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<blockquote data-quote="MikeXL" data-source="post: 92268" data-attributes="member: 4958"><p>Dr. McClain</p><p>I realize that finasteride and dutasteride both block conversion of progesterone to 5-DHP, 5-isoprogesterone and 5-alloprogesterone, which are important neurohoromones. Can this effect of finasteride and dutasteride be offset or partially offset by taking pregnolone or progesterone in an effort to increase the available substrate to create 5-DHP, 5-isoP and 5-alloP?</p><p></p><p></p><p>Here are the approximate labs of a buddy of mine</p><p>Prior to TRT - T = 300; DHT = 20</p><p>TRT only - T = 1,300; DHT = 85</p><p>TRT and finasteride - T = 1,300; DHT = 30</p><p></p><p>He did not use finasteride prior to TRT, but if he had, I am sure his DHT would have been single digits. As you can see, his DHT on TRT with finasteride is higher than his DHT was when he had low T. So it seems that the DHT lowering effect of finasteride was more than offset by increasing the DHT substrate (Testosterone)</p><p></p><p>So, I am wondering if the progesterone-metabolite-lowering effect of finasteride could be offset by increasing the substrate of these metabolite, which in this case would be progesterone/pregnenolone</p></blockquote><p></p>
[QUOTE="MikeXL, post: 92268, member: 4958"] Dr. McClain I realize that finasteride and dutasteride both block conversion of progesterone to 5-DHP, 5-isoprogesterone and 5-alloprogesterone, which are important neurohoromones. Can this effect of finasteride and dutasteride be offset or partially offset by taking pregnolone or progesterone in an effort to increase the available substrate to create 5-DHP, 5-isoP and 5-alloP? Here are the approximate labs of a buddy of mine Prior to TRT - T = 300; DHT = 20 TRT only - T = 1,300; DHT = 85 TRT and finasteride - T = 1,300; DHT = 30 He did not use finasteride prior to TRT, but if he had, I am sure his DHT would have been single digits. As you can see, his DHT on TRT with finasteride is higher than his DHT was when he had low T. So it seems that the DHT lowering effect of finasteride was more than offset by increasing the DHT substrate (Testosterone) So, I am wondering if the progesterone-metabolite-lowering effect of finasteride could be offset by increasing the substrate of these metabolite, which in this case would be progesterone/pregnenolone [/QUOTE]
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