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<blockquote data-quote="madman" data-source="post: 276911" data-attributes="member: 13851"><p>Forget getting caught up in trying to lower SHBG.</p><p></p><p>Increasing your TT will drive up your FT.</p><p></p><p>Increasing your FT will incease your estradiol.</p><p></p><p>Larger doses injected less frequently would have a bigger impact on driving down SHBG.</p><p></p><p>Even than not everyone will see a big drop in SHBG when using therapeutic doses of T.</p><p></p><p>My SHBG has barely budged during the 7 years I have been on TTh and I inject 150 mg T/week split into twice-weely injections (every 3.5 days).</p><p></p><p>I run a high-end trough FT.</p><p></p><p>Keep in mind that although TT is important to know FT is what truly matters as it is the active unbound fraction of testosterone responsible for the positive effects.</p><p></p><p>Unfortunately, you had your FT tested using the known to be inaccurate direct immunoassay.</p><p></p><p>You need to have your FT tested using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration, especially in cases of altered SHBG to know where it truly sits.</p><p></p><p>If you do not have access to such assays, highly doubtful if you live in the US then you would need to use/rely upon the linear law-of-mass action cFTV.</p><p></p><p>It is available online for free.</p><p></p><p>Plug in your TT, SHBG, and Albumin to see where your FT sits.</p><p></p><p>With a whopping TT 1487 ng/dL, high SHBG 57 nmol/L, and Albumin 4.3 g/dL (default) your FT 28.9 ng/dL would be high.</p><p></p><p>As you can see with a whopping TT of almost 1500 ng/dL even with a high SHBG of 57 nmol/L your FT is high!</p><p></p><p>[ATTACH=full]42089[/ATTACH]</p><p></p><p>Keep in mind as of now cFTV tends to overestimate sligtly when copared against a standardized Equilibrium Dialysis assay.</p><p></p><p>So although your FT level may very well be a little lower ifyou had it tested using the most accurate assay (ED) it would still be on the high-end/high.</p><p></p><p>You are missing critical blood markers RBCs, hemoglobin, and hematocrit which need to be done when using exogenous T.</p><p></p><p>This is important and needs to be addressed.</p><p></p><p>Keep in mind that when starting TTh or tweaking a protocol (increasing dose of T) hematocrit will increase within the first month and will take 6-9 months and in some cases a year to reach peak levels.</p><p></p><p>Where your levels sit 6-8 weeks let alone 3 months in is not where they will end up 6-9 months from now.</p><p></p><p>If you feel good overall, minus any sides, and your blood markers are healthy then stick with it for the time being!</p><p></p><p>If shit goes south down the road then you easily have room to bring down your FT level if need be.</p><p></p><p>Keep in mind you are only 8 weeks in and you need to give it more time to truly gauge how you feel.</p><p></p><p>Many fail to realize that when first starting TTh let alone tweaking a protocol (increasing dose of T) hormones will be in flux during the weeks leading up until blood levels have stabilized (4-6 weeks TC/TE) and it is common to experience ups/downs during the transition as the body is trying to adjust.</p><p></p><p>More importantly, once blood levels have stabilized (4-6 weeks) it will still take time (a few more months) for the body to adapt to its new set-point and this is the critical time when one needs to gauge how they truly feel overall regarding relief/improvement of low-symptoms and overall well-being.</p><p></p><p>Every protocol needs to be given 12 weeks before claiming whether it was a success or failure.</p><p></p><p>Patience is key.</p></blockquote><p></p>
[QUOTE="madman, post: 276911, member: 13851"] Forget getting caught up in trying to lower SHBG. Increasing your TT will drive up your FT. Increasing your FT will incease your estradiol. Larger doses injected less frequently would have a bigger impact on driving down SHBG. Even than not everyone will see a big drop in SHBG when using therapeutic doses of T. My SHBG has barely budged during the 7 years I have been on TTh and I inject 150 mg T/week split into twice-weely injections (every 3.5 days). I run a high-end trough FT. Keep in mind that although TT is important to know FT is what truly matters as it is the active unbound fraction of testosterone responsible for the positive effects. Unfortunately, you had your FT tested using the known to be inaccurate direct immunoassay. You need to have your FT tested using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration, especially in cases of altered SHBG to know where it truly sits. If you do not have access to such assays, highly doubtful if you live in the US then you would need to use/rely upon the linear law-of-mass action cFTV. It is available online for free. Plug in your TT, SHBG, and Albumin to see where your FT sits. With a whopping TT 1487 ng/dL, high SHBG 57 nmol/L, and Albumin 4.3 g/dL (default) your FT 28.9 ng/dL would be high. As you can see with a whopping TT of almost 1500 ng/dL even with a high SHBG of 57 nmol/L your FT is high! [ATTACH type="full"]42089[/ATTACH] Keep in mind as of now cFTV tends to overestimate sligtly when copared against a standardized Equilibrium Dialysis assay. So although your FT level may very well be a little lower ifyou had it tested using the most accurate assay (ED) it would still be on the high-end/high. You are missing critical blood markers RBCs, hemoglobin, and hematocrit which need to be done when using exogenous T. This is important and needs to be addressed. Keep in mind that when starting TTh or tweaking a protocol (increasing dose of T) hematocrit will increase within the first month and will take 6-9 months and in some cases a year to reach peak levels. Where your levels sit 6-8 weeks let alone 3 months in is not where they will end up 6-9 months from now. If you feel good overall, minus any sides, and your blood markers are healthy then stick with it for the time being! If shit goes south down the road then you easily have room to bring down your FT level if need be. Keep in mind you are only 8 weeks in and you need to give it more time to truly gauge how you feel. Many fail to realize that when first starting TTh let alone tweaking a protocol (increasing dose of T) hormones will be in flux during the weeks leading up until blood levels have stabilized (4-6 weeks TC/TE) and it is common to experience ups/downs during the transition as the body is trying to adjust. More importantly, once blood levels have stabilized (4-6 weeks) it will still take time (a few more months) for the body to adapt to its new set-point and this is the critical time when one needs to gauge how they truly feel overall regarding relief/improvement of low-symptoms and overall well-being. Every protocol needs to be given 12 weeks before claiming whether it was a success or failure. Patience is key. [/QUOTE]
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