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<blockquote data-quote="Rand McClain DO" data-source="post: 91031" data-attributes="member: 90"><p>Hi Vince,</p><p>With regard to chasing the elusive magic estradiol (E2) NUMBER, it can be difficult to hit because typically as one reduces E2, the SHBG is reduced which of course frees up more E2, which lowers SHBG, etc. This explains why many see a drop from say 55pg/ml to 28pg/ml of E2 with just one dose of strategically placed anastrozole 1mg, and yet require anastrozole 1mg every other day to get E2 to 15-20pg/ml. As for the determining the magic E2 state that works for each individual, I find that (generally) men tend to do well with E2 (sensitive assay is what I find adequate) between 15-20pg/ml, but exceptions exist such as with strength athletes. Some "Strongmen" competitors I know complain of tendon/joint pain and strength reduction when E2 is maintained that low and prefer levels closer to 30-35pg/ml. Also, men who are sensitive to E2 tend to do better with slightly higher levels (but I have seen the reverse as well). Eg, if E2 drops below 15mg/ml, these men tend to complain of lack of genital sensitivity which can lead to ED and lack of libido. In such case, we agree to shoot for a slightly higher E2 range to protect against its ever dipping too low. </p><p>As for your specific question of measuring FREE E2, I have no experience using this assay. Your assertion that it may be a better assay to use is a good one though since it gives us even more detailed information. I will consider using it if I run across a particularly difficult E2 titration case and report back.</p></blockquote><p></p>
[QUOTE="Rand McClain DO, post: 91031, member: 90"] Hi Vince, With regard to chasing the elusive magic estradiol (E2) NUMBER, it can be difficult to hit because typically as one reduces E2, the SHBG is reduced which of course frees up more E2, which lowers SHBG, etc. This explains why many see a drop from say 55pg/ml to 28pg/ml of E2 with just one dose of strategically placed anastrozole 1mg, and yet require anastrozole 1mg every other day to get E2 to 15-20pg/ml. As for the determining the magic E2 state that works for each individual, I find that (generally) men tend to do well with E2 (sensitive assay is what I find adequate) between 15-20pg/ml, but exceptions exist such as with strength athletes. Some "Strongmen" competitors I know complain of tendon/joint pain and strength reduction when E2 is maintained that low and prefer levels closer to 30-35pg/ml. Also, men who are sensitive to E2 tend to do better with slightly higher levels (but I have seen the reverse as well). Eg, if E2 drops below 15mg/ml, these men tend to complain of lack of genital sensitivity which can lead to ED and lack of libido. In such case, we agree to shoot for a slightly higher E2 range to protect against its ever dipping too low. As for your specific question of measuring FREE E2, I have no experience using this assay. Your assertion that it may be a better assay to use is a good one though since it gives us even more detailed information. I will consider using it if I run across a particularly difficult E2 titration case and report back. [/QUOTE]
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