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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Beware of DHT
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<blockquote data-quote="madman" data-source="post: 196840" data-attributes="member: 13851"><p>What that study from 2003 done on rats!</p><p></p><p><em><strong>"</strong></em><strong><u><em>These observations suggest</em> that DHT</u> is responsible for the detrimental effects on cardiac</strong> <strong>function/morphology induced by testosterone</strong>. This is in agreement with our previous reports showing DHT as an inductor of myocardial damage (Regouat et al., 2018). In contrast, 4-OHA (Ki 3.28 μM) administration (Block et al., 1996) increased MMP-3 (P<0.05) and MMP-13 (P<0.01) expression. <strong>These results suggest that testosterone aromatization is associated with cardioprotection</strong>"</p><p></p><p></p><p></p><p></p><p>Notice in post #10 where I stated:</p><p></p><p>Sounds frantic to me and to go on claiming that.....<em><strong>Testosterones beneficial effects on the heart are caused by its conversion to Estrogen </strong></em><u><strong><em>while its deleterious effects are caused by its conversion to DHT</em></strong></u>.....is very misleading!</p><p></p><p>I specifically underlined while its deleterious effects are caused by its conversion to DHT.</p><p></p><p>As I and many very well know the important cardioprotective role estradiol plays when it comes to overall health.</p><p></p><p>If you take the time to search my numerous threads on the forum you will clearly see that I emphasize the importance of having healthy estradiol levels.</p><p></p><p></p><p></p><p></p><p>Take-home points I have stressed in numerous threads regarding e2!</p><p></p><p><strong>*Testosterone and more importantly its metabolites estradiol/DHT plays a huge role and are needed in healthy amounts to experiencing the full spectrum of beneficial effects.</strong></p><p><strong></strong></p><p><strong>*As you should very well know having healthy e2 levels are critical due to its beneficial effects on (cardiovascular health, brain health, libido, erectile function, bone health, tendon health, immune system, body composition).</strong></p></blockquote><p></p>
[QUOTE="madman, post: 196840, member: 13851"] What that study from 2003 done on rats! [I][B]"[/B][/I][B][U][I]These observations suggest[/I] that DHT[/U] is responsible for the detrimental effects on cardiac[/B] [B]function/morphology induced by testosterone[/B]. This is in agreement with our previous reports showing DHT as an inductor of myocardial damage (Regouat et al., 2018). In contrast, 4-OHA (Ki 3.28 μM) administration (Block et al., 1996) increased MMP-3 (P<0.05) and MMP-13 (P<0.01) expression. [B]These results suggest that testosterone aromatization is associated with cardioprotection[/B]" Notice in post #10 where I stated: Sounds frantic to me and to go on claiming that.....[I][B]Testosterones beneficial effects on the heart are caused by its conversion to Estrogen [/B][/I][U][B][I]while its deleterious effects are caused by its conversion to DHT[/I][/B][/U].....is very misleading! I specifically underlined while its deleterious effects are caused by its conversion to DHT. As I and many very well know the important cardioprotective role estradiol plays when it comes to overall health. If you take the time to search my numerous threads on the forum you will clearly see that I emphasize the importance of having healthy estradiol levels. Take-home points I have stressed in numerous threads regarding e2! [B]*Testosterone and more importantly its metabolites estradiol/DHT plays a huge role and are needed in healthy amounts to experiencing the full spectrum of beneficial effects. *As you should very well know having healthy e2 levels are critical due to its beneficial effects on (cardiovascular health, brain health, libido, erectile function, bone health, tendon health, immune system, body composition).[/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Beware of DHT
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