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<blockquote data-quote="Rand McClain DO" data-source="post: 91042" data-attributes="member: 90"><p>Hi Orrin,</p><p>Clomid and HCG work by very different MOA's. Clomid is a selective estrogen receptor blocker (so, eg, it blocks estrogen reception at the pituitary, but not at the liver) while HCG mimics the effect of LH on the Leydig Cells (testosterone producing) of the testes. The net result one is typically trying to achieve is to get the testicles producing more testosterone (and in cases of infertility, thereby get the local production of testosterone in sufficient amount to catalyze the production of sperm by the adjacent Sartoli cells). </p><p>Whether one has high T or high E, the pituitary will not produce LH to stimulate the Leydig Cells to make more T (part of what is referred to as "negative feedback"). What if I have low T and high E? Why wouldn't my body what to produce more T? Because, estrogen is made from testosterone, so, again, if (either T or) estrogen is high, then even if T is low, again because E is made from T, then the pituitary will not send a signal (LH) to produce more T. I know, a gyp, but it is the way it works - don't shoot the messenger. </p><p>So, with Clomid, by blocking the pituitary's reception of E, when T is low, it satisfies the conditions under which the pituitary can send a signal to make more T. With HCG, we are imply overriding the system and telling the testicles directly to make more T. So, you can see that both HCG and Clomid could be used together to effectuate a rise in T.</p><p>Not sure that a weekly dose (as well as such a small one - Clomid dose it typically 50mg either every day or every other day) of Clomid would be effective at stimulating T production.</p></blockquote><p></p>
[QUOTE="Rand McClain DO, post: 91042, member: 90"] Hi Orrin, Clomid and HCG work by very different MOA's. Clomid is a selective estrogen receptor blocker (so, eg, it blocks estrogen reception at the pituitary, but not at the liver) while HCG mimics the effect of LH on the Leydig Cells (testosterone producing) of the testes. The net result one is typically trying to achieve is to get the testicles producing more testosterone (and in cases of infertility, thereby get the local production of testosterone in sufficient amount to catalyze the production of sperm by the adjacent Sartoli cells). Whether one has high T or high E, the pituitary will not produce LH to stimulate the Leydig Cells to make more T (part of what is referred to as "negative feedback"). What if I have low T and high E? Why wouldn't my body what to produce more T? Because, estrogen is made from testosterone, so, again, if (either T or) estrogen is high, then even if T is low, again because E is made from T, then the pituitary will not send a signal (LH) to produce more T. I know, a gyp, but it is the way it works - don't shoot the messenger. So, with Clomid, by blocking the pituitary's reception of E, when T is low, it satisfies the conditions under which the pituitary can send a signal to make more T. With HCG, we are imply overriding the system and telling the testicles directly to make more T. So, you can see that both HCG and Clomid could be used together to effectuate a rise in T. Not sure that a weekly dose (as well as such a small one - Clomid dose it typically 50mg either every day or every other day) of Clomid would be effective at stimulating T production. [/QUOTE]
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