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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Blood test results (advice)
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<blockquote data-quote="madman" data-source="post: 222892" data-attributes="member: 13851"><p><em><strong>I’ve been on TRT for the last 10 months after ending a pretty hefty blast cycle.</strong></em></p><p><strong><em>my TRT dose has been 300mg/week up until results came back then back down to 200mg/week.</em></strong></p><p></p><p>300 mg/week is a ridiculous dose for trt let alone the majority would never need 200-250 mg T/week to achieve a healthy, high let alone absurdly high FT level.</p><p></p><p>Most men are injecting 100-200 mg T/week whether injecting once weekly, twice-weekly (every 3.5 days), M/W/F, EOD, or daily.</p><p></p><p>Even then most can easily achieve a healthy, high let alone absurdly high FT by injecting <200 mg T/week, especially when split into more frequent injections.</p><p></p><p>Although TT is important to know FT is what truly matters as it is the active unbound fraction of testosterone responsible for the positive effects.</p><p></p><p>FT 5-10 ng/dL would be considered low.</p><p></p><p>FT 16-31 ng/dl (high-end) is healthy.</p><p></p><p>Most men will do well with FT 20-30 ng/dL.</p><p></p><p>Some may choose/want to run higher levels.</p><p></p><p>Comes down to the individual.</p><p></p><p></p><p></p><p></p><p><strong><em><u>Protocol prior to labs was 300mg test e per week</u>, no ai, 550mg HCG 3 times weekly.</em></strong></p><p></p><p>What is your injection frequency?</p><p></p><p>Where does your SHBG sit?</p><p></p><p>When were labs done?</p><p></p><p>Testing should be done at true trough just before your next injection.</p><p></p><p>It is a given that your trough TT, FT, and estradiol levels will be high/absurdly high let alone peak levels will be much higher (depending on injection frequency).</p><p></p><p>Top it off that most would be struggling with elevated RBCs/hemoglobin/hematocrit.</p><p></p><p>As you can clearly see your TT <1500 ng/dL is absurdly high and more importantly your FT would be absurdly high even if you had highish/high SHBG.</p><p></p><p>Good chance your SHBG is low/lowish due to your previous blast/cruising let alone from the absurdly high dose of 300mg T/week.</p><p></p><p>Even then you have no clue where your TT truly sits as you had it tested using the wrong assay the<strong> <em>electrochemiluminescence immunoassay (ECLIA) which caps out at 1500 ng/dL.</em></strong></p><p></p><p>You would need to use the most accurate assay <strong><em>LC/MS-MS-No upper limit.</em></strong></p><p></p><p>More importantly, you have no clue where your FT level truly sits as you had it tested using the<strong><em> piss poor known to be inaccurate direct immunoassay!</em></strong></p><p></p><p></p><p>[URL unfurl="true"]https://www.labcorp.com/tests/140103/testosterone-free-direct-with-total-testosterone[/URL]</p><p></p><p><strong>Methodology:</strong> <strong><u>Free</u>:</strong> <em>Direct analog enzyme immunoassay (EIA); <strong><u>Total</u>:</strong> electrochemiluminescence immunoassay (ECLIA)</em></p><p></p><p>The only way to know where your FT level truly sits is to have it tested using the most accurate assays such as Equilibrium Dialysis or Ultrafiltration (next best).</p><p></p><p>This is critical!</p><p></p><p>These are the tests/assays everyone should be using/relying upon.</p><p></p><p>Any one of these would suffice.</p><p></p><p>Most are using #2/3.