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Ask The Urologist Anything (Dr Michael Rotman)
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<blockquote data-quote="MikeXL" data-source="post: 64501" data-attributes="member: 4958"><p>Dr Rotman</p><p>Thanks for you time on this board. Maybe you did not see my original question</p><p></p><p>Maybe it is something that you can research as well. </p><p></p><p> What is the hormonal ramifications of lowering SHBG besides increasing free T. If I understand correctly, SHBG also binds E2 and DHT. if that is the case, lowering SHBG would also increase free E2 and Free DHT. I have heard that SHBG has the greatest affinity to DHT then T and then E2. If that is the case, would lowering SHBG have a greater affect on freeing up E2, then T, then DHT? Or do I have that backwards? Or would it matter ?</p></blockquote><p></p>
[QUOTE="MikeXL, post: 64501, member: 4958"] Dr Rotman Thanks for you time on this board. Maybe you did not see my original question Maybe it is something that you can research as well. What is the hormonal ramifications of lowering SHBG besides increasing free T. If I understand correctly, SHBG also binds E2 and DHT. if that is the case, lowering SHBG would also increase free E2 and Free DHT. I have heard that SHBG has the greatest affinity to DHT then T and then E2. If that is the case, would lowering SHBG have a greater affect on freeing up E2, then T, then DHT? Or do I have that backwards? Or would it matter ? [/QUOTE]
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