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Hi Dr McClain,

I have been suffering from "Post Finasteride Syndrome" for over 10 years. The majority of doctors around the world believe that this condition is extremely complex and there is no known cure.

What is your take on Post Finasteride Syndrome? Is it curable?

My situation is that I took Finasteride for around 6 months and at some point (I think when I discontinued it) my free testosterone fell to below range as well as my LH with FSH being very low. Would you suspect ongoing estrogen dominance here?

I have tried TRT, PCT and low dose Arimidex which have not made me any better. Free T and LH remain low over 10 years later.

I do not have sensitive E2 testing in my country and so my E2 has often come back mid range.

Also how do you work around E2 testing if sensitive testing is not available?

Appreciate your response.

<blockquote data-quote="Mark_Smith" data-source="post: 126407" data-attributes="member: 31192">Hi Dr McClain,I have been suffering from &quot;Post Finasteride Syndrome&quot; for over 10 years. The majority of doctors around the world believe that this condition is extremely complex and there is no known cure.What is your take on Post Finasteride Syndrome? Is it curable?My situation is that I took Finasteride for around 6 months and at some point (I think when I discontinued it) my free testosterone fell to below range as well as my LH with FSH being very low. Would you suspect ongoing estrogen dominance here?I have tried TRT, PCT and low dose Arimidex which have not made me any better. Free T and LH remain low over 10 years later.I do not have sensitive E2 testing in my country and so my E2 has often come back mid range.Also how do you work around E2 testing if sensitive testing is not available?Appreciate your response.</blockquote>

[QUOTE="Mark_Smith, post: 126407, member: 31192"] Hi Dr McClain, I have been suffering from "Post Finasteride Syndrome" for over 10 years. The majority of doctors around the world believe that this condition is extremely complex and there is no known cure. What is your take on Post Finasteride Syndrome? Is it curable? My situation is that I took Finasteride for around 6 months and at some point (I think when I discontinued it) my free testosterone fell to below range as well as my LH with FSH being very low. Would you suspect ongoing estrogen dominance here? I have tried TRT, PCT and low dose Arimidex which have not made me any better. Free T and LH remain low over 10 years later. I do not have sensitive E2 testing in my country and so my E2 has often come back mid range. Also how do you work around E2 testing if sensitive testing is not available? Appreciate your response. [/QUOTE]

Verification

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038