</p><p></p><p></p><p><strong><u>Labcorp</u></strong></p><p></p><p>1. <a href="https://www.labcorp.com/tests/500726/testosterone-free-mass-spectrometry-equilibrium-dialysis-endocrine-sciences" target="_blank">500726: Testosterone, Free, Mass Spectrometry/Equilibrium Dialysis (Endocrine Sciences) | Labcorp</a></p><p></p><p><strong><u>Free</u>:</strong><em> equilibrium dialysis; </em><strong><u>tota</u>l:</strong><em> liquid chromatography/tandem mass spectrometry (LC/MS-MS)</em></p><p></p><p></p><p>2. <a href="https://www.labcorp.com/tests/070038/testosterone-free-equilibrium-ultrafiltration-with-total-testosterone-lc-ms-ms" target="_blank">070038: Testosterone, Free, Equilibrium Ultrafiltration With Total Testosterone, LC/MS-MS | Labcorp</a></p><p></p><p><strong><u>Free</u>:</strong><em> equilibrium ultrafiltration; </em><strong><u>tota</u>l:</strong><em> liquid chromatography/tandem mass spectrometry (LC/MS-MS)</em></p><p></p><p></p><p></p><p><strong><u>Quest Diagnostics</u></strong></p><p></p><p>3. <a href="https://www.discountedlabs.com/testosterone-free-dialysis-and-total-ls-ms-ms" target="_blank">Testosterone, Total, LC/MS and Free (Equilibrium Dialysis)</a></p><p></p><p><strong><u>Free</u>:</strong><em> equilibrium dialysis; </em><strong><u>tota</u>l:</strong><em> liquid chromatography/tandem mass spectrometry (LC/MS-MS)</em></p><p></p><p></p><p></p><p></p><p><strong><em>I did start adex @ twice a week after seeing e2 results, <u>I was a bit surprised to see e2 so high</u> as I wasn’t experiencing any sides besides bloating.</em></strong></p><p></p><p>Would be a given that your estradiol would be through the roof with a TT >1500 ng/dL which would have your FT level absurdly high.</p><p></p><p>Even then you did not have your e2 tested using the most accurate assay (LC/MS-MS).</p><p></p><p></p><p></p><p></p><p><em><strong>I’m going to have bloods done again in 5 days, this time i’ll be using quest, going thru discounted labs.</strong></em></p><p><em><strong>Will i be able to compare the 2 tests accurately even tho the first was done with labcorps?</strong></em></p><p></p><p>No.</p><p></p><p>You would need to use the same lab/same assays and you would need to use the most accurate assays TT/estradiol (LC/MS-MS) and FT (Equilibrium Dialysis or Ultrafiltration).</p><p></p><p></p><p><em><strong>Looking at the first test done via Labcorp looks like i hit the cut off for TT and FT?</strong></em></p><p></p><p>Your TT capped out at 1500 ng/L due to the assay used (analytical measurement range).</p><p></p><p>Forget worrying about your FT as it was tested using the piss poor known to be inaccurate direct immunoassay.</p><p></p><p>Your FT is going to be absurdly high running a TT >1500 ng/dL even if you had high/highish SHBG.</p><p></p><p></p><p></p><p></p><p><strong><em>I believe i read the testing for quest has no upper limit?</em></strong></p><p></p><p>Total Testosterone:</p><p></p><p>– <strong><em> Liquid chromatography-tandem mass spectrometry (LC/MS/MS)- No upper limit</em></strong></p><p></p><p>– Analytical sensitivity: 1.0 ng/dL</p><p></p><p>– Analytical specificity: no cross-reactivity with other steroid compounds</p><p></p><p>– <strong><em> Analytical Measurement Range: <u>1.0 ng/dL to 2,000 ng/dL</u></em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 222892, member: 13851"] [I][B]I’ve been on TRT for the last 10 months after ending a pretty hefty blast cycle.[/B][/I] [B][I]my TRT dose has been 300mg/week up until results came back then back down to 200mg/week.[/I][/B] 300 mg/week is a ridiculous dose for trt let alone the majority would never need 200-250 mg T/week to achieve a healthy, high let alone absurdly high FT level. Most men are injecting 100-200 mg T/week whether injecting once weekly, twice-weekly (every 3.5 days), M/W/F, EOD, or daily. Even then most can easily achieve a healthy, high let alone absurdly high FT by injecting <200 mg T/week, especially when split into more frequent injections. Although TT is important to know FT is what truly matters as it is the active unbound fraction of testosterone responsible for the positive effects. FT 5-10 ng/dL would be considered low. FT 16-31 ng/dl (high-end) is healthy. Most men will do well with FT 20-30 ng/dL. Some may choose/want to run higher levels. Comes down to the individual. [B][I][U]Protocol prior to labs was 300mg test e per week[/U], no ai, 550mg HCG 3 times weekly.