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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Beyond ED: cGMP-Specific PDE5i for Other Clinical Disorders
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<blockquote data-quote="madman" data-source="post: 242785" data-attributes="member: 13851"><p><strong>Figure 5 <u>PDE5 inhibitors and anticancer signaling</u>. The NO-cGMP signaling triggered by PDE5 inhibition inhibits β-catenin and increases the killing of multiple types of cancers. PDE5 inhibitors also enhance the effectiveness of multiple chemotherapeutics, including doxorubicin, by increasing their intracellular accumulation through inhibition of ABC transporter–mediated efflux. Abbreviations: ABCG1/2, ATP-binding cassette subfamily G 1/2; cGMP, cyclic guanosine monophosphate; MDSC, myeloid-derived suppressor cell; NO, nitric oxide; PDE5, phosphodiesterase 5; PDEi, PDE inhibitor; PKG, protein kinase G; pGC, particulate guanylate cyclase; sGC, soluble guanylate cyclase.</strong></p><p><strong>[ATTACH=full]28310[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 242785, member: 13851"] [B]Figure 5 [U]PDE5 inhibitors and anticancer signaling[/U]. The NO-cGMP signaling triggered by PDE5 inhibition inhibits β-catenin and increases the killing of multiple types of cancers. PDE5 inhibitors also enhance the effectiveness of multiple chemotherapeutics, including doxorubicin, by increasing their intracellular accumulation through inhibition of ABC transporter–mediated efflux. Abbreviations: ABCG1/2, ATP-binding cassette subfamily G 1/2; cGMP, cyclic guanosine monophosphate; MDSC, myeloid-derived suppressor cell; NO, nitric oxide; PDE5, phosphodiesterase 5; PDEi, PDE inhibitor; PKG, protein kinase G; pGC, particulate guanylate cyclase; sGC, soluble guanylate cyclase. [ATTACH type="full"]28310[/ATTACH][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Beyond ED: cGMP-Specific PDE5i for Other Clinical Disorders
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