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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Bone health in aging men
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<blockquote data-quote="madman" data-source="post: 231032" data-attributes="member: 13851"><p><strong>Fig. 1 <u>Impact of sex steroids on fracture development in older community-dwelling men versus hypogonadal men</u>. Several arguments favoring a ‘bone threshold’ of T levels in age-related bone loss in men are available. In aging rats, TRT which is not sufficient for restoring androgen-sensitive organs weights is effective in maintaining BMD and preventing bone resorption [109]. <u>In healthy men who are sex steroid deprived and subsequently treated with different doses of TRT, increased bone resorption is only present when T levels are <200 ng/dL</u>. [104] <u>A similar experiment in older men shows a loss in vBMD at the spine only occurs when T levels are <200 ng/dL</u>. [108] In an observational study in elderly men, the odds of having osteoporosis at the hip triples, as does the odds of experiencing rapid hip bone loss in men with baseline T levels <200 ng/dL compared to men with T levels>500 ng/dL. [127] <u>Finally, the results of TRT on BMD increase are more pronounced in patients with T levels<200 ng/dL than in patients with higher levels.</u> [258] [259] These data suggest that the relatively small decline in sex steroid concentrations in older community-dwelling men only limitedly contributes to the pathogenesis of osteoporosis, while in hypogonadal osteoporosis the severe sex steroid deficiency is considered to be the main driver of increased fracture risk. (*) In patients with underlying comorbidities such as cancer, a decline in sex steroid levels may be accelerated compared to ‘healthy’ community-dwelling men. If this greater decline in sex steroid levels negatively impacts bone health in these patients with this ‘pathological ageing’-phenotype remains to be elucidated. The effects of TRT on BMD in this population are underexplored as well. Dotted arrows indicate rather weak or uncertain effects. Created with BioRender.com</strong></p><p><strong>[ATTACH=full]24876[/ATTACH]</strong></p><p><strong>[ATTACH=full]24877[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 231032, member: 13851"] [B]Fig. 1 [U]Impact of sex steroids on fracture development in older community-dwelling men versus hypogonadal men[/U]. Several arguments favoring a ‘bone threshold’ of T levels in age-related bone loss in men are available. In aging rats, TRT which is not sufficient for restoring androgen-sensitive organs weights is effective in maintaining BMD and preventing bone resorption [109]. [U]In healthy men who are sex steroid deprived and subsequently treated with different doses of TRT, increased bone resorption is only present when T levels are <200 ng/dL[/U]. [104] [U]A similar experiment in older men shows a loss in vBMD at the spine only occurs when T levels are <200 ng/dL[/U]. [108] In an observational study in elderly men, the odds of having osteoporosis at the hip triples, as does the odds of experiencing rapid hip bone loss in men with baseline T levels <200 ng/dL compared to men with T levels>500 ng/dL. [127] [U]Finally, the results of TRT on BMD increase are more pronounced in patients with T levels<200 ng/dL than in patients with higher levels.[/U] [258] [259] These data suggest that the relatively small decline in sex steroid concentrations in older community-dwelling men only limitedly contributes to the pathogenesis of osteoporosis, while in hypogonadal osteoporosis the severe sex steroid deficiency is considered to be the main driver of increased fracture risk. (*) In patients with underlying comorbidities such as cancer, a decline in sex steroid levels may be accelerated compared to ‘healthy’ community-dwelling men. If this greater decline in sex steroid levels negatively impacts bone health in these patients with this ‘pathological ageing’-phenotype remains to be elucidated. The effects of TRT on BMD in this population are underexplored as well. Dotted arrows indicate rather weak or uncertain effects. Created with BioRender.com [ATTACH type="full"]24876[/ATTACH] [ATTACH type="full"]24877[/ATTACH][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Bone health in aging men
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