[/I][/B] What is your injection frequency? Where does your SHBG sit? When were labs done? Testing should be done at true trough just before your next injection. It is a given that your trough TT, FT, and estradiol levels will be high/absurdly high let alone peak levels will be much higher (depending on injection frequency). Top it off that most would be struggling with elevated RBCs/hemoglobin/hematocrit. As you can clearly see your TT <1500 ng/dL is absurdly high and more importantly your FT would be absurdly high even if you had highish/high SHBG. Good chance your SHBG is low/lowish due to your previous blast/cruising let alone from the absurdly high dose of 300mg T/week. Even then you have no clue where your TT truly sits as you had it tested using the wrong assay the[B] [I]electrochemiluminescence immunoassay (ECLIA) which caps out at 1500 ng/dL.[/I][/B] You would need to use the most accurate assay [B][I]LC/MS-MS-No upper limit.[/I][/B] More importantly, you have no clue where your FT level truly sits as you had it tested using the[B][I] piss poor known to be inaccurate direct immunoassay![/I][/B] [URL unfurl="true"]https://www.labcorp.com/tests/140103/testosterone-free-direct-with-total-testosterone[/URL] [B]Methodology:[/B] [B][U]Free[/U]:[/B] [I]Direct analog enzyme immunoassay (EIA); [B][U]Total[/U]:[/B] electrochemiluminescence immunoassay (ECLIA)[/I] The only way to know where your FT level truly sits is to have it tested using the most accurate assays such as Equilibrium Dialysis or Ultrafiltration (next best). This is critical! These are the tests/assays everyone should be using/relying upon. Any one of these would suffice. Most are using #2/3. [B][U]Labcorp[/U][/B] 1. [URL='https://www.labcorp.com/tests/500726/testosterone-free-mass-spectrometry-equilibrium-dialysis-endocrine-sciences']500726: Testosterone, Free, Mass Spectrometry/Equilibrium Dialysis (Endocrine Sciences) | Labcorp[/URL] [B][U]Free[/U]:[/B][I] equilibrium dialysis; [/I][B][U]tota[/U]l:[/B][I] liquid chromatography/tandem mass spectrometry (LC/MS-MS)[/I] 2. [URL='https://www.labcorp.com/tests/070038/testosterone-free-equilibrium-ultrafiltration-with-total-testosterone-lc-ms-ms']070038: Testosterone, Free, Equilibrium Ultrafiltration With Total Testosterone, LC/MS-MS | Labcorp[/URL] [B][U]Free[/U]:[/B][I] equilibrium ultrafiltration; [/I][B][U]tota[/U]l:[/B][I] liquid chromatography/tandem mass spectrometry (LC/MS-MS)[/I] [B][U]Quest Diagnostics[/U][/B] 3. [URL='https://www.discountedlabs.com/testosterone-free-dialysis-and-total-ls-ms-ms']Testosterone, Total, LC/MS and Free (Equilibrium Dialysis)[/URL] [B][U]Free[/U]:[/B][I] equilibrium dialysis; [/I][B][U]tota[/U]l:[/B][I] liquid chromatography/tandem mass spectrometry (LC/MS-MS)[/I] [B][I]I did start adex @ twice a week after seeing e2 results, [U]I was a bit surprised to see e2 so high[/U] as I wasn’t experiencing any sides besides bloating.[/I][/B] Would be a given that your estradiol would be through the roof with a TT >1500 ng/dL which would have your FT level absurdly high. Even then you did not have your e2 tested using the most accurate assay (LC/MS-MS). [I][B]I’m going to have bloods done again in 5 days, this time i’ll be using quest, going thru discounted labs. Will i be able to compare the 2 tests accurately even tho the first was done with labcorps?[/B][/I] No. You would need to use the same lab/same assays and you would need to use the most accurate assays TT/estradiol (LC/MS-MS) and FT (Equilibrium Dialysis or Ultrafiltration). [I][B]Looking at the first test done via Labcorp looks like i hit the cut off for TT and FT?[/B][/I] Your TT capped out at 1500 ng/L due to the assay used (analytical measurement range). Forget worrying about your FT as it was tested using the piss poor known to be inaccurate direct immunoassay. Your FT is going to be absurdly high running a TT >1500 ng/dL even if you had high/highish SHBG. [B][I]I believe i read the testing for quest has no upper limit?[/I][/B] Total Testosterone: – [B][I] Liquid chromatography-tandem mass spectrometry (LC/MS/MS)- No upper limit[/I][/B] – Analytical sensitivity: 1.0 ng/dL – Analytical specificity: no cross-reactivity with other steroid compounds – [B][I] Analytical Measurement Range: [U]1.0 ng/dL to 2,000 ng/dL[/U][/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Blood test results (advice)
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