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<blockquote data-quote="dnfuss" data-source="post: 93255" data-attributes="member: 15487"><p>Re: Aspirin and HCG</p><p></p><p>Dr. McClain,</p><p></p><p>I have read with concern recent studies supporting the antiandrogenic properties of NSAIDs. See, e.g., "<a href="http://www.pnas.org/content/early/2018/01/03/1715035115.full.pdf" target="_blank">Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism</a>." I noted with particular interest the further study cited in footnote 34 thereto ("<a href="http://www.physiology.org/doi/pdf/10.1152/ajpendo.1999.277.6.E1032" target="_blank">Aspirin inhibits androgen response to chorionic gonadotropin in humans</a>").</p><p></p><p>My current TRT protocol includes 500 IU HCG, administered SubQ q.3.5d., and among other things I am also currently on aspirin, 81 mg q.d. It was not prescribed by my doctor, but I thought it might be cheap insurance given my age and some of my lipid levels.</p><p></p><p>The latter study above made me wonder if perhaps I should stop aspirin? Or should I not be concerned because the dose I'm on is only approximately 10% of the dose used in the study (800 mg. b.i.d.)?</p></blockquote><p></p>
[QUOTE="dnfuss, post: 93255, member: 15487"] Re: Aspirin and HCG Dr. McClain, I have read with concern recent studies supporting the antiandrogenic properties of NSAIDs. See, e.g., "[URL="http://www.pnas.org/content/early/2018/01/03/1715035115.full.pdf"]Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism[/URL]." I noted with particular interest the further study cited in footnote 34 thereto ("[URL="http://www.physiology.org/doi/pdf/10.1152/ajpendo.1999.277.6.E1032"]Aspirin inhibits androgen response to chorionic gonadotropin in humans[/URL]"). My current TRT protocol includes 500 IU HCG, administered SubQ q.3.5d., and among other things I am also currently on aspirin, 81 mg q.d. It was not prescribed by my doctor, but I thought it might be cheap insurance given my age and some of my lipid levels. The latter study above made me wonder if perhaps I should stop aspirin? Or should I not be concerned because the dose I'm on is only approximately 10% of the dose used in the study (800 mg. b.i.d.)? [/QUOTE]
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