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Testosterone Replacement, Low T, HCG, & Beyond
When TRT Is Not Enough (ED, Libido, & More)
Beyond ED: cGMP-Specific PDE5i for Other Clinical Disorders
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<blockquote data-quote="madman" data-source="post: 242788" data-attributes="member: 13851"><p><strong>SUMMARY POINTS </strong></p><p></p><p><em><strong>1. Phosphodiesterase 5 (PDE5) is involved in the pathophysiology of several diseases due to dysregulated nitric oxide–cGMP–protein kinase G signaling </strong></em></p><p><em><strong></strong></em></p><p><em><strong>2. Because of the widespread expression of PDE5 in numerous tissues and organs, it is a target for the potential treatment of various diseases </strong></em></p><p><em><strong></strong></em></p><p><em><strong>3. PDE5 inhibitors, including sildenafil, are clinically used to manage erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract symptoms of benign prostatic hyperplasia </strong></em></p><p><em><strong></strong></em></p><p><strong><em>4. Experimental results and some clinical data suggest the potential for PDE5 inhibitors in the treatment of diseases that include cardiovascular disorders, Alzheimer’s disease, and cancer, among others</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 242788, member: 13851"] [B]SUMMARY POINTS [/B] [I][B]1. Phosphodiesterase 5 (PDE5) is involved in the pathophysiology of several diseases due to dysregulated nitric oxide–cGMP–protein kinase G signaling 2. Because of the widespread expression of PDE5 in numerous tissues and organs, it is a target for the potential treatment of various diseases 3. PDE5 inhibitors, including sildenafil, are clinically used to manage erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract symptoms of benign prostatic hyperplasia [/B][/I] [B][I]4. Experimental results and some clinical data suggest the potential for PDE5 inhibitors in the treatment of diseases that include cardiovascular disorders, Alzheimer’s disease, and cancer, among others[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When TRT Is Not Enough (ED, Libido, & More)
Beyond ED: cGMP-Specific PDE5i for Other Clinical Disorders
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