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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Blood Pressure Meds
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<blockquote data-quote="Blackhawk" data-source="post: 111508" data-attributes="member: 16042"><p>Some info here at 50:00 minutes about the benefits of "sartan" type BP meds in context of TRT (and the impotance of adequate estrogen): <a href="https://www.youtube.com/watch?v=a9sbWHAmVrA" target="_blank">https://www.youtube.com/watch?v=a9sbWHAmVrA</a></p><p></p><p>Unfortunately Jay mistakes what Sakas is saying about "sartans" as "statins" which temporarily derails/sidetracks the discussion, but it comes back on point at 53:43, then is sidetracked again, then comes back to the specific recommendation for Telmisartan at: 1:06:20 </p><p></p><p>Rough summary: “Sartan” type BPmeds (lorsartan telmisartan): 2 fold effect: angiotensin 2 type 1 receptor blocker which blocks the hypertrophic effect of angiotensin binding to this receptor, plus leaves angiotensin 2 free to bind at angiotensin 2 type 2 receptor which also mediates/improves anti hypertrophic response. </p><p></p><p>(Note: The discussion is based on the long term effect of TRT that is angiotensin related and drives cardiac hypertrophy. So the sartan type BP meds are great choices for men on TRT)</p><p></p><p>Telimsartan specifically has an extra beneficial mechanism as agonist of (activates) peroxisome proliferative activated receptors which increases insulin sensitvity.</p></blockquote><p></p>
[QUOTE="Blackhawk, post: 111508, member: 16042"] Some info here at 50:00 minutes about the benefits of "sartan" type BP meds in context of TRT (and the impotance of adequate estrogen): [URL]https://www.youtube.com/watch?v=a9sbWHAmVrA[/URL] Unfortunately Jay mistakes what Sakas is saying about "sartans" as "statins" which temporarily derails/sidetracks the discussion, but it comes back on point at 53:43, then is sidetracked again, then comes back to the specific recommendation for Telmisartan at: 1:06:20 Rough summary: “Sartan” type BPmeds (lorsartan telmisartan): 2 fold effect: angiotensin 2 type 1 receptor blocker which blocks the hypertrophic effect of angiotensin binding to this receptor, plus leaves angiotensin 2 free to bind at angiotensin 2 type 2 receptor which also mediates/improves anti hypertrophic response. (Note: The discussion is based on the long term effect of TRT that is angiotensin related and drives cardiac hypertrophy. So the sartan type BP meds are great choices for men on TRT) Telimsartan specifically has an extra beneficial mechanism as agonist of (activates) peroxisome proliferative activated receptors which increases insulin sensitvity. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Blood Pressure Meds
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