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Bad News For Egg Lovers
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<blockquote data-quote="dnfuss" data-source="post: 142259" data-attributes="member: 15487"><p>Only if the cited study the conclusion is based on is a rigorous and properly designed clinical trial with robust statistical significance. This study is nothing of the kind. Not even close.</p><p></p><p></p><p></p><p>You're correct, although actually closer to 20x. Studies with hazard ratios this low are simply not even indicative of any likely association, much less causation (remember, this is an observational study, so it can't actually show causation, just association at best).</p><p></p><p></p><p></p><p>Absolutely right. Food questionnaires, especially those compiled from recollection (as opposed to a daily diary filled out with each meal) are quite useless. Further confounding is the compliance effect. Those who seek to maintain what they are told are healthy habits (as when they are told that eating lots of eggs is unhealthy, still the advice most commonly heard) generally try to maintain other healthy behaviors. Data from a large statin trial when examined for compliance to the regimen revealed that five-year mortality in compliant placebo recipients was lower than in non-compliant recipients of the drug. I.e., the mere fact of being health-conscious (compliant with the (perceived) medication regimen) had a stronger effect on mortality in some sense than the drug itself!</p><p></p><p>The value of almost all observational studies is basically nil, except as a starting point for formulating a hypothesis that can be tested in a RCT (even better if it's double-blind and placebo-controlled, if that's possible). And the HR should be well above two (preferably closer to five) to justify the RCT.</p></blockquote><p></p>
[QUOTE="dnfuss, post: 142259, member: 15487"] Only if the cited study the conclusion is based on is a rigorous and properly designed clinical trial with robust statistical significance. This study is nothing of the kind. Not even close. You're correct, although actually closer to 20x. Studies with hazard ratios this low are simply not even indicative of any likely association, much less causation (remember, this is an observational study, so it can't actually show causation, just association at best). Absolutely right. Food questionnaires, especially those compiled from recollection (as opposed to a daily diary filled out with each meal) are quite useless. Further confounding is the compliance effect. Those who seek to maintain what they are told are healthy habits (as when they are told that eating lots of eggs is unhealthy, still the advice most commonly heard) generally try to maintain other healthy behaviors. Data from a large statin trial when examined for compliance to the regimen revealed that five-year mortality in compliant placebo recipients was lower than in non-compliant recipients of the drug. I.e., the mere fact of being health-conscious (compliant with the (perceived) medication regimen) had a stronger effect on mortality in some sense than the drug itself! The value of almost all observational studies is basically nil, except as a starting point for formulating a hypothesis that can be tested in a RCT (even better if it's double-blind and placebo-controlled, if that's possible). And the HR should be well above two (preferably closer to five) to justify the RCT. [/QUOTE]
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Bad News For Egg Lovers
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