Beta-blocker responsible for significant ED, searching for BP meds that don’t cause ED.

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If it works like Losartan, the exssessive urination will lead to extreme dehydration and electrolyte imbalances.

How does Telmisartan compare side effects wise to Losartan?
i had some initial dizziness and headaches, but that passed quickly.
I had bad losartan s/x, probably dehydration as well (cramps). and awful anxiety
but none of that with telmisartan, might be worth a try
 
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I have been on Tamsulosin (0.4 mg) for little more than a week and very possibly results and no side effects. That’s not all, apparently my fasting glucose dropped dramatically. I read Tamsulosin works very well for type II hypertensive diabetics, metabolic syndrome as well as positive effects on lipids, glucose management and improving insulin sensitivity.

Alpha Blockers and Metabolic Syndrome

 
I would look into Bystolic (nebivolol). It is a 3rd generation beta blocker, is far superior to any of the previous generation BBs, is neutral or beneficial on lipids, glucose and insulin sensitivity, and is the only BB that produces endothelial nitric oxide.
I tried Nebivolol and it kept my heart rate low, I couldn't finish my workouts, like I was out of gas. It caused worsening ED and after stopping it, erections returned.

Bisoprolol allows my heart rate to climb higher.

Nebivolol also caused dehydration, which seems to be a common outcome of most blood pressure medicines for me.
 
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I have to take Metoprolol Succinate (beta -blocker). I was having bouts of tachycardia/a-fib, 3-4 times a year. I take 50mg in the AM and 75mg at PM mostly because my heart seemed to be racing between 2am and 4am. So far this has completely stopped the tachycardia/a-fib.

My sleeping heart rate is around 52, resting 63. When I go to the gym I am able to push my heart rate in the 140's - 150's with no problem. 137 bpm is 90% of my max HR so I have no problem training in the 90% + range, plus I usually train for just over 1 hour. No ED noticed.

I also take Telmisartan 80mg and hydrochlorothiazide 25mg. The only issue I have with the Metroprolol is standing up too quickly after being sitting for a while. I have to stand up and not move for a few seconds or I get damn dizzy.
 
I was a long time user of Metoprolol Succinate in the 100 to 150 mg range. Metoprolol is a cardioselective beta blocker, so it is definitely a positive for those concerned about more systemic effects (relaxing of the smooth muscle, causing breathing difficulties in those who have asthma or COPD, and ED). However, over time it does tend to have an adverse effect on energy metabolism, and I noticed my HbA1C creeping up without making any dietary changes, as well as fat accumulation. It took years. I switched to Nebivolol because it is the only cardioselective beta blocker that is a beta-3 agonist. In terms of ED, which was the OP's issue, Nebivolol theoretically has the benefit of boosting eNOS. I know there are lots of smart people here, and I'm just providing my experience.
 
I tried Nebivolol and it kept my heart rate low, I couldn't finish my workouts, like I was out of gas. It caused worsening ED and after stopping it, erections returned.

Bisoprolol allows my heart rate to climb higher.

Nebivolol also caused dehydration, which seems to be a common outcome of most blood pressure medicines for me.
i tried bystolic as well. hell on earth. depressed, can't workout. cant lift can't bike. i decided i stick to telmi and try to bring it down naturally, and temporary run higher. there is no good addition to ARB's. maybe amlodipine
 
I take Losartan, it doesn’t make me piss all day, I don’t think they mix it with a diuretic like Telmisartan. If they do, I’m not on that version.
 
I have to take Metoprolol Succinate (beta -blocker). I was having bouts of tachycardia/a-fib, 3-4 times a year. I take 50mg in the AM and 75mg at PM mostly because my heart seemed to be racing between 2am and 4am. So far this has completely stopped the tachycardia/a-fib.

My sleeping heart rate is around 52, resting 63. When I go to the gym I am able to push my heart rate in the 140's - 150's with no problem. 137 bpm is 90% of my max HR so I have no problem training in the 90% + range, plus I usually train for just over 1 hour. No ED noticed.

I also take Telmisartan 80mg and hydrochlorothiazide 25mg. The only issue I have with the Metroprolol is standing up too quickly after being sitting for a while. I have to stand up and not move for a few seconds or I get damn dizzy.
waking up with a fast heart rate is sometimes a sign of High Cortisol. Maybe you are overtraining
 
waking up with a fast heart rate is sometimes a sign of High Cortisol. Maybe you are overtraining
Yet my cortisol is average and at 68 years old and osteoarthritis in most of my joints, I am lucky to just go to the gym at all. My cardiologist knew the answer to this one, and it he said it was a normal response in the circadian cycle. From 3-4am there is a sharp increase in blood pressure and the heart rate starts to rise. The morning is also when most people have heart attacks. One theory looks at a protein in your blood called plasminogen activator inhibitor 1(PA1), which prevents clots from dissolving. There is also a sharp increase in PA1 levels. My resting HR is normally 63bpm and it drops to 52bpm during the night.
 
