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Mental Health
Association of Testosterone Treatment With Alleviation of Depressive Symptoms in Men
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<blockquote data-quote="madman" data-source="post: 160230" data-attributes="member: 13851"><p><strong><span style="color: rgb(184, 49, 47)">To our knowledge, the present meta-analysis is </span></strong><span style="color: rgb(44, 130, 201)"><strong>the largest examination to date of the association of testosterone treatment with depressive symptoms in men, including 27 RCTs comprising 1890 men. </strong></span><strong><span style="color: rgb(184, 49, 47)">Replicating and extending previous work, </span><span style="color: rgb(44, 130, 201)">we show evidence for a moderate antidepressant association of testosterone treatment compared with placebo, identifying an effect size of the overall analysis of Hedges gof 0.21. </span></strong><span style="color: rgb(26, 188, 156)"><strong>Based on reference ranges for depressive symptoms, this effect is translatable into a clinically relevant symptom reduction by 2.2 points on the BDI-II. </strong></span><strong><span style="color: rgb(147, 101, 184)"><strong>The National Institute for Health and Care Excellence guidelines on depression suggest a reduction of 3.0 and 2.0 points on BDI scores to be clinically significant for normal depression and treatment-resistant depression, respectively. </strong></span><span style="color: rgb(26, 188, 156)">Furthermore, testosterone treatment revealed an efficacy OR of 2.30, suggesting the potential of testosterone treatment as adjunct therapy for men with depressive disorders. </span><span style="color: rgb(184, 49, 47)">Acceptability of testosterone treatment was high, showing an OR of 0.79 for testosterone treatment– related loss to follow-up when compared with placebo. </span><span style="color: rgb(26, 188, 156)">This outcome suggests that testosterone treatment is rather positively experienced and potential adverse effects seem rare. </span></strong>Endocrine Society clinical practice guidelines also conclude that there are insufficient data to establish a causal link between testosterone treatment and clinical conditions, such as cardiovascular events or prostate cancer. Still, the guidelines do not recommend testosterone treatment in testosterone-deficient men with increased risk for these conditions because much larger postmarketing surveillance studies would be necessary to assess whether testosterone treatment is associated with increased risk of rare adverse drug reactions.</p></blockquote><p></p>
[QUOTE="madman, post: 160230, member: 13851"] [B][COLOR=rgb(184, 49, 47)]To our knowledge, the present meta-analysis is [/COLOR][/B][COLOR=rgb(44, 130, 201)][B]the largest examination to date of the association of testosterone treatment with depressive symptoms in men, including 27 RCTs comprising 1890 men. [/B][/COLOR][B][COLOR=rgb(184, 49, 47)]Replicating and extending previous work, [/COLOR][COLOR=rgb(44, 130, 201)]we show evidence for a moderate antidepressant association of testosterone treatment compared with placebo, identifying an effect size of the overall analysis of Hedges gof 0.21. [/COLOR][/B][COLOR=rgb(26, 188, 156)][B]Based on reference ranges for depressive symptoms, this effect is translatable into a clinically relevant symptom reduction by 2.2 points on the BDI-II. [/B][/COLOR][B][COLOR=rgb(147, 101, 184)][B]The National Institute for Health and Care Excellence guidelines on depression suggest a reduction of 3.0 and 2.0 points on BDI scores to be clinically significant for normal depression and treatment-resistant depression, respectively. [/B][/COLOR][COLOR=rgb(26, 188, 156)]Furthermore, testosterone treatment revealed an efficacy OR of 2.30, suggesting the potential of testosterone treatment as adjunct therapy for men with depressive disorders. [/COLOR][COLOR=rgb(184, 49, 47)]Acceptability of testosterone treatment was high, showing an OR of 0.79 for testosterone treatment– related loss to follow-up when compared with placebo. [/COLOR][COLOR=rgb(26, 188, 156)]This outcome suggests that testosterone treatment is rather positively experienced and potential adverse effects seem rare. [/COLOR][/B]Endocrine Society clinical practice guidelines also conclude that there are insufficient data to establish a causal link between testosterone treatment and clinical conditions, such as cardiovascular events or prostate cancer. Still, the guidelines do not recommend testosterone treatment in testosterone-deficient men with increased risk for these conditions because much larger postmarketing surveillance studies would be necessary to assess whether testosterone treatment is associated with increased risk of rare adverse drug reactions. [/QUOTE]
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Mental Health
Association of Testosterone Treatment With Alleviation of Depressive Symptoms in Men
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