Figure 4</a>). Of the 12 patients in the treatment group, 7 could engage in penetrative sex with their partners with the help of sildenafil 100 mg compared with two patients from the control group, with the erection lasting long enough to complete intercourse in 3 of the 7 patients from the treatment group vs none from the control group (<a href="http://www.sciencedirect.com/science/article/pii/S2050052117300859#fig5" target="_blank">Figure 5</a>). One patient in the treatment group experienced a 2.5-hour prolonged erection during the post-treatment penile color Doppler study with the tri-mix injection that required an ephedrine ICI. However, there were no episodes of priapism or systemic toxicity. [SUP]<a href="http://www.sciencedirect.com/science/article/pii/S2050052117300859#bib3" target="_blank">3</a>; <a href="http://www.sciencedirect.com/science/article/pii/S2050052117300859#bib4" target="_blank">4</a>; <a href="http://www.sciencedirect.com/science/article/pii/S2050052117300859#bib5" target="_blank">5</a> ; <a href="http://www.sciencedirect.com/science/article/pii/S2050052117300859#bib6" target="_blank">6</a>[/SUP]</span></span></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 87143, member: 3"] [COLOR=#2E2E2E][FONT=Arial]The human RCT involved 24 men with severe vasculogenic ED diagnosed by penile duplex and refractory to PDE5 inhibitors (PDE5Is) and intracavernosal injection (ICI) therapy with tri-mix, with penile prosthesis insertion being their only option. Only patients with a “no” response to Sexual Encounter Profile questions 2 and 3 were included in the study. The patients were randomized to the intervention and control groups (1:1). Assessment for the two groups was done by penile color Doppler study and the Erection Hardness Score at baseline and 2 weeks after treatment, respectively, in addition to the Sexual Health Inventory for Men (SHIM) questionnaire and Sexual Encounter Profile questions 2 and 3 at baseline and 4 weeks after treatment, respectively.[SUP][URL="http://www.sciencedirect.com/science/article/pii/S2050052117300859#bib3"]3[/URL]; [URL="http://www.sciencedirect.com/science/article/pii/S2050052117300859#bib4"]4[/URL]; [URL="http://www.sciencedirect.com/science/article/pii/S2050052117300859#bib5"]5[/URL] ; [URL="http://www.sciencedirect.com/science/article/pii/S2050052117300859#bib6"]6[/URL] [/SUP][/FONT][/COLOR] [COLOR=#2E2E2E][FONT=Arial][B]The intervention group received a single ICI of Botox 50 U and the control group received a single ICI of 0.9% normal saline 1 mL. To decrease the risk of systemic absorption, compression of the penile base was applied using a rubber band placed over the base of the penis before the injection and removed after 20 minutes[/B] ([URL="http://www.sciencedirect.com/science/article/pii/S2050052117300859#fig2"]Figure 2[/URL]). After injection with BoNT-A, there was a statistically significant improvement in the mean peak systolic velocity in the treatment group from 24.6 cm/s at baseline to 34.9 cm/s ([I]P[/I] = 0.005) but not in the control group ( [URL="http://www.sciencedirect.com/science/article/pii/S2050052117300859#fig3"]Figure 3[/URL]). There also was a statistically significant improvement in the mean SHIM score (from 5.58 to 10.25; [I]P[/I] = 0.0075) and the mean Erection Hardness Score (from 2 to 2.75; [I]P[/I] = 0.01; [URL="http://www.sciencedirect.com/science/article/pii/S2050052117300859#fig4"]Figure 4[/URL]). Of the 12 patients in the treatment group, 7 could engage in penetrative sex with their partners with the help of sildenafil 100 mg compared with two patients from the control group, with the erection lasting long enough to complete intercourse in 3 of the 7 patients from the treatment group vs none from the control group ([URL="http://www.sciencedirect.com/science/article/pii/S2050052117300859#fig5"]Figure 5[/URL]). One patient in the treatment group experienced a 2.5-hour prolonged erection during the post-treatment penile color Doppler study with the tri-mix injection that required an ephedrine ICI. However, there were no episodes of priapism or systemic toxicity. [SUP][URL="http://www.sciencedirect.com/science/article/pii/S2050052117300859#bib3"]3[/URL]; [URL="http://www.sciencedirect.com/science/article/pii/S2050052117300859#bib4"]4[/URL]; [URL="http://www.sciencedirect.com/science/article/pii/S2050052117300859#bib5"]5[/URL] ; [URL="http://www.sciencedirect.com/science/article/pii/S2050052117300859#bib6"]6[/URL][/SUP][/FONT][/COLOR] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
BOTOX for Erectile Dysfunction- Yes, Really.
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