I was forced to stop Cialis which was treating the side effects of my beta blocker. Now it’s shutting me down hard.

The muscle weakness, lightheadedness and fatigue is draining me. The Cialis caused hot flashes, some fatigue and stopped working on the ED front.

Cialis also indirectly caused a vitamin D deficiency that no amount of supplements would get my vitamin D to budge.

What’s always been weird is when coming from a deficiency in vitamin D, the first 5 days of supplementation always brought about no issues at all with strength, energy and errections, but after that these symptoms appear.

The symptoms seem to start when my urination slows down and it’s difficult to pee. When the urine does come out of my penis, it sprays and all directions. When I urinate more a little more, these symptoms go away.

I somehow managed to get an erection I and try to ejaculate, it gets trapped in the center of my penis, making my penis bulge in the center and won’t come out and I get cramping for 20 hours.

I did confirm estrogen at 18 pg/mL (TT 592 ng/dL) and was likely lower as I was tapering off when I checked it.

I need another blood pressure medicine!
 
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I found Zilebesiran which is an injectable blood pressure medicine that last for 6 months and in the clinical trial, it improved erectile function significantly and orgasm quality in 78% of participants.

Has anyone ever heard of Zilebesiran?
 
The conclusion seems axiomatic. In patients diagnosed with heart failure with preserved ejection fraction (a distinct subset of heart failure patients), withdrawing beta blockers resulted in short term increased exercise tolerance. I can't see the underlying study design to discern what "generation" of beta blockers was used. Admittedly, they all reduce heart rate to a degree, but one of the supposed benefits of Bystolic (Nebivolol) is that it does not impact exercise tolerance as much as the older classes of BB.
 
My psychiatrist prescribed propranolol for anxiety, as well to attenuate the various stress reactions I'm experiencing from being my wife's caregiver. It's widely used off label in that manner. Yes, it helps with the ongoing stress, it lowers BP, but if I take it at night, it worsens my already mediocre/poor sleep. On Reddit, on the r/cptsd sub, many who post state that propanolol alone, or along with some other psych drug, has allowed people to function.

My primary is smart but it's my psychiatrist who's keeping me from sinking. I long ago abandoned the pursuit of 'perfect' in regards to medications. For sleep and C-PTSD, been through prazosin, doxazosin, clonidine, guanfacine over the past few years. Seems that I'm stuck with clonazepam. Though it and propranolol can or do impact sexual function, most nights, between 9 and 10, I still get my daily erection thanks to testosterone.
 
My psychiatrist prescribed propranolol for anxiety, as well to attenuate the various stress reactions I'm experiencing from being my wife's caregiver. It's widely used off label in that manner. Yes, it helps with the ongoing stress, it lowers BP, but if I take it at night, it worsens my already mediocre/poor sleep. On Reddit, on the r/cptsd sub, many who post state that propanolol alone, or along with some other psych drug, has allowed people to function.

My primary is smart but it's my psychiatrist who's keeping me from sinking. I long ago abandoned the pursuit of 'perfect' in regards to medications. For sleep and C-PTSD, been through prazosin, doxazosin, clonidine, guanfacine over the past few years. Seems that I'm stuck with clonazepam. Though it and propranolol can or do impact sexual function, most nights, between 9 and 10, I still get my daily erection thanks to testosterone.
That makes sense because propranolol and metaprolol are known for impairing melatonin production.
 
That makes sense because propranolol and metaprolol are known for impairing melatonin production.
I have read that. Topic digression. Experimented with melatonin on and off for years and it didn't help. Recently, after listening to top melatonin researchers on YouTube and talking with someone who takes daily high doses, I tried 100 mg in late afternoon, since I usually go to sleep around 10. Went to sleep at 9, woke up at 3 a.m., had a melatonin hangover most of the day, was agitated, as well as depressed. I had to know if there was something positive about higher dosing. It's now off my list. Magnesium(carbonate, malate, glycinate) worsens my sleep, even if I take it in the morning. Same for taurine, same for vitamin D.

I once saw on a peptide site, Delta Slow Wave Inducing Peptide. Tempting, but never having experimented with peptides, I've been reluctant to try it. Back to experimenting with DHEA. For 20 years, early morning awakening(4 to 4:30) and depression. Everything I've read indicates a malfunction of the HPA axis associated with mental illness(I have treatment resistant bipolar).
 
I found Zilebesiran which is an injectable blood pressure medicine that last for 6 months and in the clinical trial, it improved erectile function significantly and orgasm quality in 78% of participants.

Has anyone ever heard of Zilebesiran?
I would be cautious with an injectable with that half-life. I just tried one Repatha injectable and 6 weeks later dealing with all sorts of bad sides. going to let my cholesterol run...sorry did not mean to hijack the thread but I am now real cautious with long half-life anything.
 
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