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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Beyond ED: cGMP-Specific PDE5i for Other Clinical Disorders
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<blockquote data-quote="madman" data-source="post: 242781" data-attributes="member: 13851"><p><strong>Figure 2 <u>PDE5 as a therapeutic target for erectile dysfunction</u>. Sexual stimulation releases NO from noncholinergic, and nonadrenergic neurons in the penis and from endothelial cells. NO diffuses into cells and activates soluble GC, which converts GTP to cGMP. The cyclic nucleotide then stimulates PKG, which initiates a protein phosphorylation cascade, thereby decreasing intracellular levels of calcium ions, ultimately dilating the arteries that bring blood to the penis and compressing the spongy corpus cavernosum. PDE5 is the target for sildenafil and other PDE5 inhibitors for the treatment of erectile dysfunction. Abbreviations: cGMP, cyclic guanosine monophosphate; GTP, guanosine triphosphate, eNOS, endothelial nitric oxide synthase; nNOS, neuronal nitric oxide synthase; NO, nitric oxide; PDE5, phosphodiesterase 5; PKG, protein kinase G; sGC, soluble guanylyl cyclase.</strong></p><p><strong>[ATTACH=full]28305[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 242781, member: 13851"] [B]Figure 2 [U]PDE5 as a therapeutic target for erectile dysfunction[/U]. Sexual stimulation releases NO from noncholinergic, and nonadrenergic neurons in the penis and from endothelial cells. NO diffuses into cells and activates soluble GC, which converts GTP to cGMP. The cyclic nucleotide then stimulates PKG, which initiates a protein phosphorylation cascade, thereby decreasing intracellular levels of calcium ions, ultimately dilating the arteries that bring blood to the penis and compressing the spongy corpus cavernosum. PDE5 is the target for sildenafil and other PDE5 inhibitors for the treatment of erectile dysfunction. Abbreviations: cGMP, cyclic guanosine monophosphate; GTP, guanosine triphosphate, eNOS, endothelial nitric oxide synthase; nNOS, neuronal nitric oxide synthase; NO, nitric oxide; PDE5, phosphodiesterase 5; PKG, protein kinase G; sGC, soluble guanylyl cyclase. [ATTACH type="full"]28305[/ATTACH][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Beyond ED: cGMP-Specific PDE5i for Other Clinical Disorders
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