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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Benefits of Daily Cialis?
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<blockquote data-quote="Nelson Vergel" data-source="post: 129950" data-attributes="member: 3"><p><span style="font-size: 26px"><strong>DAILY 5 MG TADALAFIL IN MEN WITH ERECTILE DYSFUNCTION AND DIABETES: A PROSPECTIVE, OBSERVATIONAL 2-YEAR STUDY</strong></span></p><p></p><p></p><p>The Journal of Urology</p><p>Volume 195, Issue 4, Supplement, April 2016, Pages e1189-e1190</p><p></p><p>Men with ED and diabetes who were naïve to PDE5 inhibitors were assigned to 20 mg tadalafil on-demand or 5 mg tadalafil once daily and asked to provide information about erectile function at the start of treatment and after 2 years. When men completed the questionnaire after 2 years of treatment, they also stopped the medication for 4 weeks to check their baseline erectile function. The primary efficacy variable was the IIEF-EF score. Secondary efficacy variables included a change in the scores IIEF Q3 and Q4 from baseline, changes in all domain scores on the IIEF from baseline, SEP2 and SEP3, and the GAQ. Rigiscan® measurements of nocturnal penile tumescence and rigidity (NPTR) were also carried out 2 years after treatment.</p><p></p><p>RESULTS</p><p>The study enrolled 118 men (mean age: 56.2yrs) and most had mild to moderate ED (57.6%): 65 patients (55.1%) were prescribed 20 mg tadalafil on demand and 53 patients (44.9%) took 5 mg tadalafil once daily. Men who switched treatment patterns were excluded. The mean number of doses in the on-demand group was 2.9/month. After 2 years of treatment, the daily treatment group had a significantly greater change in the IIEF-EF domain score from baseline compared with the on-demand group (7.3 vs. 2.4, P < 0.0001). The changes in IIEF from baseline on Q3 (1.4 vs. 0.4, P < 0.0001) and Q4 (1.4 vs. 0.3, P < 0.0001) were higher in the daily group than in the on-demand group. Differences between the daily and on-demand groups were significant for SEP2 (53.8% vs. 32.3%, P = 0.0003) and SEP3 (56.6% vs. 15.4%, P < 0.0001). The difference in GAQ “YES” responses was also significant (66.0% vs. 27.7%, P < 0.0001). Normal EF domain scores (≥26) at the end of the study were achieved by 20.7% and 6.2% in the daily and on-demand groups, respectively (P = 0.0031). Normal patterns of NPTR at the end of the study were achieved by 13.2% only in the daily group. Most treatment-associated adverse events were mild and resolved spontaneously.</p><p></p><p>CONCLUSIONS</p><p>Long-term use of 5 mg tadalafil once daily was more beneficial for improving baseline erectile function or preventing ED than the on-demand pattern in men with ED and diabetes.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 129950, member: 3"] [SIZE=26px][B]DAILY 5 MG TADALAFIL IN MEN WITH ERECTILE DYSFUNCTION AND DIABETES: A PROSPECTIVE, OBSERVATIONAL 2-YEAR STUDY[/B][/SIZE] The Journal of Urology Volume 195, Issue 4, Supplement, April 2016, Pages e1189-e1190 Men with ED and diabetes who were naïve to PDE5 inhibitors were assigned to 20 mg tadalafil on-demand or 5 mg tadalafil once daily and asked to provide information about erectile function at the start of treatment and after 2 years. When men completed the questionnaire after 2 years of treatment, they also stopped the medication for 4 weeks to check their baseline erectile function. The primary efficacy variable was the IIEF-EF score. Secondary efficacy variables included a change in the scores IIEF Q3 and Q4 from baseline, changes in all domain scores on the IIEF from baseline, SEP2 and SEP3, and the GAQ. Rigiscan® measurements of nocturnal penile tumescence and rigidity (NPTR) were also carried out 2 years after treatment. RESULTS The study enrolled 118 men (mean age: 56.2yrs) and most had mild to moderate ED (57.6%): 65 patients (55.1%) were prescribed 20 mg tadalafil on demand and 53 patients (44.9%) took 5 mg tadalafil once daily. Men who switched treatment patterns were excluded. The mean number of doses in the on-demand group was 2.9/month. After 2 years of treatment, the daily treatment group had a significantly greater change in the IIEF-EF domain score from baseline compared with the on-demand group (7.3 vs. 2.4, P < 0.0001). The changes in IIEF from baseline on Q3 (1.4 vs. 0.4, P < 0.0001) and Q4 (1.4 vs. 0.3, P < 0.0001) were higher in the daily group than in the on-demand group. Differences between the daily and on-demand groups were significant for SEP2 (53.8% vs. 32.3%, P = 0.0003) and SEP3 (56.6% vs. 15.4%, P < 0.0001). The difference in GAQ “YES” responses was also significant (66.0% vs. 27.7%, P < 0.0001). Normal EF domain scores (≥26) at the end of the study were achieved by 20.7% and 6.2% in the daily and on-demand groups, respectively (P = 0.0031). Normal patterns of NPTR at the end of the study were achieved by 13.2% only in the daily group. Most treatment-associated adverse events were mild and resolved spontaneously. CONCLUSIONS Long-term use of 5 mg tadalafil once daily was more beneficial for improving baseline erectile function or preventing ED than the on-demand pattern in men with ED and diabetes. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Benefits of Daily Cialis?
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